Pharmaceutical composition for treating bovine pneumonia and preparation method of pharmaceutical composition for treating bovine pneumonia

A composition, the technology of bovine pneumonia, applied in the field of animal medicine, can solve the problems of large side effects, reduce economic benefits, affect the flavor of meat, etc., achieve the effects of low drug resistance, no pollution to the environment, and improve disease resistance

Inactive Publication Date: 2015-03-04

SHANDONG NEW HOPE LIUHE GROUP

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AI-Extracted Technical Summary

Problems solved by technology

However, the side effects of the current western medicine treatment are relatively large, especially the application of some antibiotics, resulting in more and more dr...

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Method used

Fructus Schizandra: warm in nature, sour in the mouth, sweet, return lung, heart, kidney meridian, Tang etc. " newly revised book on Chinese herbal medicine " carry " the sweet and sour skin and flesh of the five flavors, hard in the nucleus, all have salty taste ", so the name of Fructus Schizandra is arranged. In ancient medical books, it is called Chuzhu, Xuanji, and Huiji, which were first listed in the top grade of Shennong’s Herbal Classic. The efficacy of traditional Chinese medicine lies in the power of nourishing and strengthening, and its medicinal value is extremely high. It is usually used with selenium to make liver-nourishing tablets, bifendate, and bicyclic alcohol. Tablets, etc., have the function of protecting the liver. Schisandra is divided into 2 genera, namely Southern Schisandra and Schisandra. This tree species is easy to plant, thick and has a high survival rate. It has the effects of astringent and astringent, nourishing qi and promoting body fluid, invigorating the kidney and calming the heart. It is used for chronic cough and dyspnea, nocturnal emission, enuresis, frequent urination, chronic diarrhea, spontaneous sweating, night sweats, thirsty body fluid wound, short breath and pulse deficiency, internal heat and quenching thirst, Palpitations, insomnia, etc. Schisandra has anti-inflammatory effects to stop liver damage, activates anabolic processes to promote the repair of damaged liver cells, and can enhance the activity of deoxyribonucleic acid (DNA) synthesis and ornithine decarboxylase to regenerate liver cells.

Wild balsam pear: bitter smell, nontoxic, cold in nature, enter the heart, liver, spleen, lung meridian. It has the effects of clearing away heat and heat, improving eyesight and detoxification, lowering blood pressure and lowering blood sugar, diuresis and cooling blood, relieving fatigue and clearing heart, nourishing qi and strengthening yang. It has the effects of cooling and quenching thirst, clearing heat and detoxification, clearing heart and improving eyesight, replenishing qi and relieving fatigue, benefiting kidney and diuresis. Bitter gourd contains a variety of vitamins and minerals, and contains special ingredients for fat removal and weight loss, which can accelerate detoxification. According to research, it also has good hypoglycemic, antiviral and anticancer effects. Indications for heat stroke, summer heat and polydipsia, heat boils, excessive prickly heat, dysentery, sores, conjunctivitis, red eyes and swelling pain, carbuncle erysipelas, burns, oliguria and other diseases. In a...

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Abstract

The invention provides a pharmaceutical composition for treating bovine pneumonia and a preparation method of the pharmaceutical composition for treating bovine pneumonia. The pharmaceutical composition is prepared from the following medicinal raw material: houttuynia cordata, triumfetta rhomboidea, fructus schizandrae, dicliptera chinensis, uncaria, sweet wormwood, almond, tussilago farfara, radix isatidis, rhizoma anemarrhenae, caulis perllae, zehneria mysorensis arn, lygodium japonicum, Japanese cayratia herb, Japanese ardisia, folium eriobotryae, fructus chebulae, hypericum japonicum, puffball, tamarix chinensis, licorice root, delavay falsepanax herb, fragile blueberry, Chinese white birch sap, water-dragon, Yunnan pleione tuber, peganum harmala and herb of hairystalk loosestrife. The pharmaceutical composition for treating bovine pneumonia can be used for improving the disease resistance of the bovine and boosting the immunity of the bovine while achieving the effects of clearing away heat and toxic materials, freeing lungs and relieving asthma, has the advantages of being purely natural, free of disease resistance, residues and toxic and side effects, strong in pertinence, remarkable in curative effect by directly reaching lesion, and the like. Moreover, the pharmaceutical composition has a function of promoting growth of cow to some extent.

