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Method for cleaning penicillin bottle rubber plug

A technology for rubber stoppers and vials, applied in liquid cleaning methods, cleaning methods and utensils, chemical instruments and methods, etc., can solve the problem of poor removal of various pollutants such as packaging fibers, endotoxins and lubricating oils problem, to achieve the effect of simple and easy to operate cleaning method and efficient removal

Inactive Publication Date: 2014-11-12
AUSTAR HANSEN LIFESCI SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the defects in the prior art that the rubber stopper of the vial cannot be well removed from various pollutants such as packaging fiber, endotoxin and lubricating oil, and provide a new type of rubber stopper for the vial. the cleaning method

Method used

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  • Method for cleaning penicillin bottle rubber plug

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Dilute the cleaning agent to 1% (volume percentage), and wash the rubber stopper of the vial in a rubber stopper cleaner for 3 hours; the washing conditions are as follows: washing temperature is 55°C, pH value is 13.5, and the stirring speed during washing is 50 rpm;

[0024] The cleaning agent is a cleaning agent of the model CIP100 of STERIS Corporation of the United States, which includes the following components: 10%-30% potassium hydroxide and 1%-5% tetrasodium EDTA (CAS No. 64-02-8), the percentages stated are percentages by weight.

Embodiment 2

[0026] Dilute the cleaning agent to 0.4% (volume percentage), and wash the rubber stopper of the vial in the rubber stopper cleaner for 2 hours. The washing conditions are as follows: washing temperature is 50°C, pH value is 7, and the stirring speed during washing is 40rpm;

[0027] The cleaning agent is a cleaning agent of the model CIP100 of STERIS Corporation of the United States, which includes the following components: 10%-30% potassium hydroxide and 1%-5% tetrasodium EDTA (CAS No. 64-02-8), the percentages mentioned are percentages by weight;

Embodiment 3

[0029] Dilute the cleaning agent to 4.7% (volume percentage), and wash the rubber stopper of the vial in a rubber stopper cleaner for 5 hours. The washing conditions are as follows: washing temperature is 60°C, pH value is 9, and the stirring speed during washing is 60 rpm;

[0030] The cleaning agent is a cleaning agent of the model CIP100 of STERIS Corporation of the United States, which includes the following components: 10%-30% potassium hydroxide and 1%-5% tetrasodium EDTA (CAS No. 64-02-8), the percentages mentioned are percentages by weight;

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Abstract

The invention discloses a method for cleaning a penicillin bottle rubber plug. The method comprises the following step: a cleaning agent is diluted to 0.4%-4.7%, and the penicillin bottle rubber plug is cleaned for 2 h-5 h in a solution with alkaline pH at the temperature of 50 DEG C-60 DEG C, and at the stirring speed of 40 rpm-60 rpm, wherein the percentage is percent by volume, and the model of the cleaning agent is CIP100 of STERIS company. The method for cleaning the penicillin bottle rubber plug is simple and easy to operate and can remove pollutants such as packaging fiber, endotoxin, lubricating oil and the like efficiently.

Description

technical field [0001] The invention relates to a cleaning method for rubber stoppers of vials. Background technique [0002] Vials are also borosilicate glass or soda-lime glass-controlled (molded) injection bottles. In the early days, penicillin was often filled with them, so they were named vials. Vials made of borosilicate are the mainstream products on the market. The neck of the vial is thinner, and the thickness below the neck is the same. The mouth of the bottle is slightly thicker than the neck of the bottle and slightly thinner than the body of the bottle. It is generally used for the packaging of vaccines, biological agents, powder injections, freeze-dried and other medicines. Due to the special purpose of the vial, it has particularly high requirements on sealing performance and cannot be polluted. Therefore, the requirements for rubber stoppers of vials are very high. [0003] However, the rubber stopper of vials will be accompanied by a large amount of rubb...

Claims

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Application Information

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IPC IPC(8): B08B3/08B08B3/10
CPCB08B3/08B08B3/10B08B3/102
Inventor 何国强
Owner AUSTAR HANSEN LIFESCI SHANGHAI
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