Cavity, soft tissue perfusion culture system and soft tissue stretchability test system
A test system and soft tissue technology, applied in tissue cell/virus culture devices, biochemical instruments, biochemical equipment and methods, etc., can solve the problem of inaccurate control of the stretching amount, and achieve aseptic and perfusion culture, Improve the effect of precise control and convenient accuracy
Active Publication Date: 2015-06-03
XI AN JIAOTONG UNIV
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Problems solved by technology
[0003] Many foreign research groups have confirmed that periodic mechanical loading on the constructed muscle tissue, simulating the growth and development process of skeletal muscle tissue in vivo, can significantly affect the activity, life cycle and contractile function of the regenerated muscle tissue. However, in the soft tissue When stretching, it is difficult to obtain conditions such as sterile environment and perfusion culture. At the same time, when stretching soft tissues, the amount of stretching cannot be accurately controlled
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[0033] The present invention is described in further detail below in conjunction with accompanying drawing:
[0034] refer to figure 1 , figure 2 and image 3 The chamber according to the present invention includes an upper structure 1, a lower structure 2, two fixing blocks 6 and two fixing parts 10, the lower surface of the upper structure 1 and the upper surface of the lower structure 2 are provided with first grooves, The first groove on the upper structure 1 and the first groove on the lower structure 2 form a sealed cavity 3, and the upper structure 1 is provided with a liquid inlet 4, and the lower structure 2 is provided with a liquid outlet 5 , the liquid inlet 4 and the liquid outlet 5 are connected with the cavity 3, the side of the fixed block 6 is provided with a second groove, and one end of the upper structure 1 and one end of the lower structure 2 are embedded in a fixed block 6, the other end of the upper structure 1 and the other end of the lower structur...
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The invention discloses a cavity, a soft tissue perfusion culture system and a soft tissue stretchability test system. The cavity comprises an upper layer structure, a lower layer structure, two fixing blocks and two fixing parts. The soft tissue perfusion culture system comprises a liquid charge pump, a three-way valve, a liquid collecting device and the cavity. The soft tissue stretchability test system comprises a first fixture fixing plate, a second fixture fixing plate, a step motor, a base, a first fixing plate, a second fixing plate, an optical shaft, a linear sliding shaft and the soft tissue perfusion culture system. By utilizing the cavity, the soft tissue perfusion culture system and the soft tissue stretchability test system, the aseptic environment and perfusion culture conditions can be obtained when the soft tissue is stretched, and meanwhile, the stretching degree of the soft tissue can be controlled accurately.
Description
technical field [0001] The invention belongs to the field of mechanical automation and biotechnology, and relates to a chamber, a soft tissue perfusion culture system and a soft tissue tensile test system. Background technique [0002] Tissues in the body are in a complex growth environment, in which mechanical stimuli greatly affect the morphological structure and function of the tissue. Continuous passive tension promotes the lengthening and thickening of skeletal muscle tissue during human development, and physical labor and physical exercise can also increase the number and diameter of muscle fibers. Under physiological conditions, mechanical stress is an important extracellular stimulus to maintain cell survival and growth, affect cell growth behavior, regulate cell metabolism and gene expression process, and play an important role in cell activation, proliferation and differentiation. Studies have shown that mechanical stretching has a two-way effect on myoblasts. App...
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Inventor 连芩毛伟陈成李志朝贺健康李涤尘
Owner XI AN JIAOTONG UNIV