A kind of medicine balloon and preparation method thereof

A technology of balloons and drugs, which is applied in the field of medical devices and can solve problems in the field of drug balloons that have not yet been discovered

Active Publication Date: 2017-06-27
SHANGHAI VASOLUTIONS MEDTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The targeted drug delivery preparation made by using this characteristic of the magnetic field is a magnetic preparation, which has been used to some extent, but it has not been found to be used in the field of drug balloons.

Method used

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  • A kind of medicine balloon and preparation method thereof
  • A kind of medicine balloon and preparation method thereof
  • A kind of medicine balloon and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0028] 1. Preparation of Magnetic Balloons

[0029] The magnetic sleeve on the outside of the inner tube of the balloon is made of cobalt-chromium alloy material, which is magnetized by an external magnetic field and nested on the surface of the inner tube of the balloon to form a magnetic balloon.

[0030] 2. Preparation of Paclitaxel-loaded Magnetic Microparticle Suspension

[0031] FeSO 4 and FeCl 3 The mixed solution (molar ratio 1:1.75) was added dropwise to ammonia water at pH 10 for co-precipitation reaction. High concentration of ammonia water was used to maintain the pH value of the system, and ultrasonic treatment was applied during the reaction. After the iron salt mixture is added dropwise (iron ion concentration is about 1mol / l), mature in a constant temperature water bath at 60°C for 30 minutes, and wash with deionized water until there is no Cl - and SO 4 2- . Ultrasonic treatment was applied during the cleaning process, followed by washing with absolute...

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Abstract

The invention belongs to the field of medical devices, and in particular relates to a drug balloon and a preparation method thereof. The drug balloon of the present invention is characterized in that: the inner tube of the balloon has a permanent magnetic material, and the drug exists on the surface of the balloon in the form of drug-loaded magnetic particles to form a drug coating based on a magnetic trigger mechanism. The drug coating of the invention can not only ensure the least drug loss during the delivery process of the balloon, but also ensure sufficient, rapid and efficient release and absorption of the drug in the diseased part.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a drug balloon and a preparation method thereof. Background technique [0002] Vascular stenosis is the main cause of morbidity and death, and the common method for treating vascular stenosis is interventional therapy. At present, the success rate of bare metal stents in angioplasty is over 95%, and the vascular endothelial cells can heal automatically within 30 days, and patients do not need to take anticoagulant drugs. However, 25%-50% of patients will have restenosis 3-6 months after surgery, which limits the long-term efficacy of coronary interventional therapy (PCI). [0003] With the wide application of drug sustained-release stent systems and the continuous development of new technologies, the research on drug sustained-release stents has become more in-depth. Drugs (such as rapamycin and its derivatives, paclitaxel and its derivatives) sustained-release stents...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M25/10A61L31/08A61L31/16A61L31/14
Inventor 张鹏张琳琳郭芳段志邦丁璇李中华罗七一
Owner SHANGHAI VASOLUTIONS MEDTECH CO LTD
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