A kind of penicillin compounds chemical screening deduplication method
A compound, penicillin technology, applied in special data processing applications, instruments, electronic digital data processing, etc., can solve the problem of unsatisfactory deduplication and qualitative identification of penicillin compounds, and achieve good results, simple equipment and operation, and fast development time short effect
Inactive Publication Date: 2017-05-24
DALI UNIV
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[0006] The purpose of the present invention is to provide a method for chemical screening and deduplication of penicillin compounds, aiming to solve the problem that the deduplication and qualitative identification of penicillin compounds is not ideal at present
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[0022] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.
[0023] A kind of chemical screening method for penicillin compounds, such as figure 1 shown, including the following steps:
[0024] S1. Under the standardized operating procedure SOP, establish an expanded database of known penicillin compounds, and expand unknown samples under the SOP
[0025] In step S1, the database and SOP are established, as shown in the following table:
[0026] Table 1
[0027]
[0028] According to the content shown in Table 1, the study of known penicillin (β-lactam) compounds is carried out under the standard operating procedure (SOP), R f And its distribution law...
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The invention provides a chemical screening and deduplication method for penicillin compounds. Under the SOP (standard operating procedure), a developed database of known penicillin compounds is established; unknown samples are developed under the SOP; maximum probabilities that the unknown samples contain all know compounds in the presence of developer is calculated; the smallest ones of the maximum probabilities that the unknown samples contain all known compounds under all development conditions is calculated; the smallest ones of the maximum probabilities are compared with a threshold respectively to judge whether or not the unknown samples contain the known compounds. The chemical screening and deduplication method has the advantages such that equipment and operations are simple, cost is the lowest, development time is short, inspection sensitivity is high, multichannel multidimensional detection is performed, offline operations can be discontinuous, derivatization is available, and the results are direct; deduplication qualitative identification is effective.
Description
technical field [0001] The invention belongs to the technical field of separation, screening and deduplication of natural medicines, and in particular relates to a method for chemical screening and deduplication of penicillin compounds. Background technique [0002] At present, the innovation of natural medicine encounters a bottleneck: the repeated discovery rate reaches 99.9%, and deduplication is particularly important. Promising deduplication methods such as LC-MS require expensive instrumentation, are highly specialized, and are often independent of specific natural product isolations. [0003] Thin Layer Chromatography (TLC), also known as thin-layer chromatography, is a micro, fast and simple chromatography, which combines the advantages of column chromatography and paper chromatography, and has the advantages of simple equipment and operation, the lowest cost, It has the advantages of short development time, high detection sensitivity, multi-channel and multi-dimens...
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IPC IPC(8): G06F19/00
Inventor 刘卫红杨建芳宋艳秋刘歆高鹏飞张成桂
Owner DALI UNIV