The invention relates to the field of house construction, and provides a construction method for impermeability leakage prevention of a secondary structure aiming at the problem that an impermeable effect of a secondary structure is reduced because a waterproof layer easily falls off. The technical solution is as follows: the method comprises the following steps: step 1, building a reinforced barframe; step 2, building a casting template; step 3, pouring impermeable concrete; step 4, disassembling a casting template after the impermeable concrete is initially settled; and step 5, sprinkling water for curing, wherein the impermeable concrete comprises the following components, in parts by mass: 100 parts of Portland cement, 300-400 parts of coarse aggregate, 200-250 parts of fine aggregate, 100-150 parts of a nano filler, 30-50 parts of an adhesive, and 90-110 parts of water. According to the method provided by the invention, the nano filler is added into the impermeable concrete to fill gaps and fine pores in the concrete structure, the adhesive fills crack fine pores in the concrete structure, so that the concrete structure is very compact, the impermeability of the concrete structure is improved, even without addition of a waterproof layer, the impermeable effect is better and more stable, and the construction is more convenient.