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A kind of ligament support and preparation method thereof

A technology of ligament and silk fibroin, which is applied in the field of medical devices to achieve the effect of uniform microstructure

Inactive Publication Date: 2016-01-20
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above existing problems, the purpose of the present invention is to solve the defects existing in the existing ligament scaffolds, using silk fibroin composite medical polymer synthetic materials as materials, to provide a fiber orientation and uniform voids, which meet the requirements of mechanical properties Three-dimensional structured ligament scaffold and its preparation method

Method used

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  • A kind of ligament support and preparation method thereof

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preparation example Construction

[0017] Preparation of ligament stent, prepare silk fibroin solution or silk fibroin powder dispersion and medical polymer synthetic material polyvinyl alcohol (PVA) solution or polyurethane (PU) solution or polycaprolactone solution (PCL) or polyurethane ( After mixing the solution of PU) and polycaprolactone (PCL), proceed as follows:

[0018] a. Mix the silk fibroin solution or silk fibroin powder dispersion with the medical polymer synthetic material solution to obtain a mass ratio of silk fibroin to medical polymer synthetic material of 1 / 20~1 / 1. The polymer composite material has a mixed solution with a total solute mass concentration of 7% to 15%, and the mixed solution is sucked into a spinning dope tube for electrostatic spinning.

[0019] b Set up an electrospinning device, and fix the collecting wheel with the circumference of 1 to 3 times the length of the ligament to be prepared on the adjustable-speed conductive rotating body. The collecting wheel and the conductive ro...

Embodiment 1

[0027] a Mix hexafluoroisopropanol as a solvent and a 5% mass concentration of silk fibroin solution with N,N-dimethylformamide as a solvent and a 20% mass concentration polyurethane (PU) solution to obtain silk fibroin and The mass ratio of medical polymer synthetic material polyurethane (PU) is 1 / 20, the total solute mass concentration of silk fibroin and medical polymer synthetic material polyurethane (PU) is 7%, and the mixed solution is sucked into electrostatic spinning Of spinning solution tube.

[0028] b. Set up an electrospinning device, and fix the collecting wheel with a circumference of 1 times the length of the ligament to be prepared on an adjustable-speed conductive rotating body. The collecting wheel and the conductive rotating body are on the same axis, and the collecting wheel is made of electrically insulating material. , The thickness of the collecting wheel is 1mm, and the two sides of the collecting wheel are respectively attached with conductive metal disc...

Embodiment 2

[0032] a Mix hexafluoroisopropanol as a solvent with a 10% mass concentration of silk fibroin solution and dimethylacetamide as a solvent with a mass concentration of 10% polycaprolactone (PCL) solution to obtain silk fibroin and medical The mass ratio of polymer synthetic material polycaprolactone (PCL) is 1 / 10, and the total solute mass concentration of silk fibroin and medical polymer synthetic material polycaprolactone (PCL) is a mixed solution of 10%, and will be mixed The solution is sucked into the spinning dope tube for electrospinning.

[0033] b. Set up an electrospinning device, and fix the collecting wheel twice the circumference of the length of the ligament to be prepared on the adjustable-speed conductive rotating body. The collecting wheel and the conductive rotating body are on the same axis, and the collecting wheel is made of electrically insulating material. , The thickness of the collecting wheel is 3mm. The two sides of the collecting wheel are respectively ...

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Abstract

The invention relates to a ligament support containing silk fibroin compound oriented nanofiber and a preparation method thereof, and belongs to the technical field of medical apparatus and instruments. The ligament support is prepared from oriented fiber combining silk fibroin with a medical high molecular synthetic material and has a porous three dimensional structure, the mass ratio of the silk fibroin and medical high molecular synthetic material in the compound oriented fiber is (1-20):(1-1), the diameter of the compound oriented fiber is 500nm-10000nm, the thickness of the ligament is 1mm-10mm, and the width of the ligament is 1mm-15mm. The ligament support has a uniform microstructure and good biocompatibility, provides a matrix structure for growing of ligament cells, and can be used for increasing the tensile strength of the ligament due to the compound fiber orientated structure. The ligament support is simple in preparation method and convenient to operate, the preparation process is controllable, and the preparation method is suitable for preparing the ligament supports of various sections and lengths.

Description

Technical field [0001] The invention relates to a ligament stent containing silk fibroin composite orientation nanofibers and a preparation method thereof, and belongs to the technical field of medical devices. Background technique [0002] In daily work and sports, the chance of ligament injury is quite high, which directly leads to the instability of joint connections and the occurrence of joint inflammation, which has become a health problem that cannot be ignored, but the self-repair ability of ligaments is very poor. There are various ligament repair methods, including own tendon transplantation, homologous or xenogeneic tendon transplantation, and artificial ligament repair materials. Because allogeneic transplantation or xenotransplantation has problems such as insufficient sources, high risks, and immune rejection, and its clinical application is greatly restricted, the use of artificial ligament repair materials to replace damaged ligaments has become the mainstream liga...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/22A61L27/56A61L27/50D04H1/728D04H1/4382D06M13/224D06M13/144D06M13/123D06M101/10D06M101/38D06M101/30D06M101/24
Inventor 柏自奎韩素青王洪吴星火周应山顾绍金陶咏真杨红军张强许杰徐卫林
Owner WUHAN TEXTILE UNIV
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