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Construction of controlled-release TrkC receptor ligand gelatin sponge cylinder bracket for repairing spinal cord injury

A gelatin sponge, spinal cord injury technology, applied in prosthesis, medical science and other directions, can solve the problems of limited application of neurotrophic factors, unsatisfactory clinical effect, etc., to promote social and economic development, prolong human lifespan, reduce social and family burden effect

Inactive Publication Date: 2015-01-07
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that because exogenous drug delivery methods cannot meet the requirements in the process of spinal cord nerve regeneration, the clinical effect of traditional drug delivery routes such as injection of neurotrophic factors is not satisfactory, which limits the wide application of neurotrophic factors.

Method used

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  • Construction of controlled-release TrkC receptor ligand gelatin sponge cylinder bracket for repairing spinal cord injury
  • Construction of controlled-release TrkC receptor ligand gelatin sponge cylinder bracket for repairing spinal cord injury
  • Construction of controlled-release TrkC receptor ligand gelatin sponge cylinder bracket for repairing spinal cord injury

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Experimental program
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Effect test

Embodiment Construction

[0014] The main instruments used in the present invention, degradable natural biological materials, degradable polymer synthetic materials, silkworm cocoons, neurotrophic factors, experimental cells, experimental animals and reagents are described in detail below by specific examples:

[0015] 1. Main instruments

[0016] Ultra-clean workbench (Suzhou Purification Equipment Co., Ltd.), ordinary centrifuge (Japan Kubota Manufacturing Co., Ltd.), low-temperature high-speed centrifuge (US Eppendorf Company), 5% CO 2 Incubator (U.S. Queue Company), inverted fluorescence microscope (Germany Leica Company), enzyme-linked immunoassay instrument (U.S. Bio-Rad Company), thermostat slicer (U.K. Shandon Company) and XL30FEG scanning electron microscope (Germany Philips Company) .

[0017] 2. Degradable natural biomaterials

[0018] Gelatin sponge was purchased from Nanjing Jinling Pharmaceutical Co., Ltd.

[0019] 3. Degradable polymer synthetic materials

[0020] PLGA (50:50) films ...

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Abstract

The invention relates to a construction method of a controlled-release TrkC receptor ligand-NT-3 (neurotrophin-3) gelatin sponge cylinder bracket for repairing the spinal cord injury, particularly to a construction method of a controlled-release TrkC receptor ligand gelatin sponge bracket material containing overexpression TrkC receptor cells. During application, the controlled-release TrkC receptor ligand gelatin sponge cylinder bracket with the overexpression TrkC receptor cells and differentiated cells of the overexpression TrkC receptor cells implanted is transplanted to a cross-sectional spinal cord injury position and can better promote regeneration and function repair of injured nervous centralis. The construction method has great significance in enhancement of protection of injured nerve cells after the cross-sectional spinal cord injury at the biological tissue engineering level, promotion of axonal regeneration of the nerve cells, improvement on the quality of life of the sick and the injured, reduction of social and family burdens and promotion of social and economic development in China.

Description

technical field [0001] The invention relates to a method for constructing a slow-release TrkC receptor ligand-neurotrophin-3 (neurotrophin-3, NT-3) gelatin sponge cylindrical scaffold for repairing spinal cord injuries, in particular to a method containing overexpressed TrkC receptor A construction method and application of a gelatin sponge scaffold material for sustained release of TrkC receptor ligands from somatic cells. Background technique [0002] Central nervous system injury, such as severe spinal cord trauma, mainly manifests as paraplegia and quadriplegia, and there is no effective treatment method at present. Traditionally, spinal cord nerves are difficult to regenerate after injury. It is now believed that the main reason for the difficulty in spinal cord nerve regeneration is the lack of neurotrophic factors that promote nerve regeneration in their microenvironment. Therefore, artificial intervention is necessary in order to regenerate spinal cord nerves after...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/22A61L27/38A61L27/56A61L27/54
Inventor 曾园山张可
Owner SUN YAT SEN UNIV
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