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Medicine balloon and preparation method thereof

A balloon and drug technology, applied in the field of medical devices, can solve problems in the field of drug balloons that have not yet been found

Active Publication Date: 2014-12-03
SHANGHAI VASOLUTIONS MEDTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The targeted drug delivery preparation made by using this characteristic of the magnetic field is a magnetic preparation, which has been used to some extent, but it has not been found to be used in the field of drug balloons.

Method used

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  • Medicine balloon and preparation method thereof
  • Medicine balloon and preparation method thereof
  • Medicine balloon and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0028] 1. Preparation of Magnetic Balloons

[0029] The magnetic sleeve on the outside of the inner tube of the balloon is made of cobalt-chromium alloy material, which is magnetized by an external magnetic field and nested on the surface of the inner tube of the balloon to form a magnetic balloon.

[0030] 2. Preparation of Paclitaxel-loaded Magnetic Microparticle Suspension

[0031] FeSO 4 and FeCl 3 The mixed solution (molar ratio 1:1.75) was added dropwise to ammonia water at pH 10 for co-precipitation reaction. High concentration of ammonia water was used to maintain the pH value of the system, and ultrasonic treatment was applied during the reaction. After the iron salt mixture is added dropwise (iron ion concentration is about 1mol / l), mature in a constant temperature water bath at 60°C for 30 minutes, and wash with deionized water until there is no Cl - and SO 4 2- . Ultrasonic treatment was applied during the cleaning process, followed by washing with absolute...

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Abstract

The invention belongs to the field of medical equipment, and particularly relates to a medicine balloon and a preparation method of the medicine balloon. The medicine balloon is characterized in that permanent magnetic material is arranged in an inner tube of the balloon; medicine exists on the surface of the balloon in a form of medicine-load magnetic particles, so that a medicine coating based on a magnetic triggering mechanism is formed. According to the medicine balloon, the medicine coating is arranged, so that the medicine loss is enabled to be reduced as far as possible in a balloon conveying process, and the medicine is enabled to be sufficiently, rapidly and efficiently released and absorbed at a diseased region.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a drug balloon and a preparation method thereof. Background technique [0002] Vascular stenosis is the main cause of morbidity and death, and the common method for treating vascular stenosis is interventional therapy. At present, the success rate of bare metal stents in angioplasty is over 95%, and the vascular endothelial cells can heal automatically within 30 days, and patients do not need to take anticoagulant drugs. However, 25%-50% of patients will have restenosis 3-6 months after surgery, which limits the long-term efficacy of coronary interventional therapy (PCI). [0003] With the wide application of drug sustained-release stent systems and the continuous development of new technologies, the research on drug sustained-release stents has become more in-depth. Drugs (such as rapamycin and its derivatives, paclitaxel and its derivatives) sustained-release stents...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/10A61L31/08A61L31/16A61L31/14
Inventor 张鹏张琳琳郭芳段志邦丁璇李中华罗七一
Owner SHANGHAI VASOLUTIONS MEDTECH CO LTD
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