Method of obtaining one-dimensional high resolution nuclear magnetic resonance spectrum under nonuniform magnetic field

A technology of nuclear magnetic resonance spectroscopy and uniform magnetic field, which is used in the measurement of magnetic variables, measurement devices, instruments, etc., and can solve the problems of low signal-to-noise ratio and inability to directly obtain high-resolution chemical shift information.

Inactive Publication Date: 2014-04-23
XIAMEN UNIV
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Problems solved by technology

The above methods either cannot directly obtain high-resolution chemical shift information, or require pri

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  • Method of obtaining one-dimensional high resolution nuclear magnetic resonance spectrum under nonuniform magnetic field
  • Method of obtaining one-dimensional high resolution nuclear magnetic resonance spectrum under nonuniform magnetic field
  • Method of obtaining one-dimensional high resolution nuclear magnetic resonance spectrum under nonuniform magnetic field

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Embodiment Construction

[0036] Below in conjunction with accompanying drawing and embodiment, the present invention will be further described:

[0037] In this embodiment, a Varian 500 MHz magnetic resonance instrument equipped with a three-dimensional gradient field is used, and the sample is ethyl tribromopropionate solution. The pulse sequence used is as figure 1 shown.

[0038] refer to figure 2 , the unevenness of the magnetic field is only serious in one direction, and it is realized by adjusting the shim coil in the Z direction. The sampling gradient of the echo plane spectrum imaging module is only applied in the Z direction, and no phase encoding gradient is applied. The magnitude of the sampling gradient Ga is 29.3 gauss / cm, the duration Ta of a single gradient is 200 microseconds, and the number Na of gradient pairs is 800. The total time required to sample the signal is less than 1 second. The sampled data are rearranged and subjected to two-dimensional Fourier transform.

[0039] In...

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Abstract

The invention provides a method of obtaining a high resolution nuclear magnetic resonance spectrum under a nonuniform magnetic field. The method comprises the steps of firstly applying a radio frequency pulse, rotating a magnetization vector from a Z axis to an XY plane, applying phase coding gradients along two directions, applying a sampling gradient of an echo plane spectrum imaging module on a third direction, collecting nuclear magnetic resonance signals, performing data permutation on the collected signals, and performing Fourier transform on a data matrix obtained by the permutation so as to obtain the nuclear magnetic resonance spectrums corresponding to a series of small voxels. The nuclear magnetic resonance spectrum corresponding to each small voxel is in high resolution; as the nonuniform magnetic field exists, the small voxels are directly projected in an accumulative mode, the obtain spectrums are in low resolution; the offset correction is performed on the spectrums corresponding to the small voxels, accumulative projection is then performed, the high resolution one-dimensional nuclear magnetic resonance spectrum can be obtained, and the obtained high resolution spectrum facilitates chemical analysis in a heterogeneous system.

Description

technical field [0001] The invention relates to a method for obtaining a high-resolution nuclear magnetic resonance spectrum, in particular to a method capable of obtaining a high-resolution nuclear magnetic resonance spectrum under an inhomogeneous magnetic field. Background technique [0002] High-resolution NMR spectra can provide information such as chemical shift, scalar coupling, spectral peak splitting mode, and relative spectral peak area ratio, thereby providing information on molecular structure and dynamics. It is widely used in physics, chemistry, biology, medicine and It has been widely used in materials science and other fields. For traditional high-resolution liquid NMR, the uniformity of the magnetic field generally exceeds 10 -8 . However, in many cases, the uniformity of the magnetic field will decrease, which cannot meet the requirements of sampling high-resolution NMR spectra. These situations include single-sided magnet NMR (Blümich B, Perlo J, Casano...

Claims

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Application Information

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IPC IPC(8): G01R33/565
Inventor 林雁勤韦芝良陈忠林良杰
Owner XIAMEN UNIV
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