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Double-side coated drug eluting stent containing magnetic bottom layer and manufacturing method thereof

A technology for eluting stents and active drugs, applied in the field of medical devices, can solve the problems of limited adsorption capacity of magnetic nanoparticles, limited magnetic response ability, and no practical application of magnetic nanoparticles, and achieve the effect of dual-target release

Active Publication Date: 2014-02-12
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, magnetic nanoparticles have no practical application in drug-eluting stents at present, and magnetic nanoparticles provide a solution for the differentiation and functional design of the inner and outer surface coatings of drug stents
[0006] In addition, the metal stents of existing market products are mainly made of stainless steel and cobalt-chromium alloy. These materials have limited magnetic response to external magnetic fields and limited adsorption capacity for magnetic nanoparticles, which limits the use of magnetic nanoparticles on existing metal stent platforms. applications on, but the electrodeposition method offers the technical feasibility of

Method used

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  • Double-side coated drug eluting stent containing magnetic bottom layer and manufacturing method thereof
  • Double-side coated drug eluting stent containing magnetic bottom layer and manufacturing method thereof
  • Double-side coated drug eluting stent containing magnetic bottom layer and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) The stent is made of stainless steel, and a metal stent is prepared by laser cutting technology for use.

[0048] (2) depositing a layer of Co / Ni hard magnetic bottom layer on the inner and outer surfaces of the above-mentioned metal support by an electrodeposition method. The process includes: preparing a composition containing 0.2M NiCl 2 , (0.1-0.206) M CoCl 2 , 0.4M H 3 BO 3 , 0.7M NaCl, and (0.0097-0.0485) M saccharin (Sigma, MO) in 100 ml of electrodeposition solution, pH 3-4, press figure 2 The electrodeposition process was performed as shown, resulting in a metal scaffold with a magnetic underlayer.

[0049] (3) Take 0.1g of poly-D,L-lactic acid (PDLLA, the weight average molecular weight range is 30,000-140,000), add it to 10ml of n-propyl acetate to dissolve at room temperature, prepare a uniform solution, and then add 0.1g of rapamycin The ingredients are mixed evenly, the prepared solution is accurately sprayed onto the outer surface of the above-me...

Embodiment 2

[0056] (1) The stent is made of stainless steel, and a bare metal stent is prepared by laser cutting technology for use.

[0057] (2) depositing a layer of Co / Ni / P hard magnetic bottom layer on the inner and outer surfaces of the above-mentioned metal support by an electrodeposition method, the process includes: preparing a composition containing 0.2M NiCl 2 , (0.1-0.206) M CoCl 2 , (0.047-0.566)M NaH 2 PO 2 , 0.4M H 3 BO 3 , 0.7M NaCl, and (0.0097-0.0485) M saccharin (Sigma, MO) in 100 ml of electrodeposition solution, pH 3-4, press figure 2 The electrodeposition process was performed as shown, resulting in a metal scaffold with a magnetic underlayer.

[0058] (3) Take 0.1g of poly-D,L-lactic acid (PDLLA, the weight average molecular weight range is 30,000-140,000), add it to 10ml of n-propyl acetate to dissolve at room temperature, prepare a uniform solution, and then add 0.1g of rapamycin Mix the ingredients evenly, spray the prepared solution on the outer surface of...

Embodiment 3

[0066] (1) The stent is made of stainless steel, and a bare metal stent is prepared by laser cutting technology for use.

[0067] (2) A layer of Co / Ni soft magnetic bottom layer is deposited on the inner and outer surfaces of the above-mentioned metal support by an electrodeposition method, and the process includes: preparing a composition containing 0.45M NiCl 2 , 0.65M CoCl 2 , 30g / dm -3 H 3 BO 3 and trace amount of saccharin (Sigma, MO) in 100 ml of electrodeposition solution, press figure 2 The electrodeposition process was performed as shown, resulting in a metal scaffold with a magnetic underlayer.

[0068] (3) Take 0.1g of poly-D,L-lactic acid (PDLLA, the weight average molecular weight range is 30,000-140,000), add it to 10ml of n-propyl acetate to dissolve at room temperature, prepare a uniform solution, and then add 0.1g of rapamycin Mix the ingredients evenly, spray the prepared solution on the outer surface of the stent accurately, place the stent in a vacuum...

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PUM

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Abstract

The invention belongs to the field of medical instruments, and particularly relates to a drug eluting stent. The drug eluting stent comprises a stent body, a stent magnetic bottom layer, a stent outer surface coating and a stent inner surface coating, wherein the stent outer surface coating comprises a biodegradable polymer and an active medicament; the stent inner surface coating comprises magnetic nanoparticles and an active medicament. The drug eluting stent realizes the design of different functional medicinal coatings on the inner and outer surfaces of the stent and further realizes double-target release of different functional medicaments.

Description

technical field [0001] The invention belongs to the field of medical devices, and particularly relates to a double-sided double-drug coating drug-eluting stent containing a magnetic bottom layer, which can reduce in-stent restenosis, the incidence of late vascular thrombosis and improve stent endothelialization. Background technique [0002] In recent years, drug-eluting stents have been widely used in the treatment of coronary heart disease. Compared with bare metal stents, a large number of clinical results show that drug-eluting stents can effectively inhibit the proliferation of smooth muscle, significantly reduce the rate of stent restenosis and target vessel revascularization, and can reduce the restenosis rate to 10% or even lower. s level. [0003] Most of the existing drug-eluting stent products are coated with drugs on the inner and outer surfaces, the concentration of drugs in the blood vessels is large, and the release direction cannot be effectively controlled,...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61L31/10A61L31/08A61L31/14A61L31/16C25D7/00A61M31/00
Inventor 周奇姚瑶李俊菲唐智荣罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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