A kind of composite biomaterial application and preparation method

A technology of composite biomaterials and biomaterials, applied in medical science, bandages, absorbent pads, etc., can solve the problems of unfavorable wound repair and high production cost, achieve good safety and biocompatibility, fast wound healing and repair, Strong antibacterial effect

Active Publication Date: 2016-05-18
JILIN WANHUI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the existing products, in terms of sterility protection, most of them are isolated from the outside world. Once bacteria invade, it is not conducive to wound repair; some of them are artificially added chemical antibacterial drugs, which have certain side effects and high production costs.

Method used

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  • A kind of composite biomaterial application and preparation method
  • A kind of composite biomaterial application and preparation method
  • A kind of composite biomaterial application and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] See figure 1 , A medical sanitary wound dressing, composed of a base layer 1, a wound protective layer 2 and two peeling layers 3. The wound protective layer 2 is closely attached to the center of one side of the base layer 1, and the two peeling layers 3 One end is partially overlapped and covered on the wound protection layer 2 to protect the wound protection layer. The other ends of the two peeling layers 3 are bonded to the two ends of the base layer 1 for easy peeling during use. The base layer 1 and the wound protection layer 2 The corrugated non-woven medical breathable adhesive tape with a glue layer on the surface of the laminated side. The wound protection layer 2 is a composite biological material prepared by the method of the present invention. The composite biological material includes a silk fibroin porous biological material and a chitosan , Micron-sized inorganic powder particles. The peeling layer 3 is a release paper, such as glassine paper.

Embodiment 2

[0031] Example 2 Preparation method of wound protection layer

[0032] (1) Raw silk degumming: configure 1% soapy water lotion, which contains 0.5% NaHCO by mass 3 , Soak the raw silk in it, the weight ratio of silk to the solution is 1:25, the soaking temperature is 70℃, the soaking time is 40 minutes, cleaning with deionized water, the water temperature is 70℃, the constant temperature is soaked for 40 minutes, the silk is loosened and air-dried at room temperature. To spare

[0033] (2) Preparation of silk fibroin porous biological material: the material obtained in step (1) is coarsely opened; the speed is 0.20Hz fed into the transmission mode to blend; the speed is 0.20Hz for fine opening; through the vacuum with metering pump For transfer box transfer, the conditions for controlling the vacuum transfer box are: the main cylinder speed is 20Hz, the doffer speed is 20Hz, and the chaotic speed is 14Hz; double-layer carding, the carding conditions are the cotton feeding speed of ...

Embodiment 3

[0040] Example 3 Preparation process of wound protective layer

[0041] (1) Raw silk degumming: configure 1% soapy water lotion, which contains 0.5% NaHCO by mass 3 , Soak the raw silk in it, the weight ratio of silk to the solution is 1:25, the soaking temperature is 90℃, the soaking time is 60 minutes, clean with deionized water, the water temperature is 90℃, soak at constant temperature for 60 minutes, loosen the silk, and air dry at room temperature. To spare

[0042] (2) Preparation of silk fibroin porous biological material: the material obtained in step (1) is coarsely opened; the speed is 0.40Hz fed into the transmission mode to blend; the speed is 0.40Hz for fine opening; through the vacuum with metering pump For transfer box transfer, the conditions for controlling the vacuum transfer box are: the main cylinder speed is 30Hz, the doffer speed is 30Hz, and the chaotic speed is 19Hz; for double-layer carding, the carding condition is 0.4Hz for cotton feeding speed and 10Hz ...

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Abstract

The invention provides a composite biological material patch. The composite biological material patch consists of a base body layer, a wound protecting layer and two release layers, wherein the wound protecting layer is tightly adhered to the center position at one side of the base body layer; one end part of each of the two release layers is covered on the wound protecting layer after being superposed; the wound protecting layer is made from a composite biological material which comprises a silk fibroin porous biological material, chitosan and micro-level inorganic powder particle. By virtue of a combination method of opening, carding, lapping and spunlace and a spraying method, the wound protecting layer is prepared by compounding three substances. The composite biological material patch disclosed by the invention belongs to natural biological material wound patch products, has good biocompatibility, is suitable for various wounds such as burns, scalds and operative incisions, can be used for reducing scars while promoting tissue healing and wound repairing, and has the effect of restraining bacteria on the wound surface from growing; moreover, the composite biological material patch has good flexibility, expansibility and gas permeability, and has stronger bacteriostatic action.

Description

Technical field [0001] The invention belongs to the field of medical materials, and relates to a composite biomaterial application for wound repair, healing promotion and antibacterial. Its main components are silk fibroin, chitosan, and micron-level inorganic powder materials mixed in a certain proportion. Composite biological materials. It is suitable for various wounds and post-operative wounds with antibacterial and anti-inflammatory, hemostasis, promotion of tissue healing and repair, and reduction of scars. Background technique [0002] In clinical treatment of wounds, in addition to surgical treatment, various nano- to micron-scale inorganic powder materials that promote wound repair are also used. Commonly used clinically are skin health, special skin health, etc., and then use various medical sanitary care on the surface of the wound. Create products. When used for the healing treatment of acute and chronic skin wounds, this product is a sterile microparticle powder be...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61L15/26A61L15/32A61L15/42A61L15/18A61L15/44
Inventor李大为
OwnerJILIN WANHUI BIOLOGICAL TECH CO LTD