Solid dispersion dropping pill adopting persimmon leaf total flavonoids and preparation method of solid dispersion dropping pill

A technology of solid dispersion and total flavonoids, which is applied in the preparation of solid dispersion drop pills of total flavonoids from persimmon leaves, solid dispersion drop pills of total flavonoids from persimmon leaves, and the field of preparation of solid dispersion drop pills, which can solve the problem of phospholipid complexes Problems such as poor hydrophilicity, difficulty in rapid dissolution, and limitation of bioavailability of total flavonoids from persimmon leaves, etc., to achieve the effects of easy direct continuous production, increased solubility and dissolution rate, and improved water solubility

Active Publication Date: 2015-06-03
SHENYANG DONGXIN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the existing phospholipid complexes of total flavonoids from persimmon leaves have improved the lipophilicity of total flavonoids from persimmon leaves, the phospholipid complexes have poor hydrophilicity and are difficult to dissolve quickly after oral administration, thus limiting the improvement of the bioavailability of total flavonoids from persimmon leaves

Method used

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  • Solid dispersion dropping pill adopting persimmon leaf total flavonoids and preparation method of solid dispersion dropping pill
  • Solid dispersion dropping pill adopting persimmon leaf total flavonoids and preparation method of solid dispersion dropping pill
  • Solid dispersion dropping pill adopting persimmon leaf total flavonoids and preparation method of solid dispersion dropping pill

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Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of embodiment 1 persimmon leaf total flavonoid phospholipid complex

[0040] Weigh 1g of persimmon leaf total flavonoids powder and 2g soybean lecithin (weight ratio is 1:2), add 45mL of acetone (persimmon leaf total flavonoids: reaction medium = 1g: 45mL), connect to the reflux device, stir while heating, and heat to Insulate and react at 55°C for 1.5 hours until the solution is clear, remove the reflux device, connect it to a rotary evaporator, and evaporate to obtain a yellow-white solid, take it out and dry it in a vacuum oven at 40°C, and pass it through a 80-mesh sieve after grinding to obtain a yellowish-white solid. The white powder is obtained (wherein, the total flavonoids of persimmon leaves accounts for 33.3% of the weight of the total flavone-phospholipid complex of persimmon leaves, and soybean lecithin accounts for 66.7%).

Embodiment 2

[0041] The preparation of embodiment 2 persimmon leaves total flavonoid phospholipid complex

[0042] Weigh 1g of persimmon leaf total flavonoids powder and 4g soybean lecithin (weight ratio is 1:4), add 45mL of acetone (persimmon leaf total flavonoids: reaction medium = 1g: 45mL), connect to the reflux device, stir while heating, and heat to Insulate and react at 55°C for 1.5 hours until the solution is clear, remove the reflux device, connect it to a rotary evaporator, and evaporate to obtain a yellow-white solid, take it out and dry it in a vacuum oven at 40°C, and pass it through a 80-mesh sieve after grinding to obtain a yellowish-white solid. Available as white powder.

Embodiment 3

[0043] The preparation of embodiment 3 persimmon leaves total flavonoid phospholipid complex

[0044] Weigh 1g of persimmon leaf total flavonoids powder and 3g soybean lecithin (weight ratio is 1:3), add 45mL of acetone (persimmon leaf total flavonoids: reaction medium = 1g: 45mL), connect to the reflux device, stir while heating, and heat to Insulate and react at 55°C for 1.5 hours until the solution is clear, remove the reflux device, connect it to a rotary evaporator, and evaporate to obtain a yellow-white solid, take it out and dry it in a vacuum oven at 40°C, and pass it through a 80-mesh sieve after grinding to obtain a yellowish-white solid. Available as white powder.

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Abstract

The invention discloses a solid dispersion dropping pill adopting persimmon leaf total flavonoids and a preparation method of the solid dispersion dropping pill, and belongs to the field of preparation of the solid dispersion dropping pill. The invention discloses the solid dispersion dropping pill adopting the persimmon leaf total flavonoids firstly. The solid dispersion dropping pill comprises the following components: a persimmon leaf total flavonoid and phospholipid complex, a water-soluble base and a surfactant. The phospholipid complex is prepared from the persimmon leaf total flavonoids with the phospholipid complex technology, the lipophilicity of the persimmon leaf total flavonoids is improved effectively, and the membrane permeation performance is improved; the solid dispersion dropping pill adopting the persimmon leaf total flavonoids is prepared by taking the persimmon leaf total flavonoid and phospholipid complex as the intermediate, and the water solubility of the persimmon leaf total flavonoid and phospholipid complex is improved effectively, so that the dissolution quantity and dissolution rate of the persimmon leaf total flavonoids are increased. Pharmacokinetic test results show that the oral bioavailability of the persimmon leaf total flavonoids of the prepared solid dispersion dropping pill is improved effectively.

Description

technical field [0001] The present invention relates to a solid dispersion drop pill of total flavonoids from persimmon leaves, in particular to a solid dispersion drop pill with total flavonoids from persimmon leaves phospholipid complex as an intermediate, and the present invention also relates to the solid dispersion drop pills from total flavonoids from persimmon leaves The preparation method belongs to the preparation field of solid dispersion dropping pills. Background technique [0002] Persimmon leaves have the effects of promoting body fluid and quenching thirst, clearing away heat and detoxification, nourishing the lungs and strengthening the heart, relieving cough and stopping bleeding. Persimmon leaves are rich in flavonoids, triterpenoids and vitamins. Among them, the total flavonoids in persimmon leaves have obvious effects of enhancing immunity, anti-fatigue, and anti-ischemic damage. The clinical efficacy of the metabolic syndrome is definite, and it has the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/44A61K9/20A61K47/24A61P37/04A61P39/00A61P9/10A61P3/10A61P3/06A61P9/12
Inventor 李红岩唐星张宇何海冰徐荷林
Owner SHENYANG DONGXIN PHARMA CO LTD
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