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Antibacterial antipruritic cream and its preparation method and application

A technology of antibacterial and antipruritic cream, which is applied in the field of antibacterial antipruritic cream and antibacterial antipruritic cream for external use on the skin. It can solve the problem of short-term effective treatment effect and achieve the effect of changing unsafe and safe use

Inactive Publication Date: 2016-03-02
SHANGHAI LUGUAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The therapeutic effect is effective in the short term, but long-term use will cause serious side effects

Method used

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  • Antibacterial antipruritic cream and its preparation method and application
  • Antibacterial antipruritic cream and its preparation method and application
  • Antibacterial antipruritic cream and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This embodiment relates to an antibacterial and antipruritic cream for external use on the skin and its preparation method:

[0026] The antibacterial and antipruritic cream for external use on the skin is composed of the following raw materials in mass percentage:

[0027]

[0028] The preparation method, such as figure 1 shown, including the following steps:

[0029] Step (1) Dissolve the antibacterial agent quaternary ammonium-73 with 1,3-butanediol in advance, heat to 85°C, stir and dissolve until uniform, and cool to 50°C; use 1,3-butanediol to dissolve the antipruritic agent Dissolve dihydrooatyl anthranilic acid D, heat to 65°C, stir to dissolve until uniform, and cool to 50°C;

[0030] Step (2) Weigh glycerin according to the above ratio, add water to it and stir evenly to obtain phase B;

[0031] Step (3) Weigh the emulsifier, mixed alcohol, glyceryl monostearate and petrolatum respectively according to the above ratio, and mix them to obtain phase A. The...

Embodiment 2

[0038] This embodiment relates to an antibacterial and antipruritic cream for external use on the skin and its preparation method:

[0039] The antibacterial and antipruritic cream for external use on the skin is composed of the following raw materials in mass percentage:

[0040]

[0041] The preparation method, such as figure 1 shown, including the following steps:

[0042] Step (1) Dissolve the antibacterial agent quaternary ammonium salt-73 in propylene glycol in advance, heat to 80°C, stir and dissolve until uniform, and cool to 51°C; use 1,2-pentanediol to dissolve the antipruritic agent Benzoic acid D is dissolved, heated to 70°C, stirred and dissolved until uniform, cooled to 51°C;

[0043] Step (2) Weigh glycerin according to the above ratio, add water to it and stir evenly to obtain phase B;

[0044] Step (3) Weigh the emulsifier, mixed alcohol, glyceryl monostearate and petrolatum respectively according to the above ratio, and mix them to obtain phase A materi...

Embodiment 3

[0051] This embodiment relates to an antibacterial and antipruritic cream for external use on the skin and its preparation method:

[0052] The antibacterial and antipruritic cream for external use on the skin is composed of the following raw materials in mass percentage:

[0053]

[0054] The preparation method, such as figure 1 shown, including the following steps:

[0055] Step (1) Dissolve the antibacterial agent quaternary ammonium salt-73 with 1,2-pentanediol in advance, heat to 82.5°C, stir and dissolve until uniform, cool to 52°C; use 1,3-butanediol to dissolve the antipruritic agent Dissolve dihydrooatyl anthranilic acid D, heat to 60°C, stir to dissolve until uniform, and cool to 52°C;

[0056] Step (2) Weigh glycerin according to the above ratio, add water to it and stir evenly to obtain phase B;

[0057] Step (3) Weigh the emulsifier, mixed alcohol, glyceryl monostearate and petrolatum respectively according to the above ratio, and mix them to obtain phase A ...

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Abstract

The invention provides bacteria-inhibiting and itching-relieving cream for external application of skin, a preparation method and an application thereof. The bacteria-inhibiting and itching-relieving cream comprises the following raw materials in percentage by mass: 1-3 percent of emulsifier, 1-10 percent of mixed alcohol, 1-3 percent of glycerin monostearate, 6-10 percent of mineral oil, 1-6 percent of propylene glycol, 0.001-0.01 percent of an antibacterial agent quaternary ammonium salt-73, 0.02-0.15 percent of an antipruritic agent dihydro-oat acyl o-aminobenzoic acid D and the balance of water. The preparation method comprises the following steps: pre-dissolving an antibacterial agent and an antipruritic; preparing a B-phase material containing glycerinum; preparing an A-phase material consisting of the emulsifier, the mixed alcohol, the glycerin monostearate and Vaseline; heating and mixing the B-phase material and the A-phase material, and stirring; and adding a C-phase material, and uniformly stirring. The cream does not contain antibiotics and corticosteroids (steroid hormone), has a remarkable effect of inhibiting bacteria and relieving itching, and is safe to use.

Description

technical field [0001] The invention relates to the technical field of an antibacterial and antipruritic cream for external use on the skin, in particular to an antibacterial and antipruritic cream. Background technique [0002] Currently, there are a variety of antibacterial and antipruritic creams for skin on the market. These medicated cream products mainly treat athlete's foot, dandruff, psoriasis, eczema, lichen planus, lupus erythematosus, neurodermatitis and impetigo and other diseases. The therapeutic effect is effective in the short term, but long-term use will cause serious side effects. This is because most of these products contain drugs such as antibiotics and corticosteroids. Antibiotics are used to treat various bacterial infections or to inhibit pathogenic microbial infections. Excessive use will inhibit the beneficial bacteria in the body and make the flora unbalanced. [0003] Corticosteroid (steroid hormone) creams can cause irritation such as erythema,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/427A61K9/06A61P31/04A61P17/04A61P31/10A61P17/00A61P17/10A61K31/196
Inventor 苏东亮
Owner SHANGHAI LUGUAN BIOTECH
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