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A preparation method of wound antibacterial milk containing hexagonal mesoporous silicon

A technology of hexagonal mesoporous silicon and antibacterial milk, which is applied to medical preparations containing active ingredients, local antibacterial agents, and medical preparations with no active ingredients, etc., can solve the problem of keeping the wound skin clean and sterile, and the long-term Effective broad-spectrum antibacterial and antibacterial effects, etc., to achieve the effect of good touch, strong broad-spectrum antibacterial and antibacterial effect, and simple equipment

Active Publication Date: 2016-09-21
广州智园生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since alcohol and iodine disinfectants do not have the function of penetrating and killing bacteria and microorganisms, the use of conventional alcohol and iodine disinfectants is far from achieving the long-term broad-spectrum sterilization and antibacterial effect, and it is difficult to keep the wound skin clean and sterile
[0004] So far, there is no report on the use of hexagonal mesoporous silicon as a slow and controlled release antibacterial milk

Method used

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  • A preparation method of wound antibacterial milk containing hexagonal mesoporous silicon
  • A preparation method of wound antibacterial milk containing hexagonal mesoporous silicon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Preparation of hexagonal mesoporous silica loaded chlorhexidine acetate:

[0025] Weigh 2g of chlorhexidine acetate, dissolve it in 1000ml of absolute ethanol and put it in a sealed glass bottle, add 1g of hexagonal mesoporous silicon, put it in a shaker at 32°C for 6h, then wash it with deionized water for 3 times and centrifuge , and finally put the obtained precipitate in an oven at 50° C. for 24 hours, and put the final product in a desiccator for use.

[0026] (2) Preparation of nano-silver antibacterial agent microemulsion:

[0027] Dissolve 100 μg of nano-silver antibacterial agent in 25 g of absolute ethanol, then add 25 g of Tween-80, 5 g of isopropyl palmitate, mix and slowly stir for 3 min, then add deionized water drop by drop until the total mass of the microemulsion is 100 g, drop After the addition was completed, the mixed solution was stirred for 8 hours to obtain a microemulsion containing nano-silver antibacterial agent.

[0028] (3) Compounding ...

Embodiment 2

[0031] (1) Preparation of hexagonal mesoporous silica loaded chlorhexidine acetate:

[0032] Weigh 3.5g of chlorhexidine acetate, dissolve it in 1000ml of absolute ethanol and put it in a sealed glass bottle, add 1.4g of hexagonal mesoporous silicon, put it in a shaker at 35°C for 8h, and then wash it with deionized water for 3 times After centrifugation, the resulting precipitate was placed in an oven at 70°C for 36 hours, and the final product was placed in a desiccator for use.

[0033] (2) Preparation of nano-silver antibacterial agent microemulsion:

[0034] Dissolve 150 μg of nano-silver antibacterial agent in 30 g of absolute ethanol, then add 30 g of Tween-80, 5 g of isopropyl palmitate, mix and slowly stir for 5 min, then add deionized water drop by drop until the total mass of the microemulsion is 100 g, drop After the addition was completed, the mixed solution was stirred for 12 hours to obtain a microemulsion containing nano-silver antibacterial agent.

[0035] (...

Embodiment 3

[0038] (1) Preparation of hexagonal mesoporous silica loaded chlorhexidine acetate:

[0039] Weigh 3g of chlorhexidine acetate, dissolve it in 1000ml of absolute ethanol and put it in a sealed glass bottle, add 1g of hexagonal mesoporous silicon, put it in a shaker at 35°C for 8h, wash it with deionized water for 3 times and centrifuge , and finally put the obtained precipitate in an oven at 60° C. for 48 hours, and put the final product in a desiccator for use.

[0040] (2) Preparation of nano-silver antibacterial agent microemulsion:

[0041] Dissolve 150 μg of nano-silver antibacterial agent in 20 g of absolute ethanol, then add 20 g of Tween-80, 5 g of isopropyl palmitate, mix and slowly stir for 5 min, then add deionized water drop by drop until the total mass of the microemulsion is 100 g, drop After the addition was completed, the mixed solution was stirred for 10 hours to obtain a microemulsion containing nano-silver antibacterial agent.

[0042] (3) Compounding of h...

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Abstract

The invention discloses a preparation method of wound antibacterial milk containing hexagonal mesoporous silicon. The method comprises the steps of preparing hexagonal mesoporous silicon-loaded chlorhexidine acetate, preparing microemulsions containing nano-silver antibacterial agents, and adding a pH regulator for compounding. The invention contains a variety of antibacterial ingredients, which have strong broad-spectrum bactericidal and antibacterial effects. At the same time, the structural characteristics of mesoporous silicon can be used to improve the stability and slow release of the loaded antibacterial active ingredients. The antibacterial milk has a long-acting antibacterial effect. In addition, mesoporous silicon can also improve the adhesion of the emulsion, make the touch feel good, have no irritation to the skin, and have no side effects.

Description

technical field [0001] The invention belongs to the field of sterilization, and in particular relates to a preparation method of wound antibacterial milk containing hexagonal mesoporous silicon. Background technique [0002] The skin is the outermost layer of our body and is the largest organ in the body. It is both an effector and a sensory organ of the nervous system. Skin covers the whole body and is the first barrier of the human body, protecting various tissues and organs in the body from mechanical, physical, chemical and pathogenic microorganisms. Therefore, when the skin is damaged, it is easy to cause microbial infection, and then cause various complications, which are harmful to health. Therefore, the sterilization of skin wounds is very important. [0003] Alcohol and iodine disinfectants are generally used in hospitals to disinfect and sterilize wounds. Because these two substances can only eliminate a part of bacteria or viruses, and the effect is not sustai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/04A61K33/38A61K9/107A61P31/02A61K31/155
Inventor 魏坤冯海湾
Owner 广州智园生物科技有限公司
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