Application Domain

Fungi medical ingredientsPill delivery +5

Technology Topic

AsthmaPeganum harmala +11

Image

Examples

Experimental program(3)
Effect test(1)

Example Embodiment

[0061] Example 1 Granules

[0062] 40 parts of houttuynia cordata, 20 parts of schisandra, 30 parts of schisandra, 25 parts of dog liver, 15 parts of Uncaria, 14 parts of Artemisia annua, 25 parts of almond, 20 parts of coltsfoot, 20 parts of Radix Isatidis, 16 parts of Anemarrhena, 16 parts of Sugen 15 parts, wild bitter gourd 25 parts, sea golden sand 10 parts, blackberry 15 parts, flat wood 15 parts, loquat leaves 20 parts, myrobalan 15 parts, eargrass 10 parts, puffball 20 parts, Tamarix 20 parts, licorice 20 parts, 14 parts of Liangwang tea, 30 parts of earthen-millennium health, 4 parts of birch tree sap, 15 parts of lagoon snake, 25 parts of Bletilla striata, 4 parts of Camelia punctatus and 15 parts of Pai Caoxiang.

[0063] The preparation process is:

[0064] Step 1: Mix the raw medicinal materials according to the stated ratio, add 5 times the alcohol concentration of 90% ethanol to the mixture, heat to boil and reflux for 4 hours, filter, and use percolation at a rate of 2ml per minute. Percolate, collect the percolate, then concentrate it to a paste with a relative density of 1.12 at 60°C under a vacuum of 0.08Mpa, spray dry, the inlet air temperature of the spray dryer is 165°C, and the outlet air temperature is 85°C. Crush into powder to make dry paste powder;

[0065] Step 2: Add 0.1 times the mass of sucrose powder and 0.1 times the dextrin to the obtained dry paste powder to form granules, and dry them at 30° C. to obtain granules.

Example Embodiment

[0066] Example 2 Tablets

[0067] 40 parts of houttuynia cordata, 20 parts of schisandra, 30 parts of schisandra, 25 parts of dog liver, 15 parts of Uncaria, 14 parts of Artemisia annua, 25 parts of almond, 20 parts of coltsfoot, 20 parts of Radix Isatidis, 16 parts of Anemarrhena, 16 parts of Sugen 15 parts, wild bitter gourd 25 parts, sea golden sand 10 parts, blackberry 15 parts, flat wood 15 parts, loquat leaves 20 parts, myrobalan 15 parts, eargrass 10 parts, puffball 20 parts, Tamarix 20 parts, licorice 20 parts, 14 parts of Liangwang tea, 30 parts of earthen-year-old health, 4 parts of birch sap, 15 parts of lagoon snake, 25 parts of Bletilla striata, 4 parts of Camelia striata, 15 parts of Pai Caoxiang, 2 parts of Gewang, 3 servings of Mosaic arrowroot, 20 servings of Shui Maohua and 20 servings of Aristolochia.

[0068] The preparation process is:

[0069] In the first step, the raw medicinal materials are mixed in proportions, and ethanol with an alcohol concentration of 85% relative to the mass of the mixture is added, heated to reflux for 2 hours, extracted and filtered to obtain the first extract; the dregs obtained by filtration are then added Ethanol with an alcohol concentration of 85% relative to the mass of the drug residue is heated to reflux for 2 hours, extracted and filtered to obtain a second extract; the first extract and the second extract are combined and concentrated under reduced pressure to remove the ethanol solvent , Dry to obtain a dry paste;

[0070] In the second step, the dry paste obtained in the first step is placed in an ultra-fine pulverizer and pulverized for 1 hour, pulverized, and sieved to obtain an ultra-fine powder of 300 mesh;

[0071] In the third step, add the microcrystalline cellulose, 0.01 times lactose, and 0.01 times starch to the superfine powder obtained in the second step, sieving, mixing uniformly, granulating, drying, adding relative to its mass The ultra-fine powder has a mass of 0.005 times the magnesium stearate, which is whole and compressed into tablets.

Example Embodiment

[0072] Example 3 Decoction

[0073] 35 parts of houttuynia cordata, 20 parts of cylindromes, 25 parts of schisandra, 25 parts of dog liver, 10 parts of Uncaria, 14 parts of Artemisia annua, 20 parts of almonds, 20 parts of coltsfoot, 15 parts of Radix Isatidis, 16 parts of Anemarrhena, 16 parts of Sugen 15 parts, wild bitter gourd 30 parts, sea golden sand 10 parts, blackberry 20 parts, flat wood 15 parts, loquat leaves 20 parts, myrobalan 15 parts, eargrass 20 parts, puffball 15 parts, tamarisk 20 parts, licorice 20 parts, 14 parts of Liangwang tea, 25 parts of earthen thousand-year health, 10 parts of birch sap, 15 parts of tang snake, 25 parts of Bletilla striata, 4 parts of Camelia pterocarpus, 15 parts of Pai Caoxiang, 5 parts of Gewang, 3 servings of Mosaic arrowroot, 20 servings of Shui Maohua and 20 servings of Aristolochia.

