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Novel use of broadleaf holly leaf in preparation of drugs for Alzheimer's disease

A kind of Kudingcha extract and the technology of Kudingcha, which are applied in the new application of Kudingcha extract and the total flavonoids of Kudingcha, in the field of preparation of drugs for the treatment of Alzheimer's disease, achieving high safety effects

Inactive Publication Date: 2015-03-25
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] At present, there is no literature to mention that Hollyaceae Kudingcha or the total flavonoids of Kudingcha can be used for the treatment of Alzheimer's disease

Method used

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  • Novel use of broadleaf holly leaf in preparation of drugs for Alzheimer's disease
  • Novel use of broadleaf holly leaf in preparation of drugs for Alzheimer's disease
  • Novel use of broadleaf holly leaf in preparation of drugs for Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Take 10kg of Kudingcha, grind it, add 40% ethanol and heat it under reflux to extract three times, each time the amount of ethanol is 10 times the total weight of the medicinal materials, each extraction time is 60 minutes, the extraction temperature is 60 ° C, the extracts are combined and concentrated , filtered to obtain Kudingcha extract.

Embodiment 2

[0046] Take 10kg of Kudingcha and pulverize it, add 40% ethanol for microwave extraction three times, each time the amount of ethanol is 10 times the total weight of the medicinal materials, each extraction time is 10 minutes, the extraction temperature is 50 ° C, the combined extracts are concentrated, Filter, adsorb on ADS-17 resin, elute with 90% ethanol, collect the eluate, concentrate and dry to obtain the total flavonoids of Kudingcha.

[0047] Taking rutin as the reference substance, the yield of total flavonoids in Kudingcha was 2.91%.

Embodiment 3

[0049] Take 10kg of Kudingcha, grind it, pass through a 80-mesh sieve, add 70% ethanol and 780W microwave extraction three times, each time the ethanol dosage is 15 times the total weight of the medicinal materials, each extraction time is 5 minutes, and the extraction temperature is 80°C , combine the extracts, concentrate, add diatomaceous earth to filter, pass through ADS-17 resin adsorption, elute with 90% ethanol, collect the eluate, concentrate and dry to obtain the total flavonoids of Kudingcha.

[0050] Rutin was used as the reference substance. The yield of total flavonoids in Kudingcha was 3.67%.

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Abstract

The invention relates to a novel use of broadleaf holly leaf, i.e., novel use of broadleaf holly leaf in preparation of drugs for Alzheimer's disease, and specifically novel use of broadleaf holly leaf extractant and broadleaf holly leaf general flavone in preparation of drugs for Alzheimer's disease.

Description

technical field [0001] The invention relates to a new application of Kudingcha, in particular to a new application of Kudingcha extract and total flavonoids of Kudingcha, that is, a new application in the preparation of drugs for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) and vascular dementia (VD) are the most common types of senile dementia. "Research Progress on Inflammatory Response in the Pathogenesis of Alzheimer's Disease" published in "Chinese Journal of Gerontology" discloses that AD accounts for 50% to 60% of the total number of dementia patients, and VD accounts for 15% to 20%. Its characteristic pathological changes are neurofibrillary tangles (NFT) in the cerebral cortex and subcortex, formation of a large number of extracellular senile plaques (SP) and loss of neurons. A large number of studies have concluded that β-amyloid protein (βamyloidprotein, Aβ) plays a central role in the pathogenesis of AD, and the neurotoxic...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P25/28
CPCA61K36/185A61K2236/333A61K2236/39
Inventor 刘冠萍贤明华陈瑛张栩颜
Owner GUANGXI WUZHOU PHARMA GRP