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Experimental method of influences of acupuncture on hypertension angiocarpy variability caused by rat stress

An experimental method, high blood pressure technology, applied in the field of hypertension research, can solve the problems of lack of blood pressure volatility, baroreflex sensitivity research, etc.

Inactive Publication Date: 2014-06-25
HUZHOU TEACHERS COLLEGE
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Problems solved by technology

[0005] The purpose of the embodiment of the present invention is to provide an experimental method for the effect of acupuncture on the cardiovascular variability of stress-induced hypertension in rats, aiming to solve the existing lack of acupuncture on blood pressure fluctuation and baroreflex sensitivity in hypertensive patients research question

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  • Experimental method of influences of acupuncture on hypertension angiocarpy variability caused by rat stress

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Embodiment 1

[0029] Animals were divided into (1) sham operation (sham) group; (2) ovariectomized (OVX) group; (3) ovariectomized (OVX) + electroacupuncture (EA) group; Stress (without stress) group. The stress group received plantar electric shock combined with electric cicada sound stress treatment in the last two weeks. After the stress was over, the femoral artery was intubated, heart rate (HR), blood pressure (BP) were recorded, and heart rate variability (HRV) and baroreflex sensitivity were measured. sex (BRS) analysis.

[0030] (1) Experimental animals and materials Experimental animals: healthy female SD rats, 4 months old, weighing 200-250 g (provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences); experimental drugs: pentobarbital sodium; main experimental instruments: electroacupuncture (No. 32 stainless steel needle), electroacupuncture treatment instrument (G6805-2 type, Shanghai Medical Devices High-Tech Co., Ltd.), etc.

[0031](2) Experime...

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Abstract

The invention discloses an experimental method of influences of acupuncture on the hypertension angiocarpy variability caused by rat stress. Animals are divided into a sham operation set, an ovariectomized set and an ovariectomized and electric acupuncture set; each set is further divided into a stress set and a non-stress set. Stress is carried out on rats receiving stress processing combining foot shock and electric cicadas in the two final weeks, femoral artery canula inserting is carried out after the stress is completed, the heart rate and the blood pressure are recorded, and the heart rate variability analysis and the baroreflex sensitivity analysis are carried out. The Zusanli points of the ovariectomized rats with hypertension caused by the stress are electrically acupunctured to give play to the antihypertensive effect by improving the autonomic nervous function and increasing the sensibility of cardiovascular systems on autonomic nerve adjustment. By means of the experimental method, a basis is provided for precise curative effects of the hypertension acupuncture treatment, a new breakthrough is found for mechanism researching on hypertension and cardiovascular disease acupuncture treatment, and the antihypertensive effect is achieved by improving the autonomic nervous function and increasing the sensibility of the cardiovascular systems on autonomic nerve adjustment through the fact that the Zusanli points of the ovariectomized rats with the hypertension caused by the stress are electrically acupunctured.

Description

technical field [0001] The invention belongs to the technical field of hypertension research, and in particular relates to an experimental method for the effect of acupuncture on the cardiovascular variability of stress-induced hypertension in rats. Background technique [0002] Essential hypertension (essentialhypertension, EH) is a syndrome in which elevated blood pressure is the main clinical manifestation with or without multiple risk factors. It is usually referred to as hypertension, also known as hypertension. Hypertension is one of the common cardiovascular diseases. It is also a cardiovascular disease with a long history, the most widespread, the most harmful, and the most hidden in our country. It is closely related to the main diseases of human death, such as coronary heart disease and cerebrovascular disease. [0003] In recent years, there have been many clinical studies on acupuncture treatment of hypertension, and the curative effect of acupuncture on hyperten...

Claims

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Application Information

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IPC IPC(8): A61D1/00
Inventor 沈志坤朱敏礼
Owner HUZHOU TEACHERS COLLEGE
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