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Compound ceftiofur sodium injection

A technology of ceftiofur sodium and injection, which is applied in the field of compound preparations of β-lactam antibiotics, can solve problems such as complex antigenic determinants, inaccurate immune effects, and differences in immune mechanisms, and achieve good therapeutic effect and high antibacterial activity , the effect of reducing the dosage

Active Publication Date: 2015-02-18
CHONGQING TAITONG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, vaccine immunization, due to the complexity of intestinal microbial antigens and epitopes, the immune mechanism is slightly different, and the immune effect is not exact
With the clinical abuse of antibacterial drugs, the resistance of bacteria such as Escherichia coli is very common, such as gentamicin, oxytetracycline, norfloxacin and other drugs commonly used in clinical efficacy are reduced

Method used

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  • Compound ceftiofur sodium injection
  • Compound ceftiofur sodium injection
  • Compound ceftiofur sodium injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012]

[0013] Add ceftiofur sodium and glycine to 300ml water for injection in turn; dissolve Tween and sodium sulfite in 400ml water for injection, and slowly add magnolol with stirring until completely dissolved; combine the two solutions, add water for injection to 1000ml, Add active carbon to stir, filter, sterilize, and fill.

Embodiment 2

[0015]

[0016] Add ceftiofur sodium and glycine to 300ml water for injection in turn; dissolve Tween and sodium sulfite in 400ml water for injection, and slowly add magnolol with stirring until completely dissolved; combine the two solutions, add water for injection to 1000ml, Add active carbon to stir, filter, sterilize, and fill.

Embodiment 3

[0018]

[0019] Add ceftiofur sodium and glycine to 300ml water for injection in turn; dissolve Tween and sodium sulfite in 400ml water for injection, and slowly add magnolol with stirring until completely dissolved; combine the two solutions, add water for injection to 1000ml, Add active carbon to stir, filter, sterilize, and fill.

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PUM

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Abstract

The invention provides a compound ceftiofur sodium injection with significant antibacterial action. The compound ceftiofur sodium injection comprises the following components in parts by weight: 1-4 parts of ceftiofur sodium, 1-2 parts of magnolol, 0.5-1 part of sodium sulfite, 0.5-1 part of glycine and 1-2 parts of Tween. The injection disclosed by the invention is high in stability and simple in preparation process, has a good inhibiting effect on swine escherichia coli, has an accurate curative effect on porcine colibacillosis, is capable of reducing the dosage of a prescribed preparation and shortening the treatment cycle, and has a wide market prospect.

Description

technical field [0001] The invention relates to a compound preparation of β-lactam antibiotics, in particular to an injection of ceftiofur sodium and magnolol. Background technique [0002] Porcine colibacillosis is a group of intestinal infectious diseases of piglets caused by pathogenic Escherichia coli. There are three common types of piglet diarrhea, piglet pullorum and piglet edema, which are characterized by enteritis and enterotoxemia. Swine dysentery, also known as early-onset colibacillosis, is an acute and fatal infectious disease of newborn piglets caused by a certain serotype of Escherichia coli. It mainly occurs in piglets within a few hours after birth to within 5 days of age, and is most common at 1-3 days of age. Pullorum is also known as delayed colibacillosis. It mainly infects piglets aged 10-30 days. It has happened in many pig farms in our country. Swine edema disease is an acute fatal disease caused by the toxin produced by the massive reproduction...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K9/08A61K47/34A61P31/04A61K31/05
CPCA61K9/0019A61K9/08A61K31/05A61K31/546A61K47/34A61K2300/00
Inventor 李良洪
Owner CHONGQING TAITONG ANIMAL PHARMA
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