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The present invention relates to a composition comprising vesicles released from activated T lymphocytes, and methods for its production and application. The vesicles contain a series of biologically active molecules that confer upon them notable properties such as: antigen recognition, antigen presentation, and other regulatory and effector functions. The present invention also relates to the transfer or delivery of antigenic molecules (such as peptides, peptide / MHC complexes, TCR and its subunits, etc.) using the above-mentioned vesicles to antigen-presenting cells (APCs) to induce specific immune responses, especially specific CTLs method of answering. The present invention also relates to methods for selectively or specifically delivering molecules to target cells using the above-mentioned vesicles.

The invention belongs to the field of pharmacy, and particularly relates to a pharmaceutic preparation of palbociclib and a preparation method of the pharmaceutic preparation. The pharmaceutic preparation comprises the palbociclib, acidic auxiliary materials and an optional hydrophilic high polymer material. Compared with a conventional preparation, the pharmaceutic preparation of the palbociclibhas excellent solubility and an in-vitro dissolution property, and can be used for enhancing in-vivo absorption and bioavailability of the palbociclib.

The invention provides a film-laminating thickness control system, a film laminating machine comprising the same, and a film-laminating thickness control method. The film-laminating thickness control system comprises a shell, a light-emitting diode array, middle support parts and a photosensitive device array, wherein the light-emitting diode array, the middle support parts and the photosensitive device array are assembled in the shell in sequence; the light-emitting diode array is used for emitting light; the middle support parts comprise an upper through hole array, a lower through hole array, a slot and a control circuit; the upper through hole array and the lower through hole array correspond to the light-emitting diode array; the slot is formed between and communicated with the upper through hole array and the lower through hole array; a film passes through the slot; the light-emitting diode array is assembled in the upper through hole array; the photosensitive device array is assembled in the lower through hole array and used for converting received light to terminal voltage; the control circuit is used for comparing a standard voltage with terminal voltage of the photosensitive device array and controlling a stepping motor for feeding the film based on a comparison result to obtain suitable film thickness. The film-laminating thickness control system is capable of judging whether the thickness of a polymer film is suitable when the film is fed by the film laminating machine in real time and correspondingly controlling the stepping motor based on a judgment result so as to adjust the thickness of the film to be suitable.

The invention relates to a polyether / aminopolysiloxane block copolymer and use thereof. The polyether / aminopolysiloxane block copolymer is prepared mainly by reacting a compound shown in a formula I with a compound shown in a formula II at 50 to 90 DEG C, and has the viscosity of 2,000 mPa.S to 7,500 mPa.S at 25 DEG C. The block copolymer can be used as a textile softening finishing agent. In the formulae I and II, R1 is H, C1 to C6 are linear or branched chain alkyls or hydroxyls, a is an integer from 0 to 20, m is 4 to 13, and n is 12 to 25.

The invention provides a method and a device for monitoring infusion of an insulin pen. The method integrates first detecting, second detecting and third detecting. The first detecting is used for detecting whether an infusion requirement unit is finished. The second detecting is used for detecting whether the infusion is unfinished in a timing mode or whether a motor continues infusion after normal time required by infusion. The third detecting is used for detecting whether motor and control data faults occur in real time in an infusion process. As long as any detecting is effectively, conditions requiring closing or stopping infusion can be detected timely, and the infusion can be closed or stopped timely so that infusion risks can be prevented better. In addition, implementation price of the monitoring method is low, and the method is easy to achieve and can be applied to various insulin pens in the market flexibly.

The invention discloses a catalytic conversion technology for carbon tetrachloride. The technology is implemented in an autoclave. The technology is characterized in that: a catalyst comprises Ag, AgCl or composition thereof serving as active ingredients; a catalyst carrier comprises silicon dioxide, titanium dioxide, active carbon or mesoporous carbon or composition thereof; and under the action of the catalyst, aids are added into a mixture of carbon tetrachloride and methanol, and a part of carbon tetrachloride is converted into dichloromethane. By the method, the conversion rate of carbon tetrachloride can be improved, the reaction time is shortened, and the selectivity of dichloromethane is improved.

The invention relates to an amino modified polysiloxane copolymer with a modified group amino on a polysiloxane copolymer backbone and a application thereof. The amino modified polysiloxane copolymer comprises a polyamine chain segment, a polyether chain segment and a polysiloxane chain segment, wherein the viscosity of the amino modified polysiloxane copolymer is 38, 591-10, 272 cp (25 DEG C). The amino modified polysiloxane copolymer provided by the invention can be used as organic pigment (in particular heterocyclic or azo organic pigments) dispersants.

The invention belongs to the field of medical devices, and in particular relates to a drug balloon and a preparation method thereof. The drug balloon of the present invention is characterized in that: the inner tube of the balloon has a permanent magnetic material, and the drug exists on the surface of the balloon in the form of drug-loaded magnetic particles to form a drug coating based on a magnetic trigger mechanism. The drug coating of the invention can not only ensure the least drug loss during the delivery process of the balloon, but also ensure sufficient, rapid and efficient release and absorption of the drug in the diseased part.

The invention belongs to the field of pharmacy, and in particular relates to a pharmaceutical preparation of palbociclib and a preparation method thereof. The pharmaceutical preparation includes palbociclib, acidic excipients and optional hydrophilic polymer materials, which have better solubility and in vitro dissolution properties than conventional preparations, and can be used to enhance the in vivo absorption and absorption of palbociclib. bioavailability.