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Bioactive hyaluronic acid gel preparation

A technology of hyaluronic acid and biological activity, applied in the direction of organic active ingredients, non-central analgesics, skin care preparations, etc., can solve problems such as adverse side effects, prevent skin inflammation, increase biological activity, and promote skin health Effect

Active Publication Date: 2015-04-29
QINGDAO HUINUODE BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the current drugs for the treatment of skin inflammation, the drugs containing corticosteroids are sure to be effective for various dermatitis, but if they are used frequently or in large quantities for a long time, some adverse side effects will occur

Method used

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  • Bioactive hyaluronic acid gel preparation
  • Bioactive hyaluronic acid gel preparation
  • Bioactive hyaluronic acid gel preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Objective: Production method of bioactive hyaluronic acid fragments.

[0023] Method: The raw material is 200-600KD macromolecular hyaluronic acid with a purity of 90.0%-99.9%, cut with recombinant human hyaluronidase PH20 produced by CHO cells, and using 1000-2000 units of hyaluronidase per gram of hyaluronic acid. Digest at 37 degrees for 4-6 hours, pH5.0-5.5, 130-160mM NaCl, 0.5-1.0mMMgSO 4 , 1.5-2.5mM CaCl 2 , the final molecular weight is 0.7KD-100KD hyaluronic acid fragments.

[0024] At least one end of the hyaluronic acid fragment with a molecular weight of 0.7KD-100KD is the end cleaved by recombinant human hyaluronidase PH20 produced by CHO cells that does not cause allergic reactions in humans, has glycation, and can recognize the normal structure of hyaluronic acid. It has the biological activity of promoting cell secretion of defensin 2, killing microorganisms and inhibiting skin and mucous membrane inflammation. The biological activity depends on both th...

Embodiment 2

[0026] Objective: To study the effects of different gel excipients on the human bioactivity of bioactive hyaluronic acid.

[0027] Method: In this experiment, the method of human experiment was used to detect the biological activity of bioactive hyaluronic acid in human body, that is, the influence of different gel excipients on the effect of bioactive hyaluronic acid on the treatment of skin inflammatory diseases. In the small animal pre-experiment of this experiment, it has been found that the gel excipients hypromellose, methylcellulose, sodium carboxymethylcellulose, chitosan, polyethylene glycol, and sodium alginate all reduce or do not increase the biological activity Human bioactivity of hyaluronic acid. All cases in this experiment were patients with skin inflammatory diseases. Experimental group 1 (carbomer) applied 2% carbomer+3% bioactive hyaluronic acid gel for 6 times a day, and observed the redness and redness of the skin inflammation symptoms after treatment. T...

Embodiment 3

[0041] Objective: To study the effects of different concentrations of carbomer gel excipients on the biological activity of bioactive hyaluronic acid in human body.

[0042] Method: Manufacture bioactive hyaluronic acid 0.6%, 1.5%, 2.0%, 2.5%, 3.0% and carbomer 1.5%, 2.0%, 2.5%, 3.0% gel, without adjusting glycerin, sodium chloride, fragrance, % content of sodium methylparaben and sodium propylparaben. All the cases in this experiment were patients with skin inflammatory diseases. Experimental groups 1-5 used carbomer 1.5% + bioactive hyaluronic acid 0.6%, 1.5%, 2.0%, 2.5%, 3.0% gel respectively, and applied 6% gel every day. Second, observe the redness, damage and itching symptoms of skin inflammation after treatment; the experimental group 6-10 respectively adopts carbomer 2.0% + bioactive hyaluronic acid 0.6%, 1.5%, 2.0%, 2.5%, 3.0% Gel, smeared 6 times a day, observed the redness of skin inflammation, damage and itching symptoms after treatment; experimental groups 11-15 ...

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Abstract

The invention discloses a bioactive hyaluronic acid gel preparation, which comprises bioactive hyaluronic acid with anti-inflammatory activity, and carbomer having synergistic effect together with the bioactive hyaluronic acid. The gel preparation can promote the health of mouth and throat mucosa, and treat syndromes such as cough and the like caused by throat inflammation.

Description

technical field [0001] The invention relates to the fields of skin care and dermatitis medicine, in particular to a bioactive hyaluronic acid gel preparation. Background technique [0002] Skin inflammatory diseases are skin diseases caused by skin inflammation, including simple skin erythema, skin allergies and other visible skin redness, swelling and itching. Inflammatory skin disease (dermatitis) and eczema are often used synonymously to refer to a type of skin inflammation that represents an allergic reaction of the skin to a variety of substances, including chemicals, proteins, bacteria, and fungi. For example, the pathogenesis of scrotal dermatitis is very complicated, which can be simply divided into internal factors and external factors. External factors such as chemical agents, cosmetics, animal toxins, fish and shrimp, pollen, dust, sun exposure, scratching, etc. Mental factors, immune factors of the body, metabolic factors, and psychological factors that are gett...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/78A61K47/32A61K9/06A61P29/00A61P17/00A61K8/81A61Q19/00A61K31/728A61K8/73
Inventor 惠觅宙
Owner QINGDAO HUINUODE BIOLOGICAL TECH CO LTD
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