Polyurethane material with protein adsorption resistance and cell adhesion resistance and preparing method thereof

A polyurethane material, anti-protein adsorption technology, applied in catheters and other directions, can solve the problem of incomplete elucidation of protein adsorption, and achieve the effects of good anti-cell adhesion function, easy control, and easy promotion.

Active Publication Date: 2015-01-07
EAST CHINA UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the study of biocompatibility of materials, the adsorption of proteins on the surface of materials is a very important but still not fully elucidated issue

Method used

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  • Polyurethane material with protein adsorption resistance and cell adhesion resistance and preparing method thereof
  • Polyurethane material with protein adsorption resistance and cell adhesion resistance and preparing method thereof
  • Polyurethane material with protein adsorption resistance and cell adhesion resistance and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Preparation of polyurethane material with anti-protein adsorption and anti-cell adhesion functions

[0034] Preparation of Polyurethane (PU) Diaphragm

[0035] The preparation method of the PU film is as follows: a certain amount of Pellethane2363-80AE (product of Lubrizol company) is dissolved in N,N-dimethylacetamide (DMAc), stirred to make it evenly mixed, and made into 5% (W / V) PU solution. After stirring and dissolving completely, pour it into a glass mold, vacuumize to remove the air bubbles in the solution, then adjust the temperature to 65°C and dry for 48 hours. After the solvent is completely volatilized, the PU film is obtained, and a small PU circular diaphragm with a diameter of 6.0 mm is made with a puncher. Clean with deionized water and ethanol ultrasonically in turn, dry in vacuum and store in a desiccator for later use.

[0036] Preparation of PU-NCO membrane surface

[0037] Add the PU diaphragm to 200mL of 7.5% by mass percent of 4,4'-diphenylmet...

Embodiment 2

[0045] Measurement of water contact angle of polyurethane materials with anti-protein adsorption and anti-cell adhesion functions

[0046] A contact angle measuring instrument was used to test the hydrophilic change of the surface of the PU membrane at various stages of modification. The instrument used was a JC2000D water contact angle measuring instrument, and the results were obtained by using the angle measurement method. The specific operation of the water contact angle test is to fix the polyurethane film to be tested on the glass slide (the polyurethane film to be tested is the polyurethane material with anti-protein adsorption and anti-cell adhesion functions obtained in Example 1), and then drop Put 2 μL of deionized water on the membrane, and measure the left and right angles between the membrane and the water droplet after being stabilized for 10 seconds, and record them. The test results of samples in each stage are the mean and standard deviation of five parallel ...

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Abstract

The invention relates to a polyurethane material with protein adsorption resistance and cell adhesion resistance and a preparing method thereof. The material comprises a substrate and a modification layer. The substrate is made of polyurethane. The modification layer is obtained by polymerizing a vinyl pyrrolidone monomer on the surface of the substrate by utilization of an atom transfer radical polymerization technology. The material is prepared by steps of: subjecting the polyurethane to isocyanic acid esterification, performing amination, fixing a bromine initiator, and initiating graft polymerization of the vinyl pyrrolidone on the surface of the material. The surface of the polyurethane material prepared by the method has good hydrophilicity, good resistance to bovine serum fibrinogen adsorption, bovine serum albumin adsorption and lysozyme adsorption, and a function of resisting cell adhesion of mouse fibroblast cells (L-929), so that the polyurethane material is suitable for preparing biomedical catheter materials with complex shape structures.

Description

【Technical field】 [0001] The invention relates to the field of surface functionalization of biomedical materials, in particular, a polyurethane material with anti-protein adsorption and anti-cell adhesion and a preparation method thereof. 【Background technique】 [0002] Polyurethane (Polyurethane) is a general term for polymers containing carbamate groups (-NHCOO-) in the main chain of the polymer structure. It has a development history of more than 60 years. It has good anticoagulant properties, no allergic reaction, large degree of freedom in molecular design, non-toxic, non-distorting effects, solvent resistance, hydrolysis resistance, antibacterial properties, wear resistance, and controllable performance, so it is It is considered to be one of the most valuable biomedical synthetic materials, and is widely used in artificial hearts and heart assist devices, artificial blood vessels, artificial skin, orthopedic bandages, medical adhesives, catheters, family planning supp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/16C08J7/12A61L29/06A61L29/14
Inventor 蓝闽波张玮袁慧慧薛静钱彬孙博方雪祥
Owner EAST CHINA UNIV OF SCI & TECH
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