Multicarotenoid beadlets and related method
一种胡萝卜素、微型胶囊的技术，应用在饮食补充剂,-胡萝卜领域，能够解决降低类胡萝卜素补充剂有效性等问题
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Embodiment 1
[0043] Prepared with the above and figure 1 The relevant multi-carotenoid microcapsules having a multilayer structure and structures shown in Table 1 or other structures described below were then tested for dissolution rate. figure 2 A typical chromatogram of this continuous, time-release microcapsule is illustrated. The protocol for obtaining this data is described in Table 3 and further described below.
[0044] Table 3: Dissolution parameters and procedures
[0045]
[0046]The above aliquots of the microcapsule samples in Table 3 were subjected to high performance liquid chromatography (HPLC) analysis. Standard for HPLC analysis was ?-Carotene, Type II Synthetic, Sigma Aldrich, Cat # C4582-25MG, Lot # 120M5165V, Purity: 99.840%, supplied by Sigma Aldrich, St. Louis, Missouri . All values reported are relative to ?-carotene standards, but a different method was used for astaxanthin analysis.
[0047] To prepare the samples, aliquots were taken from each 20 mL dis...
Embodiment 2
[0053] In this example, the carotenoid component of an immediate release (IR) multicarotenoid formulation (i.e., in which the carotenoids are not layered and not released continuously, but all released simultaneously) was combined with continuous, Two embodiments of multicarotenoid microcapsules for timed release (also known as controlled release (CR)) were compared. In Table 5 below, the exact amounts of the respective carotenoids in each formulation are expressed in milligrams per gram (mg / g). Figure 3-5 Graphical immediate-release (IR) microcapsules ( image 3 ) and two embodiments of controlled release (CR) microcapsules (referred to as Prototype I ( Figure 4 ) and Prototype II ( Figure 5 )) Dissolution profile. As shown, there is a difference in the release of ?-carotene and ?-carotene between prototypes I and II.
[0054] Table 5: Composition of Immediate Release (IR) and Controlled Release (CR) Microcapsules (mg / g)
[0055] IR prototype CR Prototy...
Embodiment 3
[0058] A clinical study comparing immediate-release multi-carotenoid formulations and controlled-release carotenoid formulations was performed. The clinical study was designed based on the following. In the gut, carotenoids form multilamellar lipid vesicles, those mixed lipid micelles composed of bile salts, free fatty acids, monoglycerides, and phospholipids. Once micellized, carotenoids are generally thought to be absorbed into the duodenal mucosa by passive diffusion. Diffusion rates are determined by the concentration gradient between micelles and enterocytes. Carotenoids are transported exclusively from the intestinal mucosa into the bloodstream by chylomicrons. This provides a convenient compartmentalized type model with which to assess the absorption of carotenoids following ingestion.
[0059] Therefore, in the study, the chylomicron fraction of postprandial plasma will be assessed to determine absorption after release from two different mixed carotenoid capsule for...
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