Spinosyn/emamectin benzoate microsphere and preparation method thereof

A technology of emamectin and spinosad, which is applied in the field of pesticides to achieve the effect of reducing contact toxicity, reducing harm and improving optical stability

Inactive Publication Date: 2014-06-04
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is that the chemical structure and physical and chemical properties of spinosad and emamectin benzoate are quite different, which makes it difficult to make the compound microcapsule preparation of the two. These difficulties need to be passed through formula screening and preparation process research on the

Method used

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  • Spinosyn/emamectin benzoate microsphere and preparation method thereof
  • Spinosyn/emamectin benzoate microsphere and preparation method thereof
  • Spinosyn/emamectin benzoate microsphere and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] A preparation method of biodegradable spinosyn / emamectin benzoate microspheres, comprising the following steps:

[0037] (1) Preparation of drug-containing oil-phase suspension: mix 0.7101 g spinosad technical drug, 0.3132 g emamectin benzoate technical drug with 0.765 g polylactic acid, 0.045 g polycaprolactone, 0.09 g stearic acid was mixed, added 10 mL of dichloromethane, and dissolved in an ice-water bath to obtain a medicinal oil phase suspension; wherein, the active ingredient in the original drug of spinosad accounted for 84.5wt%, emamectin benzidine The active ingredients in the salt raw medicine accounted for 95.8%;

[0038] (2) Preparation of primary emulsion: using a high-speed homogenizer, inject the drug-containing oil-phase suspension in step (1) into 100 mL of PVA-1788 aqueous solution under the condition of homogeneous emulsion dispersion, wherein, PVA-1788 The content in the aqueous solution is 20 mg / ml, and the O / W primary emulsion is prepared; the em...

Embodiment 2

[0042] A preparation method of biodegradable spinosyn / emamectin benzoate microspheres, comprising the following steps:

[0043] (1) Preparation of drug-containing oil-phase suspension: mix 0.2034 g spinosad original drug, 0.3760 g emamectin benzoate original drug with 0.425 g polylactic acid, 0.05 g polycaprolactone, 0.025 g stearic acid was mixed, added 10 mL of dichloromethane, and dissolved in an ice-water bath to obtain a medicinal oil phase suspension; wherein, the active ingredient in the original drug of spinosad accounted for 84.5wt%, emamectin benzidine The active ingredients in the salt raw medicine accounted for 95.8%;

[0044] (2) Preparation of primary emulsion: use a high-speed homogenizer to inject the drug-containing oil-phase suspension in step (1) into 200 mL of gelatin aqueous solution under the condition of uniform dispersion of milk, wherein the gelatin in aqueous solution The content is 10 mg / ml, and the O / W primary emulsion is prepared; the emulsificati...

Embodiment 3

[0048] A preparation method of biodegradable spinosyn / emamectin benzoate microspheres, comprising the following steps:

[0049] (1) Preparation of drug-containing oil phase suspension: mix 1.42 g of spinosad original drug, 0.3132 g of emamectin benzoate original drug with 1.05 g of polylactic acid, 0.3 g of polycaprolactone, 0.15 g stearic acid was mixed, added 10 mL of dichloromethane, and dissolved in an ice-water bath to obtain a medicinal oil phase suspension; wherein, the active ingredient in the original drug of spinosad accounted for 84.5wt%, emamectin benzidine The active ingredients in the salt raw medicine accounted for 95.8%;

[0050] (2) Preparation of primary emulsion: using a high-speed homogenizer, inject the drug-containing oil phase suspension in step (1) into 150 mL of PVA-1788 aqueous solution under the condition of homogeneous emulsion dispersion, wherein, PVA-1788 The content in the aqueous solution is 15 mg / ml, and the O / W primary emulsion is prepared; t...

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Abstract

The invention discloses a biodegradable spinosyn / emamectin benzoate microsphere and a preparation method thereof. According to the microsphere prepared in the invention, a core material is wrapped with biodegradable materials such as polylactic acid, polycaprolactone, and stearic acid; the microsphere has the advantages of safety, low toxin, high efficiency, long lasting period, and good stability, and has the advantage of good environment compatibility when compared to microcapsules with polymer wall materials most used currently. Meanwhile, aiming at the problem that drug release is too fast or too slow for most products with a single wall material, the method of the invention realizes adjusting control of the microsphere slow release performance by changing the ratio of polylactic acid, polycaprolactone and stearic acid in the wall materials.

Description

technical field [0001] The invention belongs to the technical field of pesticides, and in particular relates to a biodegradable spinosad / emamectin benzoate microsphere and a preparation method thereof. Background technique [0002] Microcapsules (microcapsules) use natural or synthetic polymer materials (commonly known as wall materials) to wrap solid or liquid drugs (commonly known as core materials) into tiny capsules with a diameter of 1-500 μm (usually 5-250 μm). This kind of tiny reservoir (reservoir) structure formed by capsule material wrapping capsule core is called microcapsule. If the capsule core is dissolved or uniformly dispersed in the polymer material matrix to form a matrix type of tiny spherical entity, it is called microspheres. The preparation process of microcapsules and microspheres is collectively referred to as microencapsulation. [0003] At present, most pesticide sustained-release preparations are microcapsule preparations, and the wall materials...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/28A01N25/10A01N43/90A01P7/04A01N43/22
Inventor 吴刚张少飞陈鹏浩张飞吴祖建
Owner FUJIAN AGRI & FORESTRY UNIV
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