[0074] The preparation process is:

[0075] Mix the raw medicinal materials into a purple casserole pot, add clear water until the water soaks 5 cm of the upper surface of the medicinal materials, and soak for 10 hours; place the purple casserole pot on the fire, and after the fire is boiled, use a slow fire to fry for 50 minutes until the liquid The dosage is 300ml, filter to obtain filtrate a, and reserve; add the remaining medicine residue again to clear water, until the clear water soaks the upper surface of the medicinal material 3cm, soak for 10 hours; put the purple casserole pot on the fire, after the fire is boiled, use a slow fire Decoction for 35 minutes until the dosage of the liquid medicine is 300ml, filter to obtain filtrate b, and mix filtrate a and filtrate b.

[0076] Toxicity test of pharmaceutical composition

[0077] ①Test drugs:

[0078] Medicine one: 35 parts of Houttuynia cordata, 10 parts of Acanthopanax esculenta, 25 parts of Schisandra, 15 parts of dog liver, 10 parts of Uncaria, 10 parts of Artemisia annua, 20 parts of almonds, 10 parts of coltsfoot, 15 parts of Radix isatidis , Anemarrhena 10 parts, Sugen 15 parts, Wild bitter gourd 25 parts, Haijinsha 10 parts, Black berry 15 parts, Flat wood 15 parts, Loquat leaves 10 parts, Myrobalan 15 parts, Dia ear grass 10 parts, Puffball 15 parts, 10 parts of Tamarix, 20 parts of Licorice, 10 parts of Liangwang Tea, 25 parts of Earthen Millennium Health, 4 parts of birch sap, 15 parts of Pond Snake, 20 parts of Bletilla striata, 4 parts of Camelia vulgaris, 10 parts of Pai Cao Xiang Put the mixture into a purple casserole pot, add water until the water has soaked 5cm on the upper surface of the medicinal material, and soak for 10 hours; put the purple casserole pot on the fire, after the fire is boiled, slowly fry for 50 minutes on a slow fire until the dose of the medicinal solution is 300ml , Filter to obtain filtrate a, set aside; add the remaining medicinal residue again to clear water, until the clear water soaks the upper surface of the medicinal material 3cm, soak for 10 hours; put the purple casserole pot on the fire, after the fire is boiled, switch to slow frying for 35 minutes until The dosage of the medicinal solution is 300ml, filtered to obtain filtrate b, and just mix filtrate a and filtrate b.

[0079] Medicine 2: 40 parts of the raw materials Houttuynia cordata, 20 parts of Acanthopanax japonicum, 30 parts of Schisandra, 25 parts of Dog liver, 15 parts of Uncaria, 14 parts of Artemisia annua, 25 parts of almonds, 20 parts of Coltsfoot, 20 parts of Radix isatidis , Anemarrhena vulgaris 16 parts, Sugen 20 parts, Wild bitter gourd 30 parts, Haijinsha 20 parts, Black berry 20 parts, Flat wood 25 parts, Loquat leaves 20 parts, Myrobalan 20 parts, Ear grass 20 parts, Puffball 20 parts, 20 parts of Tamarix, 30 parts of licorice, 14 parts of Liangwang tea, 30 parts of Earthen Qianjian, 10 parts of birch tree sap, 20 parts of Snake, 25 parts of Bletilla striata, 4 parts of Camelia serrata, 15 parts of Pai Cao Xiang Mix 5 parts, 5 parts of Gewang, 5 parts of Arrowroot, 20 parts of Spruce and 30 parts of Aristolochia, put in a purple casserole, add water until the water soaks 5 cm of the upper surface of the medicinal material, soak for 10 hours; Put the purple casserole on the fire. After the fire is boiled, use a slow fire for 50 minutes until the dosage of the medicinal solution is 300ml, filter to obtain the filtrate a, and use it again; add the remaining medicinal residue again to the clear water until the clear water soaks the upper surface of the medicinal material 3cm , Soak for 10 hours; put the purple casserole on the fire, after the fire is boiled, use a slow fire for 35 minutes until the dosage of the medicinal solution is 300ml, filter to obtain filtrate b, and mix filtrate a and filtrate b.

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Classification and recommendation of technical efficacy words

Improve disease resistance
Improve immunity

Pharmaceutical composition for treating bovine pneumonia and preparation method of pharmaceutical composition for treating bovine pneumonia

AI-Extracted Technical Summary

Problems solved by technology

Method used

Abstract

Image

Examples

Example Embodiment

Example Embodiment

Example Embodiment

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Description & Claims & Application Information

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