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A kind of preparation method of asymmetric polymer nanosphere

A technology of polymers and nanospheres, which is applied in the direction of medical preparations and pharmaceutical formulas of non-active ingredients, can solve the problems of product insolubility, inconvenient post-processing, and limited application, and achieve controllable particle size and easy operation. The process is simple and easy, and the effect is pioneering

Active Publication Date: 2017-12-22
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is always through the traditional method of introducing a cross-linking agent. Although the obtained shape is relatively new compared to the traditional regular balls, the product is insoluble and insoluble, which is not only inconvenient for post-processing, but also limits its later application.

Method used

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  • A kind of preparation method of asymmetric polymer nanosphere
  • A kind of preparation method of asymmetric polymer nanosphere
  • A kind of preparation method of asymmetric polymer nanosphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 0.2mL of the hydrophilic monomer glycidyl methacrylate, 2mL of the hydrophobic monomer styrene, and 0.4mL of saturated hydrocarbon into a three-necked flask containing 30mL of deionized water, stir with nitrogen for 30-60min, and heat up to 75°C , Then add the aqueous solution that is dissolved with 0.04g potassium persulfate initiator. After reacting for 24 hours, a monodisperse styrene-divinylbenzene-glycidyl methacrylate (PS-PGMA) special-shaped polymer nanosphere emulsion was obtained. SEM images of shaped polymer nanospheres figure 1 shown.

Embodiment 2～5

[0025] Embodiment 2~5: with the process condition of embodiment 1, change the amount of saturated hydrocarbon respectively, synthesize the monodisperse styrene-glycidyl methacrylate (PS-PGMA) special-shaped polymer nanosphere emulsion of different shapes, The results are shown in Table 1.

[0026] Table 1

[0027]

Embodiment 4

[0028] The SEM figure of the polymer nanosphere obtained in embodiment 4 is shown in figure 2 , the SEM figure of the polymer nanosphere obtained in embodiment 5 is shown in image 3 .

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Abstract

A preparation method of asymmetric polymer nanospheres relates to polymer nanospheres. The hydrophilic monomer, the hydrophobic monomer and the saturated hydrocarbon are added into the solvent, nitrogen gas is passed through, the polymerization reaction is carried out after heating, then the initiator solution is added, and the nitrogen gas flow reaction is continued to obtain monodisperse asymmetric polymer nanospheres. It is prepared by one-step synthesis method of soap-free emulsion, which has the advantages of simple operation and uniform and controllable particle size of the obtained product special-shaped microspheres. Since no emulsifier and stabilizer are added, the obtained product is pure, and the subsequent preparation of polymer photonic crystals can be used without any treatment. The obtained product has the advantages of simple post-processing and strong pioneering ability. It has certain application prospects in pharmaceutical fields such as drug release and drug carrier.

Description

technical field [0001] The invention relates to polymer nanospheres, in particular to a preparation method of asymmetric polymer nanospheres. Background technique [0002] In recent years, the application prospects of polymer asymmetric nanospheres in anisotropic photonic crystals, biosensors, and drug delivery vehicles have attracted widespread attention in the scientific community. At present, there are three main methods for the preparation of polymer asymmetric nanospheres, namely: extension of regular spheres, template method and emulsion polymerization. Among them, the extension of regular spheres can only obtain corresponding elliptical spheres, and the application range is limited; the preparation process of template method is complicated and time-consuming, and it is not an effective method for preparing asymmetric nanospheres; emulsion polymerization is not an effective method for preparing polymers. One of the effective methods of symmetric nanospheres can not on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F212/08C08F220/32C08F2/22A61K47/32
Inventor 戴李宗王爽袁丛辉余世荣符泽浩邵志恒罗伟昂许一婷曾碧榕
Owner XIAMEN UNIV