Composition for improving sleep, and preparation method and application thereof

A technology for improving sleep and composition, applied in the field of composition and preparation for improving sleep, can solve the problems of toxic and side effects, unsuitable for long-term use, easy to produce dependence, etc., achieves strong biological activity, is beneficial to human body absorption, and increases biological utilization. degree of effect

Active Publication Date: 2014-12-24
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current clinical treatment for sleep disorders is mainly to take sedative and hypnotic drugs, such as benzodiazepines, barbiturates, sedatives,...

Method used

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  • Composition for improving sleep, and preparation method and application thereof
  • Composition for improving sleep, and preparation method and application thereof
  • Composition for improving sleep, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A composition for improving sleep, the active ingredients of which are prepared from the following raw materials:

[0047] Cordyceps militaris 500g, cistanche 500g, licorice 500g, jujube 1000g, wheat 5000g, bellflower 500g.

[0048] The specific preparation method is as follows:

[0049] (1) Preparation of extract one

[0050] Weigh 500g of Cordyceps militaris, wash and dry at 60°C for 4 hours; pulverize at room temperature and pass through an 80-mesh sieve to obtain coarse powder of Cordyceps militaris; add pure water 10 times the weight of the raw material of Cordyceps militaris, soak at room temperature After 1 hour, use 0.1mol / L hydrochloric acid to adjust the pH to 2.0; then add 0.5% pepsin by weight of the raw material of Cordyceps militaris and trypsin with 0.5% by weight of the raw material of Cordyceps militaris, and perform enzymatic hydrolysis at 37°C for 5 hours Afterwards, heat to 100°C to inactivate the enzyme for 20 minutes, filter to obtain an enzymati...

Embodiment 2

[0055] A composition for improving sleep, the active ingredients of which are prepared from the following raw materials:

[0056] Cordyceps militaris 500g, Cistanche 100g, licorice 500g, jujube 200g, wheat 3000g, bellflower 100g.

[0057] The specific preparation method is as follows:

[0058] (1) Preparation of extract one

[0059] Weigh 500g of Cordyceps militaris, wash and dry at 50°C for 5 hours; pulverize at room temperature and pass through an 80-mesh sieve to obtain coarse powder of Cordyceps militaris; After 1 hour, adjust the pH to 1.0 with 0.1 mol / L hydrochloric acid; then add 0.2% pepsin and 0.4% trypsin by weight of the raw material of Cordyceps militaris respectively, and perform enzymolysis at 37°C for 8 hours Afterwards, heat to 100°C to inactivate the enzyme for 15 minutes, filter to obtain an enzymatic hydrolysis solution, and filter the enzymolysis solution through an ultrafiltration column with a molecular weight cut-off of 100,000 to obtain a filtrate of ...

Embodiment 3

[0064] A composition for improving sleep, the active ingredients of which are prepared from the following raw materials:

[0065] Cordyceps militaris 100g, cistanche 500g, licorice 100g, jujube 1000g, wheat 1000g, bellflower 500g.

[0066] The specific preparation method is as follows:

[0067] (1) Preparation of extract one

[0068] Weigh 100g of Cordyceps militaris, wash and dry at 40°C for 6 hours; pulverize at room temperature and pass through an 80-mesh sieve to obtain coarse powder of Cordyceps militaris; add pure water 15 times the weight of the raw material of Cordyceps militaris, soak at room temperature for 3 After 1 hour, adjust the pH to 3.0 with 0.1 mol / L hydrochloric acid; then add 0.8% pepsin by weight of the raw material of Cordyceps militaris and trypsin with 0.4% by weight of the raw material of Cordyceps militaris, and perform enzymatic hydrolysis at 37°C for 2 hours Afterwards, heat to 100°C to inactivate the enzyme for 30 minutes, filter to obtain an enz...

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Abstract

The invention discloses a composition for improving sleep, and a preparation method and application thereof, belonging to the technical field of medicines. The composition disclosed by the invention is prepared from the following raw materials in parts by weight: 1-5 parts of cordyceps militaris, 1-5 parts of cistanche, 1-5 parts of liquorice, 2-10 parts of Chinese date, 10-30 parts of wheat and 1-5 parts of platycodon grandiflorum. The preparation method disclosed by the invention comprises the following steps of: extracting active ingredients from cordyceps militaris through a composite biological enzymolysis and ultrafiltration technology and preparing first extract; carrying out reflux extraction on cistanche and liquorice by using 40-80% ethanol solution to prepare second extract; extracting Chinese data, wheat and platycodon grandiflorum by using water at 80-100 DEG C, to obtain third extract; and uniformly mixing the first extract, the second extract and the third extract, thus obtaining the composition for improving sleep. The composition disclosed by the invention has the effect of improving sleep; furthermore, all the raw materials are food materials or medicinal and edible dual-purpose medicines, so that the composition accords with the principle of homology of medicines and foods; and thus, the composition disclosed by the invention is natural and hardly causes toxic or side effect and is suitable for being taken for a long time.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition for improving sleep, a preparation method and application thereof. Background technique [0002] Sleep is closely related to people's health. Sleep disorders refer to abnormal sleep volume and abnormal behavior during sleep. Sleep disturbances can be multifactorial and often disease-related, including sleep disorders and parasomnias. Surveys show that many people suffer from sleep disorders or sleep-related diseases, and the proportion of adults with sleep disorders is as high as 30%. Sleep is an extremely important physiological function to maintain human life, and it is essential to the human body. Therefore, sleep disorders must be given enough attention. Long-term insomnia can lead to brain dysfunction, cause various harms to the body, and seriously affect physical and mental health [0003] The current clinical treatment for sleep disorders is mainly to ta...

Claims

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Application Information

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IPC IPC(8): A61K36/899A23L1/29A61P25/20A61P39/06A61P37/04A23L33/00
Inventor 苑广信杜培革安丽萍赵南晰李洪宇徐广宇盛瑜王曼力孙晶波韩笑邵晓彤宋丹丹
Owner BEIHUA UNIV
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