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A double-sided coated drug-eluting stent containing a magnetic bottom layer and its manufacturing method

A technology for eluting stents and active drugs, applied in the field of medical devices, can solve the problems of limited adsorption capacity of magnetic nanoparticles, no practical application of magnetic nanoparticles, limited magnetic response ability, etc., and achieve the effect of dual-target release

Active Publication Date: 2017-02-22
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, magnetic nanoparticles have no practical application in drug-eluting stents at present, and magnetic nanoparticles provide a solution for the differentiation and functional design of the inner and outer surface coatings of drug stents
[0006] In addition, the metal stents of existing market products are mainly made of stainless steel and cobalt-chromium alloy. These materials have limited magnetic response to external magnetic fields and limited adsorption capacity for magnetic nanoparticles, which limits the use of magnetic nanoparticles on existing metal stent platforms. applications on, but the electrodeposition method offers the technical feasibility of

Method used

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  • A double-sided coated drug-eluting stent containing a magnetic bottom layer and its manufacturing method
  • A double-sided coated drug-eluting stent containing a magnetic bottom layer and its manufacturing method
  • A double-sided coated drug-eluting stent containing a magnetic bottom layer and its manufacturing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) The material of the bracket is stainless steel, and the metal bracket is prepared by laser cutting technology for use.

[0048] (2) Electrodeposition is used to deposit a layer of Co / Ni hard magnetic bottom layer on the inner and outer surfaces of the above-mentioned metal support. The process includes: preparing 0.2M NiCl 2 , (0.1-0.206) M CoCl 2 , 0.4M H 3 BO 3 , 0.7M NaCl, and (0.0097-0.0485) M saccharin (Sigma, MO) 100 ml electrodeposition solution, pH 3-4, press figure 2 The electrodeposition process was carried out as shown to obtain a metal stent with a magnetic underlayer.

[0049] (3) Take 0.1g poly D,L-lactic acid (PDLLA, weight average molecular weight range is 30,000-140,000), dissolve it in 10ml n-propyl acetate at room temperature, prepare a uniform solution, and then add 0.1g rapamycin Mix the ingredients evenly, accurately spray the prepared solution onto the outer surface of the stent containing the magnetic bottom layer, dry the stent in a vac...

Embodiment 2

[0056] (1) The stent is made of stainless steel, and the bare metal stent is prepared by laser cutting technology for use.

[0057] (2) Deposit a layer of Co / Ni / P hard magnetic bottom layer on the inner and outer surfaces of the above-mentioned metal bracket by electrodeposition method, and the process includes: preparing a 0.2M NiCl 2 , (0.1-0.206) M CoCl 2 , (0.047-0.566) M NaH 2 PO 2 , 0.4M H 3 BO 3 , 0.7M NaCl, and (0.0097-0.0485) M saccharin (Sigma, MO) 100 ml electrodeposition solution, pH 3-4, press figure 2 The electrodeposition process was carried out as shown to obtain a metal stent with a magnetic underlayer.

[0058] (3) Take 0.1g poly D,L-lactic acid (PDLLA, weight average molecular weight range is 30,000-140,000), dissolve it in 10ml n-propyl acetate at room temperature, prepare a uniform solution, and then add 0.1g rapamycin The ingredients were mixed evenly, and the prepared solution was accurately sprayed onto the outer surface of the stent, and the ste...

Embodiment 3

[0066] (1) The stent is made of stainless steel, and the bare metal stent is prepared by laser cutting technology for use.

[0067] (2) Deposit a layer of Co / Ni soft magnetic bottom layer on the inner and outer surfaces of the above-mentioned metal bracket by electrodeposition method, and the process includes: preparing 0.45M NiCl 2 , 0.65M CoCl 2 、30g / dm -3 h 3 BO 3 and trace saccharin (Sigma, MO) of 100 ml electrodeposition solution, press figure 2 The electrodeposition process was carried out as shown to obtain a metal stent with a magnetic underlayer.

[0068] (3) Take 0.1g poly D,L-lactic acid (PDLLA, weight average molecular weight range is 30,000-140,000), dissolve it in 10ml n-propyl acetate at room temperature, prepare a uniform solution, and then add 0.1g rapamycin The ingredients were mixed evenly, and the prepared solution was accurately sprayed onto the outer surface of the stent, and the stent was dried in a vacuum oven, and sterilized by ethylene oxide for...

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Abstract

The invention belongs to the field of medical instruments, and particularly relates to a drug eluting stent. The drug eluting stent comprises a stent body, a stent magnetic bottom layer, a stent outer surface coating and a stent inner surface coating, wherein the stent outer surface coating comprises a biodegradable polymer and an active medicament; the stent inner surface coating comprises magnetic nanoparticles and an active medicament. The drug eluting stent realizes the design of different functional medicinal coatings on the inner and outer surfaces of the stent and further realizes double-target release of different functional medicaments.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a drug-eluting stent with a magnetic bottom layer and a double-sided double-drug coating that can reduce restenosis in a stent and the incidence of late vessel thrombosis and improve endothelialization of the stent. Background technique [0002] In recent years, drug-eluting stents have been widely used in the treatment of coronary heart disease. Compared with bare metal stents, a large number of clinical results show that drug-eluting stents can effectively inhibit the proliferation of smooth muscle, significantly reduce the rate of stent restenosis and target vessel revascularization, and can reduce the restenosis rate to 10% or even lower s level. [0003] Most of the existing drug-eluting stent products are coated with drugs on the inner and outer surfaces, the drug concentration in the blood vessel is relatively high, and the release direction cannot be effectivel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/82A61L31/10A61L31/08A61L31/14A61L31/16C25D7/00A61M31/00
Inventor 周奇姚瑶李俊菲唐智荣罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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