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Application of amygdalin in protecting ischemic heart

A technology of amygdalin and cardiac ischemia, applied in the application field of amygdalin, can solve the problems of increasing cytochrome oxidase activity, achieve the effect of maintaining public health, increasing heart function, and broad application prospects

Inactive Publication Date: 2014-10-01
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

However, the specific mechanism of amygdalin anti-inflammation and increasing the activity of cytochrome oxidase in energy metabolism after ischemia has not been reported

Method used

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  • Application of amygdalin in protecting ischemic heart
  • Application of amygdalin in protecting ischemic heart
  • Application of amygdalin in protecting ischemic heart

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Embodiment Construction

[0024] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0025] 1. In order to illustrate the enhancement effect of amygdalin on insulin activation signal and the protection against ischemia / reperfusion, the following models and detection methods are used:

[0026] 1.1. Preparation of rat myocardial ischemia / reperfusion (MIR) model:

[0027] After the SD rats were anesthetized by intraperitoneal injection of 30g / L pentobarbital sodium (40mg / kg), the rat MIR (30min / 3h) model was prepared according to the conventional method: the trachea was intubated through the median neck incision, and the ventilator was connected. Give artificial respiration. Left ventricular pressure and its differential were recorded by cannulating the right common carotid artery into the left ventricle. The heart was exposed by thoracotomy, and the middle and upper third of ...

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Abstract

The invention discloses an application of amygdalin for ischemia heart protection. The uses are based on the discovery and confirmation of the novel functions of the amygdalin: the amygdalin can relieve myocardial ischemia / reperfusion injury, and particularly has the effect of enhancing insulin to activate ''survival signal'' path central molecule Akt. Insulin resistance is a common soil of cardio-cerebrovascular diseases such as diabetes, hypertension, and coronary heart disease and is mainly manifested as the defect of ''survival signal'' path signal transduction taking the Akt as a central link. Therefore, the amygdalin capable of enhancing the Akt activation effect of the insulin can be used for the assistant treatment of insulin-resistance-based diseases, may have wide potential application prospect such as developing a health product or drug rich in the amygdalin, and can be beneficial to the health care of the common people and particularly for the prevention of insulin-resistance-based cardiovascular diseases.

Description

technical field [0001] The invention belongs to the application technical field of amygdalin, and relates to the application of amygdalin to protect ischemic heart. Background technique [0002] In recent years, cardiovascular disease has become one of the main reasons that threaten human health and survival, and the incidence of myocardial infarction is also on the rise. Early thrombolytic therapy is the most ideal treatment for acute myocardial infarction, which can reduce the infarct size, improve cardiac function, and improve prognosis, but it can cause cell ischemia / reperfusion injury. [0003] Insulin is the main regulatory hormone in the process of carbohydrate and fat energy metabolism. Insulin can activate at least two known signaling pathways: one is the phosphatidylinositol 3-kinase (PI3K) pathway; the other is the mitogen-activated protein kinase (MAPK) pathway. The PI3K signaling pathway is the main signaling pathway of insulin. Studies have shown that insulin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7028A61K38/28A61P9/10A61P5/50A23L1/29A23L33/00
Inventor 董玲刘文冲高峰张海锋
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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