Electrical impedance measurement system abnormity detection method based on multi-feature combination and system thereof

An electrical impedance measurement, multi-feature technology, applied in the field of blood cell analysis, to reduce the inaccuracy of count values ​​and cell volume measurement, and improve sensitivity and accuracy

Active Publication Date: 2015-06-10
SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of this application is to provide a multi-feature-based abnormality detection method and system for the electrical impedance measurement system to improve the sensitivity and accuracy of

Method used

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  • Electrical impedance measurement system abnormity detection method based on multi-feature combination and system thereof
  • Electrical impedance measurement system abnormity detection method based on multi-feature combination and system thereof
  • Electrical impedance measurement system abnormity detection method based on multi-feature combination and system thereof

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Experimental program
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Embodiment 1

[0051] In this embodiment, the abnormal state of the electrical impedance measurement system is detected by combining the characterization parameter of the pinhole voltage and the characterization parameter of the particle number.

[0052] Among them, the characterization parameter of the pinhole voltage is the ratio of the standard deviation of the pinhole voltage sequence to the average value, and the characterization parameter of the particle number is the ratio of the standard deviation of the particle number sequence to the average value; the pinhole voltage sequence is the The sequence formed by the pinhole voltage, the particle number sequence is the sequence formed by the number of particles in multiple unit times; the unit time of collection can be 0.1s or 0.2s, which is determined according to the data sampling rate of the instrument.

[0053] Specifically, this embodiment includes the following steps:

[0054] S101. Collect signals of pinhole voltage and particle nu...

Embodiment 2

[0066] In this embodiment, the abnormal state of the electrical impedance measurement system is detected by combining the characterization parameters of the pinhole voltage and the characterization parameters of the cell distance.

[0067] Among them, the characteristic parameter of the cell distance is the ratio of the standard deviation of the cell distance sequence to the average value, and the cell distance sequence is a sequence formed by the arithmetic mean value of the cell distance per unit time, for example, several cell distances are collected within 1 second The arithmetic mean value of the data is obtained, and the average value of the cell distance in 10 seconds forms a cell distance sequence; the definition of the characterization parameters of the pinhole voltage is the same as that in Example 1, and will not be repeated here.

[0068] Specifically, this embodiment includes the following steps:

[0069] S201. Collect the pinhole voltage and intercellular distanc...

Embodiment 3

[0080] In this embodiment, the abnormal state of the electrical impedance measurement system is detected by combining the characteristic parameter of the cell distance and the characteristic parameter of the particle number.

[0081] Wherein, the definition of the characteristic parameter of the number of particles is the same as that of the first embodiment, and the definition of the characteristic parameter of the distance between cells is the same as that of the second embodiment, and will not be repeated here.

[0082] Specifically, this embodiment includes the following steps:

[0083] S301. Collect the cell distance and the number of particles of the electrical impedance measurement system.

[0084] S302. Calculate the corresponding characteristic parameter and substitute it into a decision function to calculate the function value.

[0085]Wherein, the determination function is a function related to the characteristic parameters of cell distance and particle number, whi...

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Abstract

The invention relates to an electrical impedance measurement system abnormity detection method based on multi-feature combination and the system thereof. The method comprises the following steps: employing signals of at least two features of the electrical impedance measurement system; calculating characterization parameter of each feature, substituting in a decision function, calculating to obtain a function value; wherein the decision function is a function relative to the characterization parameter of at least two features; comparing the function value and a threshold scope, when the function value is not in the threshold scope, the electrical impedance measurement system is determined as abnormity. According to the provided electrical impedance measurement system abnormity detection method based on multi-feature combination and the system, at least two features of the electrical impedance measurement system are combined for abnormity state detection, alarming sensitivity and accuracy of the electrical impedance measurement system under abnormity can be effectively increased, and the problem of inaccurate measurement of counting value and cell volume due to abnormity of the electrical impedance measurement system can be reduced.

Description

technical field [0001] The present application relates to the field of blood cell analysis, in particular to a method and system for abnormality detection of an electrical impedance measurement system based on multi-feature combination. Background technique [0002] Blood cell analyzer is the most commonly used clinical testing instrument for counting and classifying various constituent cells in blood, and plays an important role in clinical medicine, teaching, scientific research and other work. [0003] At present, the electrical impedance detection method using the Coulter principle (the Coulter principle) is the main method for classification and counting of blood cell analyzers. Its principle is to measure the particles in the fluid according to the different resistances of the particles with different volumes passing through the detection hole in the fluid. For example, the blood cells in the blood are relatively poor conductors. When the blood cells suspended in the ...

Claims

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Application Information

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IPC IPC(8): G01N15/12
Inventor 章颖狄建涛祁欢叶波
Owner SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
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