Application for regulating double-side blood-brain barrier permeability through medical diagnosis ultrasonic wave stimulation microbubbles

Abstract

The invention discloses the application for regulating double-side blood-brain barrier permeability through medical diagnosis ultrasonic wave stimulation microbubbles. According to the method, the double-side blood-brain barrier permeability is effectively, reversibly and briefly regulated based on the biological effect generated by ultrasonic wave stimulation microbubble contrast media under the synergistic effect of different biological effects, and the effect of promoting conveying of medicine crossing micro-vessels is achieved; brief regulating of the blood-brain barrier permeability is characterized in that three layers of the micro-vessels are connected and opened closely, and therefore the concentration of the medicine crossing the micro-vessels and entering the brain tissue is improved, and the effects of the medicine can be developed. The application for regulating the double-side blood-brain barrier permeability through the medical diagnosis ultrasonic wave stimulation microbubbles is firstly proposed, the biological effect of the medical diagnosis ultrasonic wave stimulation microbubble contrast media of the application can be developed to the maximum on the basis of safety and economy, and more conveying ways are provided for the diagnosis of dispersing growing, infiltrating growing and even diffusing growing type brain tissue structure diseases in the cranium and the treatment by the medicine crossing the micro-vessels.

Description

technical field [0001] The invention relates to the field of medicine, especially the technical field of bilateral blood-brain barrier permeability and trans-microvascular treatment, and specifically relates to the use of medical diagnostic ultrasound to excite microbubbles to regulate the bilateral blood-brain barrier permeability. Background technique [0002] In clinical medical diagnostic ultrasound, it has been widely used in the diagnosis and evaluation of clinical treatment of diseases related to various organs of the body such as abdomen, gynecology, urology, transplanted organs, superficial tissues, small organs, and cardiovascular. For intracranial diffuse, infiltrating, and even diffusely growing brain tissue structural disease lesions, due to the microenvironment of the intracranial blood-brain barrier microvascular regulation barrier, most macromolecular drugs and most therapeutic nerve growth factors are restricted intervention, which in turn limits the efficac...

AI Technical Summary

Problems solved by technology

At present, there have been researches and pre-clinical experimental studies on regulating the permeability of the blood-brain barrier using self-made focused ultrasound in different modes at home and abroad. There are very few technologies that can temporarily regulate the bilateral blood-brain barrier. How to effectively and reversibly regulate the permeability of the bilateral blood-brain barrier is a technical field for drug delivery across the blood-brain barrier. key technical

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