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Application of Thrombopoietin in Intestinal Tissue Injury Caused by Radiation

A technology of thrombopoietin and tissue damage, applied in the field of medicine, can solve the problem of high cost

Active Publication Date: 2017-05-17
SHENYANG SUNSHINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Melatonin and octreotide have a certain protective effect on the intestinal damage caused by radiation in mice; in addition, hyperbaric oxygen therapy is also one of the potential methods for the treatment of chronic radiation enteritis, but it costs a lot and needs to go to Professional treatment institutions with considerable experience

Method used

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  • Application of Thrombopoietin in Intestinal Tissue Injury Caused by Radiation
  • Application of Thrombopoietin in Intestinal Tissue Injury Caused by Radiation
  • Application of Thrombopoietin in Intestinal Tissue Injury Caused by Radiation

Examples

Experimental program
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Effect test

Embodiment 1

[0023] TPO improves the survival rate of radiation-damaged mice

[0024] The experimental animals were C57BL / 6 mice, aged 6-8 weeks, weighing 18-20g, and the radiation source was Co 60 , radiation dose 8Gy. All mice were divided into 5 groups according to different doses, 10 in each group, treated with different doses of TPO drugs within 2 hours after radiation and administered continuously for 14 days, the control group was given placebo, and the administration method was intraperitoneal subcutaneous injection. After radiation, the mice were administered according to the experimental plan, and the state changes and daily death of the mice were recorded at the same time. Survival results see figure 1 .

Embodiment 2

[0026] After lethal dose of radiation injury, the repair of intestinal tissue by TPO administration at different times

[0027] A. Model diagram of intestinal repair experiment after radiation injury (see figure 2 )

[0028] According to the survival rate experiment, it is determined that the optimal TPO dosage after radiation is 50 μg / kg, so the TPO administration group set in the next experiment is this dosage group, and the C57BL / 6 mice are selected, and the age of the week is generally at 6-8 weeks, body weight 18-20g, in order to increase the degree of intestinal damage, the radiation dose was increased to 10Gy, and the radiation source was Co 60 . The experimental mice were divided into two groups, the TPO treatment group and the blank control group, 10-15 in each group, and were given TPO drug treatment and placebo treatment within 2 hours after radiation, for 14 consecutive days, and the way of administration was abdominal Subcutaneous injection.

[0029] In the e...

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Abstract

The invention belongs to the field of medicines, and particularly relates to an application of thrombopoietin in intestinal tissue damages caused by radiation.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of thrombopoietin (TPO) in intestinal tissue damage caused by radiation. Background technique [0002] TPO is an endogenous cytokine that stimulates the growth and differentiation of megakaryocytes. It can stimulate all stages of megakaryocyte formation, including the proliferation of precursor cells and the development and maturation of polyploid megakaryocytes, thereby increasing the number of platelets. Recent studies have shown that TPO can significantly promote the recovery of radiation-damaged hematopoietic stem cells. However, no effective solution has been found for the intestinal injury caused by radiation during radiotherapy. TPO can promote the repair of intestinal tissue after radiation injury, and may solve the serious intestinal injury problem in acute radiation sickness. [0003] Tumor radiation therapy is a method of using radiation to treat ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/19A61P1/00A61P7/00A61K31/4045A61K38/08
Inventor 娄竞靳征王超
Owner SHENYANG SUNSHINE PHARMA