Application of amygdalin in protecting ischemic heart

A technology of amygdalin and myocardial ischemia, applied in the application field of amygdalin, can solve problems such as increasing the activity of cytochrome oxidase, and achieve the effects of maintaining public health, increasing cardiac function and broad application prospects.

Inactive Publication Date: 2017-03-22
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

However, the specific mechanism of amygdalin anti-inflammation and increasing the activity of cytochrome oxidase in energy metabolism after ischemia has not been reported

Method used

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  • Application of amygdalin in protecting ischemic heart
  • Application of amygdalin in protecting ischemic heart
  • Application of amygdalin in protecting ischemic heart

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Experimental program
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Embodiment Construction

[0024] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0025] 1. In order to illustrate the enhancement effect of amygdalin on insulin activation signal and the protection against ischemia / reperfusion, the following models and detection methods are used:

[0026] 1.1. Preparation of rat myocardial ischemia / reperfusion (MIR) model:

[0027] After the SD rats were anesthetized by intraperitoneal injection of 30g / L pentobarbital sodium (40mg / kg), the rat MIR (30min / 3h) model was prepared according to the conventional method: the trachea was intubated through the median neck incision, and the ventilator was connected. Give artificial respiration. Left ventricular pressure and its differential were recorded by cannulating the right common carotid artery into the left ventricle. The heart was exposed by thoracotomy, and the middle and upper third of ...

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Abstract

The invention discloses application of amygdalin in protection of ischaemic heart. As found and proved by new functions, amygdalin can be used for relieving myocardial ischemia / reperfusion injury, and particularly has the function of enhancing an insulin activation 'survival signal' path central molecule Akt. Insulin resistance is the common soil of cardiovascular and cerebrovascular diseases such as diabetes, hypertension and coronary heart disease, and mainly shows as a defect of 'survival signal' path signal transduction in which Akt is taken as a key link. Amygdalin which can be used for enhancing the effect of insulin activation Akt has a possible potential wide application prospect by being used for assisting in treating diseased based on insulin resistance. By developing amygdalin into health-care products or medicaments which are rich in amygdalin, the health of people can be maintained, and cardiovascular and cerebrovascular diseases based on insulin resistance can be particularly prevented.

Description

technical field [0001] The invention belongs to the application technical field of amygdalin, and relates to the application of amygdalin to protect ischemic heart. Background technique [0002] In recent years, cardiovascular disease has become one of the main reasons that threaten human health and survival, and the incidence of myocardial infarction is also on the rise. Early thrombolytic therapy is the most ideal treatment for acute myocardial infarction, which can reduce the infarct size, improve cardiac function, and improve prognosis, but it can cause cell ischemia / reperfusion injury. [0003] Insulin is the main regulatory hormone in the process of carbohydrate and fat energy metabolism. Insulin can activate at least two known signaling pathways: one is the phosphatidylinositol 3-kinase (PI3K) pathway; the other is the mitogen-activated protein kinase (MAPK) pathway. The PI3K signaling pathway is the main signaling pathway of insulin. Studies have shown that insulin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7028A23L33/00A61P9/10A61P9/00
Inventor 董玲刘文冲高峰张海锋
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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