Danshilitong tablet preparation method and application of Danshilitong tablets in preparation of lymphoid neoplasm cell P388D1 proliferation inhibition drugs

A Danshitongli tablet and its extraction technology are applied in the preparation of drugs for inhibiting the proliferation of mouse lymphoid tumor cell P388D1 cells. In the field of preparation of Danshitongli tablet, it can solve the problems of large dosage for patients, affecting application, rough process, etc. , to achieve the effect of reducing the dosage

Inactive Publication Date: 2014-04-30
JINAN XINQIDIAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no gallstone tongli capsule that adopts ultrafine pulverization, CO 2 There are reports on supercritical extraction, microwave technology and macroporous resin adsorption technology. However, the traditional Chinese medicine is directly extracted by powdering and decocted in water. The process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. products in clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, and add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; after extraction, frankincense, myrrh residue and other nine medicinal materials are crushed, added with 3.6L of 70% ethanol, and put into a microwave extraction device for extraction. Microwave extraction, extraction power 700W, extraction 2 times, 8 minutes e...

Embodiment 2

[0034] Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, and add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the extracted frankincense, myrrh residue and other nine herbs are crushed, added 3.6L of 70% ethanol, and put into a microwave extraction device for extraction. Microwave extraction, extraction power 600W, extraction 2 times, 8 minutes each time, combined extr...

Embodiment 3

[0037] Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, and add to CO 2In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 220min, and the supercritical extract is obtained for later use; the extracted frankincense, myrrh residue and other nine herbs are crushed, added with 3.6L of 70% ethanol, and put into a microwave extraction device for extraction. Microwave extraction, extraction power 800W, extraction 2 times, 10 minutes each time, co...

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method and an application of Danshilitong tablets, wherein the Danshilitong tablets are prepared by adopting 225 g of dichondra repens forst, 225 g of artemisiacapillaris thunb, 90 g of curcuma aromatica salisb, 150 g of tangerine peel, 45 g of scutellaria baicalensis georgi, 35 g of boswellia carteri, 80 g of mirabilite, 35 g of alunite, 45 g of rheum, 45 g of common burreed tuber, 45 g of cape jasmine, 25 g of licorice root, and 35 g of myrrh as bulk drugs. According to the prevent invention, ultra-fine crushing, supercritical fluid extraction, microwave extraction and macroporous resin absorption are performed to prepare the Danshilitong tablets, such that the hesperidin content is substantially increased. The present invention further provides the application of the Danshilitong tablets in preparation of mouse lymphoid neoplasm cell P388D1 proliferation inhibition drugs.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a preparation method of Danshi Tongli Tablet and its application in the preparation of a medicine for inhibiting the proliferation of mouse lymphoid tumor cell P388D1 cells. Background technique [0002] The standard number of Danshi Tongli Capsules is WS-10324 (ZD-0324)-2002, which is recorded in the Hepatobiliary Subvolume of the National Compilation of Chinese Patent Standards. Made from 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, and 35g Myrrh. , has the effect of clearing heat and gallbladder, removing blood stasis and removing stones. For acute and chronic cholecystitis and gallstones caused by damp-heat in the liver and gallbladder. [0003] In the prior art, there is no gallstone tongli capsule that adopts ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/20A61P35/00A61P1/16A61K33/04A61K33/06
Inventor 孙波
Owner JINAN XINQIDIAN MEDICAL TECH
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