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A kind of anti-anxiety pharmaceutical composition and application thereof

An anti-anxiety and drug technology, applied in the application field of preparing anti-anxiety drugs, can solve problems such as adverse reactions and seriousness, and achieve the effect of alleviating anxiety

Inactive Publication Date: 2016-08-24
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Before the 1950s, barbiturate sedative hypnotics were mainly used to treat anxiety disorders, but there were serious adverse reactions
Currently, there are no literature reports of 6-bromo-3-acetylindazole having anxiolytic or antidepressant biological activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Mouse elevated plus maze test

[0014] 8-week-old SPF grade Kunming mice, male, eat and drink normally, at room temperature, in a quiet environment. After adaptive feeding for 3 days, the mice were randomly divided into test group A, test group B, positive control group and blank control group according to body weight, with 10 mice in each group. Based on the weight of the mice, each group was intragastrically administered the corresponding test substance at the following doses:

[0015] Blank control group: 0.5% sodium carboxymethylcellulose solution 15ml / kg;

[0016] Positive control group: Diazepam 2mg / kg, suspended evenly with 0.5% sodium carboxymethylcellulose solution;

[0017] Test group A: 6-bromo-3-acetylindazole 100mg / kg, uniformly suspended with 0.5% sodium carboxymethylcellulose solution;

[0018] Test group B: 50 mg / kg of 6-bromo-3-acetylindazole was uniformly suspended with 0.5% sodium carboxymethyl cellulose solution.

[0019] After 0.5...

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PUM

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Abstract

The invention discloses an anti-anxiety pharmaceutical composition and application thereof. The pharmaceutical composition uses 6-bromo-3-acetylindazole as an active ingredient and is made into any conventional oral dosage form acceptable to pharmacy, which can be used for treating anxiety. The invention obtains a better effect of alleviating anxiety, and provides a new choice for medicine production and clinical medicine.

Description

technical field [0001] The invention belongs to the technical field of biological activity application of compounds, and specifically relates to the application of an anxiolytic drug prepared with an indazole compound as an active ingredient. Background technique [0002] Anxiety disorder, also known as anxiety neurosis, is a neurosis dominated by anxiety. Movement restlessness and other symptoms. Studies have shown that patients with anxiety disorders account for about 4%-6% of the world's total population. The survey found that about 4.1% of the people in our country suffer from or have ever suffered from anxiety disorders. If anxiety disorders are left untreated for a long time, 40% to 50% will deteriorate into depression. The pathogenesis of anxiety disorders is still unclear, and the neurotransmitter hypothesis and the neuroendocrine dysfunction hypothesis are generally accepted at present. There are many factors that cause anxiety disorders, which are mainly believ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/416A61P25/22
CPCA61K31/416
Inventor 肖健张宏宇王周光时洪雪刘彦隆吴疆
Owner WENZHOU MEDICAL UNIV