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Salicylic acid nanostructured lipid carrier and its preparation method and application

A technology of nano-structured lipids and salicylic acid, which can be used in pharmaceutical formulations, cosmetic preparations, dressing preparations, etc. It can solve the problems of poor water solubility, inconvenience, and strong irritation of salicylic acid, so as to reduce irritation and protect the skin. Allergic reactions, improved water solubility and stability, simple, convenient and controllable preparation process

Inactive Publication Date: 2016-01-20
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a salicylic acid nano-structured lipid carrier to solve the shortcomings of salicylic acid in the prior art, such as strong irritation, poor water solubility and inconvenient direct addition to water-based cosmetics

Method used

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  • Salicylic acid nanostructured lipid carrier and its preparation method and application
  • Salicylic acid nanostructured lipid carrier and its preparation method and application
  • Salicylic acid nanostructured lipid carrier and its preparation method and application

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preparation example Construction

[0048] The preparation method of the above-mentioned salicylic acid nanostructure lipid carrier, such as figure 1 shown, including the following steps:

[0049] Step 1. Take the compound lipid material and emulsifier in the formula amount, heat and mix to obtain a liquid oil phase containing emulsifier at 55°C to 75°C;

[0050] Step 2: Take the formula amount of salicylic acid and add it into the liquid oil phase containing emulsifier in step 1, stir at 55°C to 75°C until completely dissolved, and obtain the oil phase in which salicylic acid is dissolved;

[0051] Step 3, take the deionized water of formula quantity, heat to 55 ℃~75 ℃;

[0052] Step 4. Slowly add deionized water from step 3 to the oil phase in which salicylic acid is dissolved in step 2, and shear at a high speed at 55°C to 75°C, with a shear speed of 10,000 to 13,000rpm and a shear time of 0.5 to 1min , and then through high-pressure homogenization, the homogenization pressure is 400-600 bar, and the number o...

Embodiment 1

[0056] Composition formula

[0057]

[0058] (1) Accurately weigh 5.0 grams of diethyl sebacate, 4.0 grams of glyceryl caprylate, 9.0 grams of glyceryl monostearate, and 6.0 grams of Tween 80, 4.0 grams of PEG-100 stearate, and The mixture of lipid material and emulsifier is heated and mixed to obtain a liquid oil phase containing emulsifier at 75°C;

[0059] (2) Accurately weigh 2.5 grams of salicylic acid, add it to the above-mentioned liquid oil phase containing emulsifier, stir at 75°C until completely dissolved, and obtain an oil phase in which salicylic acid is dissolved;

[0060] (3) Accurately weigh 69.5 grams of deionized water, and heat it to 75°C in a water bath;

[0061] (4) Slowly add deionized water into the oil phase dissolved in salicylic acid, shear at a high speed for 0.5min at 75°C, and select a shear speed of 10,000rpm, and then undergo high-pressure homogenization, the homogenization pressure is 600bar, and the number of homogenization For 4 times, ob...

Embodiment 2

[0065] Composition formula

[0066]

[0067] (1) Accurately weigh 6.0 grams of glyceryl caprylate, 4.0 grams of glyceryl monostearate and 5.0 grams of Olivem1000, heat and mix the lipid material and emulsifier mixture to obtain a liquid oil phase containing emulsifier at 75°C;

[0068] (2) Accurately weigh 1.0 g of salicylic acid, add it to the above-mentioned liquid oil phase containing emulsifier, stir at 75°C until completely dissolved, and obtain an oil phase in which salicylic acid is dissolved;

[0069] (3) Accurately weigh 84.0 grams of deionized water, and heat it to 75°C in a water bath;

[0070] (4) Slowly add deionized water into the oil phase dissolved in salicylic acid, shear at a high speed for 1min at 75°C, and select a shear speed of 10,000rpm, and then undergo high-pressure homogenization, the homogenization pressure is 400bar, and the number of homogenization is 3 times to obtain nanoemulsion;

[0071] (5) Stir and cool the nanoemulsion in an ice bath at...

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Abstract

The invention discloses a salicylic acid nanostructured lipid carrier, which comprises the following components in percentage by mass: 1 to 5% of salicylic acid, 10 to 30% of composite lipid material, 5 to 15% of emulsifier, and the balance of deionized water, wherein the composite lipid material is a solid-liquid lipid material, a solid lipid material is one or more of glyceryl monostearate, shea butter, acetylated monoglyceride and spermaceti wax, and a liquid lipid material is one or more of glyceryl caprylate caprate, diethyl sebacate, castor oil, and isopropyl myristate. The invention also discloses a preparation method and application of the salicylic acid nanostructured lipid carrier. Salicylic acid is embedded by a nanostructured carrier technology, so that large amounts of free salicylic acid are not in direct contact with the skin to reduce the irritation of the salicylic acid, and the release of salicylic acid is favorably controlled, and salicylic acid can be ensured to be effective at the surface concentration by utilizing controlled release and sustained release.

Description

technical field [0001] The invention relates to the technical field of carrier systems in cosmetic preparation technology, in particular to a salicylic acid nanostructured lipid carrier and its preparation method and application. Background technique [0002] Salicylic acid, also known as o-hydroxybenzoic acid, is a β-hydroxy acid substance with molecular formula C 7 h 6 o 3 , with a molecular weight of 138, usually widely exists in the natural sweet birch, willow bark and white pearl leaves in the form of free and glucoside. At present, in industry, salicylic acid is mainly prepared by synthesizing salicylic acid sodium salt with phenol and carbon dioxide under high temperature and high pressure reaction conditions according to the Kelber-Schmidt reaction and then sulfating it. [0003] Salicylic acid has the function of physiological regulation, and can be widely used in agriculture, medicine, chemical industry and other industries as pharmaceutical intermediates and fi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/02A61K8/06A61K8/368A61Q19/00
Inventor 夏强黄一清
Owner SOUTHEAST UNIV
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