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Chlamydia antigen compositions and uses thereof

A composition and technology of Chlamydia are applied in the field of peptides and polypeptides against Chlamydia infection, and can solve problems such as inability to develop

Inactive Publication Date: 2014-08-13
THE UNIV OF BRITISH COLUMBIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Specifically, DCs exposed to live C.murium became mature and stimulated antigen-specific CD4 T cells, whereas DCs exposed to dead C.murium were inhibited and failed to develop a mature phenotype

Method used

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  • Chlamydia antigen compositions and uses thereof
  • Chlamydia antigen compositions and uses thereof
  • Chlamydia antigen compositions and uses thereof

Examples

Experimental program
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Effect test

Embodiment

[0118] Materials and Methods

[0119] Chlamydia

[0120] The Chlamydia muris mouse pneumonia (MoPn) strain Nigg was grown in Hela229 in Eagle's minimal essential medium (Invitrogen) supplemented with 10% FCS. Primary bodies (EBs) were purified by discontinuous density gradient centrifugation as previously described (Caldwell, H.D., J. Kromhout and J. Schachter. 1981. Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect Immun31 :1161-1176). Purified EBs were aliquoted and stored at -80°C in sucrose-phosphate-glutamate buffer and thawed before use. The infectivity and the number of inclusion-forming units (IFU) of purified EB were determined by using anti-EB mouse polyclonal antibody, followed by biotin-labeled anti-mouse IgG (Jackson ImmunoResearch Laboratories) and diaminobenzidine (DAB ) substrate (Vector Laboratories) immunostaining to determine (Yang, X., K.T.HayGlass and R.C.Brunham.1996.Genetically determined di...

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Abstract

The present invention provides in part peptides and polypeptides derived from Chlamydia app. The present invention also provides in part methods for treating, preventing or diagnosing Chlamydia infection using the peptides and polypeptides.

Description

[0001] Statement Regarding Federally Funded Research [0002] The research was supported at least in part by Federal Government Grant No. R01AI076483 from the National Institute of Allergy and Infectious Diseases (NIAID). The United States Federal Government may have certain rights in this invention. technical field [0003] The present invention relates to the treatment of bacterial infections. More specifically, peptides and polypeptides useful in combating Chlamydia infection are provided in part of the present invention. Background technique [0004] Chlamydia trachomatis is an intracellular pathogen responsible for over 92 million sexually transmitted infections and 8500 ocular infections per year worldwide (Starnbach, M.N. and N.R. Roan. 2008. Conquering sexually transmitted diseases. Nat Rev Immunol 8:313 -317). Sexually transmitted Chlamydia trachomatis is a major cause of long-term disease sequelae (such as infertility and ectopic pregnancy) in women (Brunham, R....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/118A61P31/04A61P37/04
CPCA61K2039/55555G01N33/56927A61K2039/55572A61K39/118A61P31/04A61P37/04A61K38/08A61K38/10
Inventor R·C·布鲁汉姆L·J·福斯特
Owner THE UNIV OF BRITISH COLUMBIA
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