Calcium citrate producing method

A technology of calcium citrate salt and production method, applied in the directions of carboxylate preparation, carboxylate preparation, chemical instruments and methods, etc., can solve the problems of energy consumption and consumption of many raw and auxiliary materials, complicated procedures, and generation of solid waste gypsum, etc.

Active Publication Date: 2015-04-15
COFCO BIOTECHNOLOGY CO LTD
View PDF5 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented process allows for direct extraction without first removing any other substances like citrates beforehand. Additionally, this process produces highly pure calciumcitrite which meets certain criteria such as those set out in UF standard guidelines (US pharmaceutical products) and Food Additives Standard Code X).

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the efficiency of producing highly pure forms of calcious acids like calcitonite without requiring expensive processes involving acidulation, precipitator addition, ion exchange techniques, solvents, etc., resulting in increased manufacturing expenses due to these operations being carried out separately on different products.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Calcium citrate producing method
  • Calcium citrate producing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] This embodiment is used to illustrate the production method of calcium citrate of the present invention.

[0045] 1000ml of citric acid fermentation clear liquid (acidity is 130g / L, turbidity is 20NTU) and 100 grams of heavy calcium carbonate particles (calcium carbonate purity 95% by weight, hydrochloric acid insoluble matter content 3% by weight, heavy metal content 0.5% by weight, Lead content 0.3% by weight, arsenic content 0.2% by weight, fluoride content 0.1% by weight, diameter: 10-400 microns) at 80°C for neutralization reaction, and the pH at the end of the reaction is controlled to be 4.7. Gained neutralization product is carried out suction filtration and obtains free water content and is the thick calcium citrate crystal of 50% by weight, with the hot water washing thick calcium citrate crystal of 2 times of wet calcium citrate volume with total amount, make citric acid Calcium-washed sugar water is oxidized with potassium permanganate for 3 minutes to obtai...

Embodiment 2

[0047] This embodiment is used to illustrate the production method of calcium citrate of the present invention.

[0048] 1000ml of citric acid fermentation liquid (acidity is 130g / L, turbidity is 20NTU) and 100 grams of heavy calcium carbonate particles (calcium carbonate purity 95.5% by weight, hydrochloric acid insoluble content 3% by weight, heavy metal content 0.5% by weight, Lead content 0.3% by weight, arsenic content 0.1% by weight, fluoride content 0.1% by weight, diameter: 10-400 microns) at 75°C for neutralization reaction, and the pH at the end of the reaction is controlled to be 4.6. Gained neutralization product is carried out suction filtration and obtains free water content and is the thick calcium citrate crystal of 50% by weight, with the hot water washing thick calcium citrate crystal of 0.5 times of wet calcium citrate volume with total amount, make citric acid Calcium-washed sugar water is oxidized with potassium permanganate for 3 minutes to obtain rough c...

Embodiment 3

[0050] This embodiment is used to illustrate the production method of calcium citrate of the present invention.

[0051] 1000ml of citric acid fermentation liquid (acidity is 130g / L, turbidity is 20NTU) and 100 grams of heavy calcium carbonate particles (calcium carbonate purity 96% by weight, hydrochloric acid insoluble content 3% by weight, heavy metal content 0.5% by weight, Lead content 0.3% by weight, arsenic content 0.1% by weight, fluoride content 0.2% by weight, diameter: 10-400 microns) at 85°C for neutralization reaction, and the pH at the end of the reaction is controlled to be 4.8. Gained neutralization product is carried out suction filtration and obtains free water content and is the thick calcium citrate crystal of 50% by weight, with the hot water washing thick calcium citrate crystal of 3 times of wet calcium citrate volume with total amount, make citric acid Calcium-washed sugar water is oxidized with potassium permanganate for 3 minutes to obtain rough calci...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a calcium citrate producing method includes following steps: (1) contacting a citric acid fermentation clear liquid with heavy calcium carbonate to obtain a crude calcium citrate crystal; (2) acidically hydrolyzing the crude calcium citrate crystal with hydrochloric acid to obtain a solution and filtering the solution; and (3) contacting a filtrate with one or more of a carbonate of alkali metals, a hydroxide of the alkali metals, an oxide of the alkali metals, ammonium carbonate and ammonium bicarbonate. The producing method can obtain the crude calcium citrate crystal precipitation directly through reaction between the simply-filtered impurity-containing crude citric acid fermentation clear liquid and the heavy calcium carbonate and then the high-purity calcium citrate, which is 99.9-99.99% in purity and can reach a standard in United States Pharmacopeia USP33-NF28 and American food additives FCC5, can be obtain just by performing one filtering process for removing impurities and performing a contact reaction between the obtained filtrate and one or more of the carbonate of alkali metals, the hydroxide of the alkali metals, the oxide of the alkali metals, the ammonium carbonate and the ammonium bicarbonate.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Owner COFCO BIOTECHNOLOGY CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap