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Preparation method of lyxose and application thereof

A technology of lyxose and xylose, which is applied in the field of functional sugar preparation, can solve the problems of complex methods, harsh reaction conditions, and low conversion efficiency, and achieve the effects of simple process, high conversion efficiency, and reduced production investment costs

Active Publication Date: 2014-11-19
SHANDONG FUTASTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above method is relatively complicated, or the reaction conditions are harsh, or the conversion efficiency is low

Method used

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  • Preparation method of lyxose and application thereof
  • Preparation method of lyxose and application thereof
  • Preparation method of lyxose and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1) Preparation of D-lyxose reaction solution

[0034] Weigh 200g of D-xylose, add deionized water to make a 15% solution, add ammonium molybdate according to 1% of the quality of D-xylose, add boric acid according to 0.5% of the quality of D-xylose, stir and dissolve, adjust pH to 3.0, then stirred and heated to 110°C, and reacted for 100 minutes. In the reaction solution, the content of D-lyxose accounts for 41% of the total dry weight. The chromatogram of the reaction solution is shown in figure 1 , Chromatographic conditions: sugar column, pure water as fluidity, column temperature as 75°C, and detector as refractive index detector (with D-xylose and D-lyxose as controls respectively).

[0035] 2) Refining and separation of D-lyxose reaction solution

[0036] D-Lyxose reaction liquid, after adjusting to 75°C, add activated carbon of 2% by weight of dry matter, keep warm and stir for decolorization for 30min; The density is 92%, and the conductivity is 6μs / cm; th...

Embodiment 2

[0038] 1) Preparation of D-lyxose reaction solution

[0039] Weigh 200g of D-xylose, add deionized water to make a 20% solution, add ammonium molybdate according to 0.5% of the quality of D-xylose, add boric acid according to 0.3% of the quality of D-xylose, stir and dissolve, adjust pH to 3.7, then stirred and heated to 100°C, reacted for 120min. In the reaction solution, the content of D-lyxose accounts for 39% of the total dry weight.

[0040] 2) Refining and separation of D-lyxose reaction solution

[0041] D-Lyxose reaction solution, after adjusting to 65°C, add activated carbon of 2% dry matter weight, keep warm and stir for 40min to decolorize; after decarbonization, use D301, 001×7, D301 resin to refine, concentrate to 45°Brix, transmit light The density is 96%, and the conductivity is 11μs / cm; then, the simulated moving bed is used for chromatographic separation to obtain the D-xylose component and the D-lyxose component respectively, and the D-lyxose is concentrate...

Embodiment 3

[0043] 1) Preparation of D-lyxose reaction solution

[0044] Weigh 500g of D-xylose, add deionized water to make a 25% solution, add ammonium molybdate according to 1.5% of the quality of D-xylose, add boric acid according to 1.2% of the quality of D-xylose, stir and dissolve, adjust pH to 3.5, then stirred and heated to 100°C, reacted for 130min. In the reaction solution, the content of D-lyxose accounts for 56% of the total dry weight.

[0045] 2) Refining and separation of D-lyxose reaction solution

[0046] D-Lyxose reaction liquid, after adjusting to 70°C, add activated carbon of 1.5% dry matter weight, keep warm and stir for decolorization for 40min; after decarbonization, use D301, 001×7, D301 resin to refine, concentrate to 45°Brix, transmit light The density is 95%, and the conductivity is 8μs / cm; then, it is chromatographically separated by a simulated moving bed, and the D-xylose component and the D-lyxose component are respectively obtained, and the crystallizati...

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Abstract

The invention provides a preparation method of lyxose. The corresponding structural lyxose is obtained by virtue of catalytic conversion, separation and extraction under the condition of a cocatalyst by taking xylose as a raw material and molybdate as a catalyst. The invention also provides application of the preparation method of the lyxose in preparing D-lyxose. According to the preparation method, the xylose is taken as a reaction substrate, the salt content of reaction liquid is very low, so that the subsequent separation and extraction of the lyxose is facilitated; the reaction liquid is weakly acidic, no strong-corrosive substances exists in a reaction system, so that the requirement for corrosion resistance of an equipment material is not high, and the production investment cost is favorably reduced. The preparation method provided by the invention has the advantages of high conversion efficiency, relative simple process, small investment and low cost.

Description

technical field [0001] The invention relates to the technical field of functional sugar preparation, in particular to a method for preparing lyxose by converting xylose as a raw material and its application. Background technique [0002] D-lyxose is an important pharmaceutical intermediate, which is currently mainly used in the field of biochemistry. It is one of the aldoses in the five-carbon sugar (pentose), and it is an optical isomer with L(+)-lyxose. The currently reported production process is based on the oxidation of calcium-D-galactonate (calcium-D-galactonate) or the conversion of lactose by gamma-ray irradiation. CN201110152249 provides a method for preparing L-lyxose. The technical solution is to use L-arabinose as a raw material, which is reduced to sugar alcohol after hydroxyl protection, and then the molecular configuration is changed under Sven oxidation conditions to finally obtain mirror symmetry. Sexual transformation product L-lyxose. However, the abov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/02C07H1/00
Inventor 邱学良孙鲁秦海青杜瑞锋邵竞峰高永旭周盟盟李毅
Owner SHANDONG FUTASTE