Method for surface-modifying polyurethane by using zwitterionic polymer and modified polyurethane

A zwitterion, surface modification technology, applied in the field of modified polyurethane, can solve the problems of restenosis, thrombus formation, etc., and achieve the effects of anti-platelet adsorption, high hydrophilic performance, and beneficial to endothelial cell adhesion and proliferation.

Active Publication Date: 2014-05-07
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of small-caliber artificial blood vessels, although there are various research reports on modified polyurethane, there are still shortcomings such as restenosis and thrombosis, so improving the blood compatibility of polyurethane materials is an urgent problem to be solved today.

Method used

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  • Method for surface-modifying polyurethane by using zwitterionic polymer and modified polyurethane
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  • Method for surface-modifying polyurethane by using zwitterionic polymer and modified polyurethane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for surface modification of polyurethane with zwitterionic polymers, comprising the steps of:

[0035] (1) Put 0.5cm 2 Polycarbonate polyurethane membrane (relative molecular mass is 100,000) immersed in anhydrous toluene, add lysine diisocyanate and stannous octoate, react at 60°C for 12h, take it out from the liquid, wash with anhydrous toluene, add to In 10 mL of L-cysteine ​​methanol solution with a mass concentration of 1%, react at 60°C for 12 hours; take it out, wash it with methanol, and dry it under vacuum to obtain a polyurethane containing mercapto groups on the surface introduced by L-cysteine Membrane, referred to as PCU-Cyst;

[0036] (2) Dissolve 100mg sultaine norbornene polymer (I) and 50mg benzoin isopropyl ether in 5mL mixed solvent in proportion to obtain a solution containing sultaine norbornene polymer and benzoin isopropyl ether , dropwise added to the product obtained in step (1), under the protection of nitrogen, under the protection ...

Embodiment 2

[0043] A method for surface modification of polyurethane with zwitterionic polymers, comprising the steps of:

[0044] (1) Put 1cm 2 Polycarbonate polyurethane film (relative molecular mass: 250,000) was immersed in anhydrous toluene, added 1,4-butylene diisocyanate and tin octoate, reacted at 40°C for 24 hours, removed from the liquid, washed with anhydrous toluene, Add it to 20mL of L-cysteine ​​methanol solution with a mass concentration of 0.05%, and react at 50°C for 24h; take it out, wash it with methanol, and dry it under vacuum to obtain a surface containing sulfhydryl group introduced by L-cysteine polyurethane film;

[0045] (2) Dissolve 25 mg of sultaine norbornene polymer (I) and 0.2 mg of benzophenone in 1 mL of a mixed solvent in proportion to obtain a compound containing sultaine norbornene polymer and benzophenone The solution was added dropwise to the product obtained in step (1), and under the protection of nitrogen, the click reaction was completed at 18 c...

Embodiment 3

[0048] A method for surface modification of polyurethane with zwitterionic polymers, comprising the steps of:

[0049] (1) Put 0.5cm 2 Polycarbonate polyurethane film (relative molecular mass: 20,000) was immersed in anhydrous toluene, added 1,6-hexamethylene diisocyanate and dibutyltin oxide, reacted at 80°C for 1 hour, removed from the liquid, and washed with anhydrous toluene After washing, add it to 1 mL of L-cysteine ​​methanol solution with a mass concentration of 5%, and react at 80°C for 1 h; take it out, wash it with water, and dry it under vacuum conditions to obtain a surface that is introduced by L-cysteine. Polyurethane film containing mercapto groups;

[0050] (2) Dissolve 200 mg of sultaine norbornene polymer (I) and 100 mg of 2,4-dihydroxybenzophenone in 10 mL of mixed solvent in proportion to obtain sultaine norbornene polymer and 2 , the solution of 4-dihydroxybenzophenone is added dropwise to the product obtained in step (1), and under the protection of ni...

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Abstract

The invention discloses a method for surface-modifying polyurethane by using a zwitterionic polymer and modified polyurethane. The method comprises the following steps: (1), reacting a polyurethane film with diisocyanate and then reacting with L-cysteine or sulfhydryl fatty alcohole; (2), dropwise adding a sulphobetaine-containing norbornene polymer and a photoinitiator into a product obtained in the step (1), and preparing the zwitterionic polymer-modified polyurethane by virtue of a click reation. Experiments prove that the polyurethane modified according to the method for surface-modifying the polyurethane by using the zwitterionic polymer, disclosed by the invention, is high in surface hydrophilicity, resists platelet adsorption, is low in cytotoxicity, is beneficial to endotheliaal cell adhesion and proliferation, and has better blood compatibility and biocompatibility. The modification method disclosed by the invention is simple.

Description

technical field [0001] The invention belongs to the technical field of medical polymer materials, and in particular relates to a method for modifying the surface of polyurethane with zwitterionic polymers and the modified polyurethane. technical background [0002] Medical materials usually refer to a class of natural or synthetic special functional materials that can directly contact and interact with the human body, and can treat, replace, repair or induce regeneration of cells, tissues and organs. As a biomedical material directly used in the human body, it needs to have many excellent properties, such as: ① Biological functionality: according to the specific application environment and use requirements, it should have biological functionality. For example, tissue engineering biomaterials require adhesion to cells, promotion and Induce cell proliferation and other biological functions; ②Biocompatibility, such as blood compatibility, low cytotoxicity, etc.; ③Chemical stabi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12
Inventor 冯亚凯穆萨米尔·卡恩吕娟李茜
Owner TIANJIN UNIV
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