Supercharge Your Innovation With Domain-Expert AI Agents!

A preparation method of biomimetic drug-loaded gradient slow-release bone scaffold based on nanomaterials

A nanomaterial and bone scaffold technology is applied in the field of preparation of novel biomimetic drug-loaded graded sustained-release bone scaffolds, which can solve the problems of high burst release and unreasonable drug-loading methods in bone scaffolds, so as to improve the success rate and promote osteoblasts. The effect of differentiation

Inactive Publication Date: 2015-08-12
SHANGHAI UNIV
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The unreasonable drug loading method of the bone scaffold makes the drug accumulate on the surface of the bone scaffold, resulting in a higher burst release

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A preparation method of biomimetic drug-loaded gradient slow-release bone scaffold based on nanomaterials
  • A preparation method of biomimetic drug-loaded gradient slow-release bone scaffold based on nanomaterials
  • A preparation method of biomimetic drug-loaded gradient slow-release bone scaffold based on nanomaterials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0026] The present invention will be described below through specific examples, which are described in detail in conjunction with the accompanying drawings as follows:

[0027] Such as figure 1 As shown, a method for preparing a biomimetic drug-loaded gradient slow-release bone scaffold based on nanomaterials, the process steps are as follows:

[0028] 1) Design and manufacture of negative type a and negative type b

[0029] Use CATIA V5R19 (France, Dassault System) to design two negative types, namely negative a and negative b. The negative type includes three components, namely the base, the left half ring and the right half ring. There is a groove at the bottom of the negative type b to facilitate the vertical loading of the icicles and avoid the icicles toppling. Negative components are manufactured with the help of fusion accumulation molding technology. The negative three-dimensional solid model is saved in STL format and imported into the fusion accumulation molding ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a nano material-based bionic drug-loaded gradient slow release bone scaffold. The preparation method comprises following steps: preparation of a negative die; preparation of a slurry; preparation of an inner layer drug-loaded bone scaffold; preparation of an outer layer drug-loaded bone scaffold; packaging; and the like. The nano material-based bionic drug-loaded gradient slow release bone scaffold is capable of satisfying requirements of common bone scaffolds on porosity, strength, and surface morphology; bone scaffold drug-loading diversity is achieved; gradient slow release of loaded drugs is realized; success rate of complex bone defect treatment in clinic is increased effectively; and application prospect in clinic is promising.

Description

Technical field [0001] The present invention provides a method for preparing a novel bionic drug-loaded graded slow-release bone scaffold, in particular a method for preparing a biomimetic drug-loaded graded slow-release bone scaffold based on nano materials. Background technique [0002] At present, in clinical bone defect repair methods, the application of tissue engineering technology and the use of bionic bone made of biomaterials is one of the best alternatives to autologous bone grafting in solving the problem of insufficient bone source. [0003] Melt accumulation molding technology is one of additive manufacturing technologies. The technology is to heat and melt thermoplastic polymer materials into filaments, which are stacked on the molding surface to form. The molding speed and accuracy are high, and it can be used to make molds with complex internal structures. Biomanufacturing is a cross-technology of manufacturing science, life science, and material science. Engineerin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61L27/40A61L27/50A61L27/54
Inventor 高海涛林柳兰董洋洋陆宇杰胡庆夕
Owner SHANGHAI UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com