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Polyhydroxy polymer embolization microspheres and its preparation process

A technology for embolizing microspheres and a preparation process, which is applied in the field of medical materials, can solve the problems of incomplete embolization of target blood vessels, damage to normal tissues, and blockage of catheters, and achieves good rapid adsorption capacity, large elastic expansion ratio and recovery performance, and operation. simple effect

Active Publication Date: 2016-10-05
SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The key to minimally invasive interventional therapy is to choose an appropriate embolic agent for blocking blood supply to tumor tissue. The physical characteristics of embolic agents are crucial to the final efficacy of interventional therapy. The size is too large, or the size distribution is too wide, and the shape is irregular. The embolic agent products of the company will lead to the following problems in interventional surgery: (1) blockage of the catheter; (2) misembolization, that is, the embolization point is too far away from the tumor tissue, causing damage to normal tissue; (3) drift, that is, the embolic agent is in the Leave the intended embolization position to enter other blood vessels after surgery; (4) The target blood vessel cannot be completely embolized
Although the obtained embolic agent can be loaded with drugs, the steps in the actual operation are cumbersome. It needs to dry the surface of the microspheres in advance, and then soak the microspheres in a solution of chemotherapeutic drugs at a temperature of 4°C for 2 hours, and then Wash with deionized water to remove unexchanged drugs on the surface before use

Method used

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  • Polyhydroxy polymer embolization microspheres and its preparation process
  • Polyhydroxy polymer embolization microspheres and its preparation process
  • Polyhydroxy polymer embolization microspheres and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Slowly add 105.1 g of aminodimethoxy acetal to a four-necked reaction flask filled with 300 mL of 15% (mass concentration) sodium hydroxide aqueous solution, stir and mix well, slowly add an equimolar amount of acryloyl chloride dropwise, and the dropwise addition ends Then continue to stir for 0.5 hours, then add saturated sodium chloride solution to the above solution, extract with methyl tert-butyl ether, and concentrate the crude product obtained by column chromatography to obtain a colorless and transparent oily product - acrylamide Methoxy acetal 90g; product structure by H 1 and C 13 Determined by nuclear magnetic resonance spectrum, the purity is determined by HPLC;

[0047] Synthesis of functionalized macromolecular hydrogel intermediates

Embodiment 2

[0049] Add molecular weight 2×10 to the flask containing 500mL pure water 4 -5×10 4 100g of polyvinyl alcohol, stirred for 10 minutes to disperse it evenly; heated up to 90-100°C, after the polyvinyl alcohol was completely dissolved, cooled down to below 25°C, then added the acrylamide prepared in Example 1 Dimethoxy acetal 1.5g, after stirring for 10 minutes, 70mL of concentrated hydrochloric acid was added dropwise to the solution. After the dropwise addition, the reaction continued to stir for 6 hours, and then the crude product was collected, washed, dehydrated, and concentrated to obtain functional The macromolecular hydrogel intermediate is stored at room temperature.

Embodiment 3

[0051] Weigh molecular weight 3×10 4 -4×10 4 Add 200g of polyethylene glycol to 500g of water and heat to 90-100 o C and stir for 2.5 hours. After the polyethylene glycol is fully dissolved, cool the solution below 25°C, add 2.0 g of butyl acrylate, and stir for 10 minutes. Add 100 mL of concentrated hydrochloric acid dropwise to the solution. After the dropwise addition, the reaction continues to stir After 4 hours, it was fully reacted. After the reaction was completed, the reaction product was dehydrated, washed, and concentrated to obtain a gel-like functionalized macromolecular intermediate, which was stored at room temperature.

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Abstract

Disclosed are a polyhydroxyl polymer embolic microsphere and a preparation process therefor. The polyhydroxyl polymer embolic microsphere is formed by cross-linking polymerization of biocompatible functional macromolecules. The functional macromolecule comprises: an acetal structure comprising at least two groups containing acrylic acid or a derivative thereof connected on the main chain or a polymer at least comprising two cross-linkable micromolecules which are connected in a covalent bond mode and have the structure of acrylic acid or a derivative thereof. The acetal structures or crosslinkable micromolecules can form a hydrogel unsaturated functional group through free radical polymerization crosslinking, and a functional group using an organic acid radical as a negative charge carrier is contained inside the microsphere. The embolic microsphere can be used for a minimally invasive treatment.

Description

technical field [0001] The invention relates to an embolization microsphere used for intervention therapy to treat tumor diseases and a preparation process thereof, belonging to the technical field of medical materials. Background technique [0002] Minimally invasive interventional therapy is becoming more and more widely used in the field of medical technology, especially in the treatment of cancer tumors rich in blood vessels such as liver cancer, kidney cancer, and uterine fibroids, and has become an important tool for the treatment of tumors that cannot be surgically removed. preferred alternative to . The principle is to use high-definition medical imaging equipment to guide the catheter through the artery to the tumor site in the human body, and then perfuse the catheter with anti-tumor drugs and embolic agents to block the blood supply of the tumor tissue, so that the tumor shrinks in a short time. Therapeutic purposes of necrosis. The key to minimally invasive int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/045A61L31/06A61L31/04A61L31/14
CPCC08F220/52A61K47/50A61L31/04A61L31/10A61L31/14A61L31/16
Inventor 姚飞王丹雄丘茹惠孙小薇
Owner SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD