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Application of a compound in medicine for treating renal insufficiency

A compound and kidney function technology, applied in the application field of MollolideA in the preparation of drugs for the treatment of renal insufficiency, can solve the problems of high toxicity and side effects, high price, dependence on imports, etc., and achieve the effect of strong therapeutic activity and outstanding substantive characteristics

Inactive Publication Date: 2015-11-25
徐海军 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Benazepril and Losartan are currently clinically used to treat renal insufficiency, but they mainly rely on imports. These drugs are expensive and have relatively high toxicity and side effects.

Method used

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  • Application of a compound in medicine for treating renal insufficiency
  • Application of a compound in medicine for treating renal insufficiency
  • Application of a compound in medicine for treating renal insufficiency

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of the compound MollolideA tablet involved in the present invention:

[0017] Take 5 grams of compound Mollolide A and add 195 grams of dextrin, mix well, and make 1000 tablets by conventional tableting.

Embodiment 2

[0018] Embodiment 2: the preparation of compound MollolideA capsules involved in the present invention:

[0019] Get 5 grams of compound Mollolide A, add 195 grams of starch, mix well, and make 1000 capsules.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental Example 1: Study on the Effect of Mollolide A on the Acute Kidney Injury Model in Mice

[0022] 1. Establishment of cisplatin-induced acute kidney injury model in mice: Male Kunming KM mice, 16-18 g, were randomly divided into solvent control group, cisplatin model group, and administration group according to body weight, a total of 6 groups, each group 8 only. The control group was intraperitoneally injected with normal saline, and cisplatin was dissolved in normal saline and injected intraperitoneally at 7 mg / kg. The compound of the present invention was orally administered 2 days before the injection of cisplatin, once a day, for a total of five times; the positive control drug, Benazepril (K), was orally administered at the same time as the injection of cisplatin, once a day, for a total of five times. Three times of administration (administration started 2 days before the injection of cisplatin is less effective than simultaneous administration, and t...

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PUM

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Abstract

The invention discloses application of a compound Mollolide A to prepare medicines for treating and / or preventing renal insufficiency, and belongs to the technical field of medicine new application, and the application is disclosed for the first time. Because the skeleton type belongs to a bran-new skeleton type and Mollolide A has strong inhibition activity on renal insufficiency, prominent substantive features are possessed, and also notable progress is evidently possessed in prevention of renal insufficiency.

Description

technical field [0001] The present invention relates to a new application of compound Mollolide A, in particular to the application of Mollolide A in the preparation of drugs for treating renal insufficiency. Background technique [0002] Chronic kidney disease (including various chronic nephritis, diabetic nephropathy and hypertensive renal damage, etc.) is the most common chronic refractory disease. Renal tissue lesions will gradually progress from early lesions to advanced lesions of glomerulosclerosis and / or interrenal fibrosis. If not treated effectively, it will eventually lead to chronic renal insufficiency and irreversible end-stage renal failure (ie uremia). Benazepril and Losartan are currently clinically used to treat renal insufficiency, but they mainly rely on imports. These drugs are expensive and have relatively high toxicity and side effects. Such as causing some patients hyperkalemia, insurmountable cough, blood pressure lowering effect is not strong enoug...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P13/12
Inventor 吴文渊
Owner 徐海军