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Purification method of sulfadoxine

The technology of a cycle-acting sulfonamide and a purification method is applied in the purification field of the cycle-acting sulfonamide, and can solve the problems such as the purity and the yield of the cycle-acting sulfonamide need to be improved, and achieve the effect of improving the purity and the yield.

Inactive Publication Date: 2015-04-29
CHANGSHU JINSHEN MEDICAL PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The production method of existing sulfonamide, the purity and the productive rate of the sulfonamide it produces all need to be improved

Method used

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Embodiment Construction

[0010] The specific implementation of the present invention will be further described below in conjunction with the examples. The following examples are only used to illustrate the technical solution of the present invention more clearly, but not to limit the protection scope of the present invention.

[0011] The technical scheme of concrete implementation of the present invention is:

[0012] A method for purifying sulfonamide, comprising the steps of:

[0013] 1) Add 13.4 parts by mass of deionized water to the reaction vessel, then add 2.4 parts by mass of calcium hydroxide, raise the temperature to 75°C, slowly add 5.3 parts by mass of crude sulfonamide by mass, and then add 1.3 parts by mass of calcium hydroxide to adjust the pH value to 8.4, stir evenly;

[0014] 2) Heat up to 90°C, then add activated carbon, cool naturally, and filter to obtain the filtrate;

[0015] 3) Heat the filtrate to 65°C, add 45% glacial acetic acid solution dropwise, adjust the pH value to ...

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PUM

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Abstract

The invention discloses a purification method of sulfadoxine. The purification method comprises the following steps: 1) adding 13.4 parts by mass of deionized water to a reaction container, next, adding 2.4 parts by mass of calcium hydroxide, increasing the temperature to 75 DEG C, slowly adding 5.3 parts by mass of sulfadoxine crude product, then adding 1.3 parts by mass of calcium hydroxide, regulating the PH value to 8.4, and stirring evenly; 2) increasing the temperature to 90 DEG C, then adding activated carbon, naturally cooling and filtering to obtain the filtrate; 3) increasing the filtrate to 65 DEG C, dropwise adding 45% of glacial acetic acid solution, regulating the PH value to 4.8, standing for precipitating and then centrifugally dehydrating to obtain the filter residue; and 3) drying the filter residue at 145 DEG C for 1 hour, cooling to 25 DEG C and then discharging the material. The purification method is capable of improving the purity and yield of the sulfadoxine.

Description

technical field [0001] The invention relates to a method for purifying sulfonamide. Background technique [0002] In the existing production method of sulfonamide, the purity and the productive rate of the sulfonamide produced by it all need to be improved. Contents of the invention [0003] The object of the present invention is to provide a kind of purification method of sulfonamide, which can improve the purity and productivity of sulfonamide. [0004] In order to achieve the above object, technical scheme of the present invention is to design a kind of purification method of sulfonamide, comprising the steps: [0005] 1) Add 13.4 parts by mass of deionized water to the reaction vessel, then add 2.4 parts by mass of calcium hydroxide, raise the temperature to 75°C, slowly add 5.3 parts by mass of crude sulfonamide by mass, and then add 1.3 parts by mass of calcium hydroxide to adjust the pH value to 8.4, stir evenly; [0006] 2) Heat up to 90°C, then add activated ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/69
CPCC07D239/69
Inventor 李涛
Owner CHANGSHU JINSHEN MEDICAL PROD CO LTD
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