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Transdermal venous access locking solutions

A solution, growth-inhibiting technology, used in disinfection, coating, chemistry, etc., to solve problems such as lack of anticoagulant characteristics, access obstruction, etc.

Active Publication Date: 2014-11-19
ORGANIC MEDICAL VENTURES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Administering the Stoner's solution into an IV catheter to "lock" the catheter in a quiescent (no flow) state results in rapid occlusion of the access as blood backs up into the device and the composition lacks anticoagulant characteristics

Method used

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  • Transdermal venous access locking solutions
  • Transdermal venous access locking solutions
  • Transdermal venous access locking solutions

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0082] Example 1 Evaluation of Microbial Growth Inhibitory Solutions

[0083] The following studies provide antimicrobial / antifungal testing of formulated microbial growth inhibitory solutions of the present invention.

[0084] Methicillin-resistant Staphylococcus aureus ("MRSA")

[0085] Stock cultures of S. aureus were maintained as frozen stock cultures at -70°C until use. The bacterial test uses Staphylococcus aureus isolated from human blood. Cell suspensions were prepared from frozen stock cultures and grown in Tryptic Soy Broth ("TSB") to obtain approximately 1 x 10 8 MRSA in colony forming units ("CFU"). Use plate counts to confirm the final concentration of the inoculum solution.

[0086] Bacterial Test - For the test, 100 ul of MRSA cell suspension was inoculated into 9.9 ml of each test solution to obtain approximately 1 x 10 6 Final cell concentration of CFU / ml. This represents 1×10 8 1:100 dilution of CFU / ml starter culture; calculate initial cell concent...

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PUM

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Abstract

Microbial growth inhibiting solutions and methods of employing the microbial growth inhibiting solutions in flushing and coating medical devices are disclosed. In alternative embodiments, the microbial growth inhibiting solutions include combinations of a chelating agent with a C4-C9 carboxylate antimicrobial agent, for example, such as n-octanoic acid. Methods of using these microbial growth inhibiting solutions for coating a medical device and for inhibiting catheter infection are also disclosed.

Description

technical field [0001] The present invention relates to the field of transdermal indwelling medical devices, such as catheters, and the field of microbial growth inhibiting solutions for flushing, locking and coating these medical devices. More specifically, the field of the invention relates to microbial growth inhibiting solutions. The present invention also relates to microbial growth inhibiting solutions useful for maintaining catheter patency and preventing infection. The present invention also relates to methods of managing and maintaining transdermal vascular access catheters using the microbial growth inhibiting solutions of the present invention. Background technique [0002] Transdermal medical devices, including vascular catheters, have become essential in managing hospitalized or chronically ill patients. Unfortunately, vascular catheters have become a major source of hospital-acquired sepsis. Thus, infectious complications often undermine the benefits derived...

Claims

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Application Information

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IPC IPC(8): A01N31/02A61L2/18A61L29/08A61L29/16
CPCA61L2/18A01N37/02A61L2/0088A61L2202/24A61L2/232A01N2300/00A01N37/44A01N31/02A61L29/08A61L29/16
Inventor 斯坦利·L·米尔斯杰奎琳·L·米尔斯罗伯特·D·莫勒加里·L·雷伯恩马文·A·库臣斯
Owner ORGANIC MEDICAL VENTURES
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