Medicinal composition for treating ectopic pregnancy and preparation method thereof

A composition and ectopic pregnancy technology, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., can solve the problems of low content of drug active ingredients, large side effects of chemotherapy drugs, and inability to effectively extract, etc., to restore the fallopian tubes Unobstructed, significant curative effect, and improved utilization of medicinal materials

Inactive Publication Date: 2014-07-23
夏先枝
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgical treatment has a lot of trauma to patients, high cost, large side effects of chemotherapy drugs, and incomplete treatment. In the prior art, patent 201110107664.4 discloses a traditional Chinese medicine preparation for treating ectopic pregnancy. The patented drug utilizes the ability to inhibit trophoblast cells, kill Drugs that act on embryos: Trichosantha Fensis and Hedyotis diffusa are the main drugs, and the auxiliary drugs are mainly medicinal materials such as promoting blood circulation, removing blood stasis, and promoting pelvic blood circulation.
However, the preparation method of the patented drug is simple, and the volatile oil or alcohol-soluble components in the drug components cannot be effectively extracted only by water extraction or decoction.

Method used

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  • Medicinal composition for treating ectopic pregnancy and preparation method thereof
  • Medicinal composition for treating ectopic pregnancy and preparation method thereof
  • Medicinal composition for treating ectopic pregnancy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1: the preparation of capsule

[0058] Tianhuafen 68.5g, Atractylodes macrocephala 137.0g, centipede 68.5g, scorpion 82.2g, wood beetle 82.2g, madder 82.2g, triangular 82.2g, curcuma 54.8g, astragalus 54.8g, comfrey 54.8g, aurantium 68.5g, licorice 68.5g

[0059] The preparation process is:

[0060] (1) Trichosanthin slices, add 8 times the amount of water and boil 3 times, each extraction time is 3 hours, combine the decoction, concentrate, add 75% ethanol to make the alcohol content 50%, let stand for 48 hours, precipitate, combine, recovering ethanol, recovering the ethanol under reduced pressure, and obtaining the trichosanthemi extract;

[0061] (2) Extract volatile oil from ground beetle, Radix Astragali, and Atractylodes macrocephala, and store in another container;

[0062] (3) Comfrey, triangular, and centipede are heated and refluxed with 50% ethanol for 3 times, and the amount of ethanol used for the second and subsequent times is 10 times the w...

Embodiment 2

[0066] Embodiment 2: the preparation of tablet

[0067] 80g trichosanthes, 160g Atractylodes macrocephala, 80g centipede, 96g scorpion, 96g wood beetle, 96g madder, 96g trigonum, 64g curcuma, 64g astragalus, 64g comfrey, 80g aurantium, 80g licorice

[0068] The preparation process is:

[0069] (1) Trichosanthes slices, add 10 times the amount of water and boil 4 times, each extraction time is 4 hours, combine the decoction, concentrate, add 75% ethanol to make the alcohol content 60%, let stand for 60 hours, precipitate, combine, recovering ethanol, recovering the ethanol under reduced pressure, and obtaining the trichosanthemi extract;

[0070] (2) Extract volatile oil from ground beetle, Radix Astragali, and Atractylodes macrocephala, and store in another container;

[0071] (3) Comfrey, triangular, and centipede are heated and refluxed with 75% ethanol for 3 times, and the amount of ethanol used for the second and subsequent times is 15 times the weight of the medicinal m...

Embodiment 3

[0075] Embodiment 3: the preparation of granule

[0076] 50g trichosanthes, 100g Atractylodes macrocephala, 50g centipede, 60g scorpion, 60g wood beetle, 60g madder, 60g trigonum, 40g curcuma, 40g astragalus, 40g comfrey, 50g aurantium, 50g licorice

[0077] The preparation method is:

[0078] (1) Trichosanthin slices, add 5 times the amount of water and boil 4 times, each extraction time is 2 hours, combine the decoction, concentrate, add 60% ethanol to make the alcohol content 50%, let stand for 24 hours, precipitate, combine, recovering ethanol, recovering the ethanol under reduced pressure, and obtaining the trichosanthemi extract;

[0079] (2) Extract volatile oil from ground beetle, Radix Astragali, and Atractylodes macrocephala, and store in another container;

[0080] (3) Comfrey, trigonum, and centipede are heated and refluxed with 50% ethanol for 4 times, and the amount of ethanol used for the second and subsequent times is 15 times the weight of the medicinal mate...

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Abstract

The invention discloses a medicinal composition for treating ectopic pregnancy and a preparation method thereof. The medicinal composition is prepared from the following main medicinal materials and auxiliaries in parts by weight: 50-80 parts of radices trichosanthis, 100-160 parts of rhizoma atractylodis macrocephalae, 50-80 parts of centipede, 60-96 parts of scorpion, 60-96 parts of ground beetle, 60-96 parts of madder, 60-96 parts of rhizoma sparganii, 40-64 parts of curcuma zedoary, 40-64 parts of astragalus membranaceus, 40-64 parts of lithospermum, 50-80 parts of immature bitter orange and 50-80 parts of liquorice. The medicament for treating ectopic pregnancy, prepared by the extraction method is simple in extraction process steps, is suitable for industrial production, has the advantages of high content of effective components, remarkable curative effect, good effect, safety, no side effect and low production cost, is convenient to take, and is an ideal medicine for activating blood to remove stasis, tonifying qi and preventing exhaustion, and treating both symptoms and root causes of ectopic pregnancy.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating ectopic pregnancy and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Abnormal pregnancy process in which a fertilized egg implants and develops outside the uterine cavity. Also called "ectopic pregnancy". Tubal pregnancy is the most common. The etiology is often due to inflammation in or around the fallopian tube, dysplasia or dysfunction of the fallopian tube, migration of fertilized eggs, or assisted reproductive technology, etc., resulting in poor lumen patency, hindering the normal operation of pregnant eggs, making them stay and implant in the fallopian tube , development, resulting in miscarriage or rupture of tubal pregnancy. There are often no obvious symptoms before miscarriage or rupture, and there may also be menopause, abdominal pain, and a small amount of vaginal bleeding. Rupture manifested as acute ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P15/00A61K35/64A61K35/646A61K35/648
Inventor 夏先枝田华
Owner 夏先枝
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