Preparation and application of novel dendritic compound containing acetylcysteine structure

A kind of technology of acetylcysteine ​​and compound, applied in the field of preparation of novel dendrimer

Inactive Publication Date: 2014-10-22
韩冰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the treatment of brain injury with this new chemical structure.

Method used

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  • Preparation and application of novel dendritic compound containing acetylcysteine structure
  • Preparation and application of novel dendritic compound containing acetylcysteine structure
  • Preparation and application of novel dendritic compound containing acetylcysteine structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A

[0033] 1) The dendrimer A5g containing a hydroxyl end was dissolved in 5ml of phosphate buffer;

[0034] 2) Dissolve acetylcysteine ​​B5g in 3ml phosphate buffer;

[0035] 3) N,N-diisopropylethylamine was dissolved in phosphate buffer and nitrogen gas was passed through, B was put into it, and 1-ethyl-3-(3- Dimethylaminopropyl) carbodiimide 2g, low temperature reaction 60 minutes;

[0036] 4) Put the product of the first step into the solution of the third step, stir and react at 600rpm for 3 hours; the purified product C,

Embodiment B

[0038] 1) The dendrimer A5g containing a hydroxyl end was dissolved in 10ml of phosphate buffer;

[0039] 2) Dissolve acetylcysteine ​​B5g in 8ml phosphate buffer;

[0040] 3) N,N-diisopropylethylamine was dissolved in phosphate buffer and nitrogen gas was passed through, B was put into it, and 1-ethyl-3-(3- Dimethylaminopropyl) carbodiimide 0.1g, low temperature reaction 30 minutes;

[0041] 4) Put the product of the first step into the solution of the third step, stir and react at 200rpm for 2 hours; the purified product C,

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Abstract

The invention discloses a preparation method of a novel dendritic compound containing an acetylcysteine structure, and application of the novel dendritic compound to traumatic cerebral injury and ischemic cerebral injury. The novel compound has extremely substantial effect when being applied to prepare medicines for treating traumatic cerebral injury and ischemic cerebral injury.

Description

technical field [0001] The present invention relates to a novel dendritic compound containing acetylcysteine ​​structure which can treat traumatic and ischemic brain injury diseases. Preparation method, and its effect on traumatic brain injury and ischemic brain injury. The novel compound has very remarkable effects in the preparation of medicines for treating traumatic brain injury and ischemic brain injury. Background technique [0002] The morbidity, disability and mortality of ischemic brain injury in my country are very high. The ischemic hypoxic necrosis of brain tissue cells caused by cerebral ischemia and hypoxia is one of the main diseases that seriously endanger human health. . Ischemic brain injury is an extremely complex pathophysiological process. At present, the drugs commonly used in clinical treatment of ischemic brain injury, such as antiplatelet drugs, anticoagulant drugs, thrombolytic drugs, defibrinating drugs, and some traditional Chinese medicine trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K31/795A61P25/00A61P9/10
Inventor 韩冰高洁
Owner 韩冰
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