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Lincomycin-spectinomycin compound nano-emulsion

A technology of spectinomycin and lincomycin, which is applied in the direction of pharmaceutical formula, emulsion delivery, organic active ingredients, etc., can solve the problems of spectinomycin aqueous solution instability, loss of biological activity, inconvenience of injection, etc., to achieve good biological Improvement of utilization and bioavailability, effect of reducing dosage and frequency of use

Inactive Publication Date: 2015-01-28
HENAN SOAR VETERINARY PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is because the existing dosage forms usually use the hydrochloride form of spectinomycin. Spectinomycin hydrochloride is easily soluble in water, exists in the form of highly polar high-valent ions in the pH environment of the small intestine, and has very little fat solubility. Difficult to absorb when taken orally
Moreover, the spectinomycin aqueous solution is unstable, and it is prone to hydrolysis and thus loses its biological activity.
However, in practice, the treatment of many diseases requires more than 5-7 days of medication, and injection medication is very inconvenient

Method used

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  • Lincomycin-spectinomycin compound nano-emulsion
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Embodiment Construction

[0021] The present invention will be further described below in conjunction with specific embodiments and relevant test experiments.

[0022] 1) Example

[0023] To keep the description brief, specific examples are given below in the form of a list.

[0024] Table 1 List of components of each embodiment

[0025]

[0026] The preparation method of embodiment 1-10 is: take lincomycin hydrochloride and dissolve in distilled water to prepare lincomycin hydrochloride aqueous solution; weigh spectinomycin, surfactant, co-surfactant, stir and mix at room temperature , and then slowly drop in an aqueous solution of lincomycin hydrochloride. As the amount of distilled water increases, the viscosity of the system increases; when the amount of distilled water added makes the system change from water-in-oil to oil-in-water nanoemulsion, the viscosity of the system becomes thinner from the most viscous state, forming a colorless and transparent The nanoemulsion system; add the rem...

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Abstract

The invention provides lincomycin-spectinomycin compound nano-emulsion, and belongs to the technical field of pharmacy. The compound nano-emulsion is prepared from the following components in parts by weight: 1-20 parts of lincomycin hydrochloride, 1-25 parts of spectinomycin, 15-40 parts of surfactant, 1-25 parts of co-surfactant, 1-16 parts of oil and 18-75 parts of water. The compound nano-emulsion is a novel preparation which is combined with characteristics of lincomycin hydrochloride and lincomycin hydrochloride, and has the advantages of uniform grain diameter distribution, good fluidity, high stability, good permeability and good bioavailability; the compound nano-emulsion can be quickly phagocytosed by reticuloendothelial cells after being taken orally, drugs can quickly take effects, and constant plasma concentration and pharmacological effect can be maintained, the bioavailability can be improved, drug effect can be enhanced, and using amount and taking times of the medicine can be reduced.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a lincomycin-spectinomycin compound nanoemulsion. Background technique [0002] Lincomycin Hydrochloride is a white crystalline powder, easily soluble in water or methanol, slightly soluble in ethanol. Lincomycin hydrochloride is a narrow-spectrum antibiotic, its effect is similar to that of erythromycin, and it has a good effect on Gram-positive cocci, especially anaerobic bacteria, Staphylococcus aureus and pneumococcus. Lincomycin hydrochloride can inhibit the protein synthesis of bacterial cells, and it is mainly used clinically for various infections caused by sensitive bacteria, such as pneumonia, meningitis, endocarditis, cellulitis, tonsillitis, erysipelas, furuncle and urinary system infection wait. Because this product can enter bone tissue and has a special affinity with bone, it is especially suitable for infections caused by anaerobic bacteria and sta...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K9/107A61K47/34A61K47/10A61P31/04A61K31/357
CPCA61K31/7056A61K9/1075A61K31/357A61K47/10A61K2300/00
Inventor 孙江宏阮心洁王胜乐张军强
Owner HENAN SOAR VETERINARY PHARMA
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