A treatment method for subarachnoid hemorrhage and local ischemia

Abstract

The present application presents data from clinical trials of PSD-95 inhibitors administered to subjects undergoing endovascular repair of aneurysms in or affecting the central nervous system. The subject is classified according to whether the aneurysm ruptured before performing the endovascular procedure. The trial demonstrated significant benefit to subjects whether or not the aneurysm ruptured prior to performing the endovascular procedure. Surprisingly, the subjects who benefited most from treatment based on pathological and neurocognitive findings were those with ruptured aneurysms leading to subarachnoid hemorrhage. These data constitute evidence that PSD‑95 inhibitors are beneficial not only in ischemic and hemorrhagic strokes, but also in forms of bleeding in or affecting the central nervous system, particularly subarachnoid hemorrhage beneficial.

Description

[0001] Cross References to Related Applications [0002] This application is a non-provisional patent application and is entitled to US 61 / 617,001 filed March 28, 2012, US 61 / 617,001 filed December 13, 2011, US 61 / 570,264 filed 2011 Priority of patent number CA 2762338 dated December 15th. The entire contents of each of the above applications are incorporated by reference into this application. [0003] sequence listing [0004] This application includes a Sequence Listing submitted in American Standard Code for Information Interchange (ASCII) format to the EFS web online submission system, and the entire contents of this application are hereby incorporated by reference. A copy in ASCII format was generated on December 12, 2012 with the file name 427647SEQLIST.txt and a size of 15kb. Background technique [0005] About 800,000 people suffer from stroke in the United States every year, and the annual direct or indirect social loss reaches 40 billion US dollars. Stroke ranks...

AI Technical Summary

Problems solved by technology

Although the range of second-stage processes that may be involved in brain injury after subarachnoid hemorrhage is widely recognized, the exact role of a single mechanism during the acute injury period is not fully understood

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