A kind of veterinary interferon inducer and preparation method thereof

An interferon-induced, aqueous solution technology, applied in the directions of non-active ingredients medical preparations, antidote, pharmaceutical formulations, etc., can solve the problems of sodium metabisulfite being too toxic to be swallowed, unfavorable to the production and operation of workshop personnel, and side reactions, etc. Avoid antibiotic and toxic residues, no food safety issues, avoid degradation effects

Active Publication Date: 2017-11-10
SOUTH CHINA AGRI UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Substances such as sodium pyrosulfite and excipients are likely to irritate the body to varying degrees, especially sodium pyrosulfite is highly toxic and should not be swallowed. It will cause serious damage to the eyes of humans and animals, and it is not conducive to the production and operation of workshop personnel.
The polymuscular cell product prepared by the above-mentioned prior art has the risk of side effects and environmental pollution when it is injected into animals, dipped in a dip, or mixed with bait. If it is used for meat economic animals, it will also involve food safety issues and it is difficult to promote it.

Method used

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  • A kind of veterinary interferon inducer and preparation method thereof
  • A kind of veterinary interferon inducer and preparation method thereof
  • A kind of veterinary interferon inducer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A veterinary interferon inducer, which is made up of the following components: a volume of 500 mL of sodium chloride-phosphate buffer with a pH of 7.2, and a volume of 1 mL of a calcium chloride aqueous solution with a concentration of 44.4 g / L , The volume is 499 mL of chitosan hydrochloride aqueous solution with a concentration of 0.65 g / L, 0.5 g of polyinosinic acid, and 0.5 g of polycytidylic acid.

[0027] The preparation method of the interferon inducer for animals includes the following steps:

[0028] a. Take 0.5g of polyinosinic acid, then dissolve it with 250mL of sodium chloride-phosphate buffer, and then heat it at 45°C for 5 minutes;

[0029] b. Take 0.5g of polycytidylic acid, then dissolve it with 250mL of sodium chloride-phosphate buffer, and then heat it at 45°C for 5 minutes;

[0030] c. Mix the liquid obtained in step a and step b, and then stir at a speed of 30 rpm for 3 minutes; then react at a temperature of 45° C. for 30 minutes, and keep stirring at a sp...

Embodiment 2

[0056] A veterinary interferon inducer, which is made of the following components: sodium chloride-phosphate buffer with a pH of 7.2, a calcium chloride aqueous solution with a concentration of 10 g / L, and a shell with a concentration of 0.1 g / L Polysaccharide hydrochloride aqueous solution, polyinosinic acid, polycytidylic acid, the volume ratio of the polyinosinic acid mass to the sodium chloride-phosphate buffer is 0.5 g / L, and the polycytidylic acid mass The volume ratio of sodium chloride-phosphate buffer is 0.5g / L, the volume ratio of the calcium chloride aqueous solution to the sodium chloride-phosphate buffer is 16:1000, and the chitosan hydrochloride aqueous solution is The volume ratio of sodium chloride-phosphate buffer is 984:1000; the total volume of the calcium chloride aqueous solution and the chitosan hydrochloride aqueous solution and the volume ratio of sodium chloride-phosphate buffer is 1:1.

[0057] The preparation method of the interferon inducer for animals...

Embodiment 3

[0086] A veterinary interferon inducer, which is made of the following components: sodium chloride-phosphate buffer with a pH of 7.2, an aqueous calcium chloride solution with a concentration of 80 g / L, and chitosan with a concentration of 5 g / L Sugar hydrochloride aqueous solution, polyinosinic acid, polycytidylic acid, the volume ratio of the polyinosinic acid mass to the sodium chloride-phosphate buffer is 10g / L, the polycytidylic acid mass and the chlorination The volume ratio of sodium-phosphate buffer is 10g / L, the volume ratio of the calcium chloride aqueous solution and the sodium chloride-phosphate buffer is 2:1000, the chitosan hydrochloride aqueous solution and sodium chloride -The volume ratio of the phosphate buffer is 998:1000; the total volume of the calcium chloride aqueous solution and the chitosan hydrochloride aqueous solution to the sodium chloride-phosphate buffer volume ratio is 1:1.

[0087] The preparation method of the interferon inducer for animals in th...

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Abstract

The invention relates to a veterinary interferon inducer. The veterinary interferon inducer is prepared from the following components: a sodium chloride-phosphate buffer solution with the pH value of 7.2, a 10-80g / L calcium chloride aqueous solution, a 0.1-5g / L chitosan hydrochloride solution, polyinosinic acid and polycytidysic acid. The invention further provides a preparation method of the veterinary interferon inducer. The veterinary interferon inducer provided by the invention is few in side reaction, low in irritation and high in safety, and the preparation method can avoid precipitates generated by calcium chloride and other components.

Description

Technical field [0001] The invention relates to an interferon inducer, in particular to an interferon inducer base for animals and a preparation method thereof. Background technique [0002] Interferon (Interferon, IFN), is a kind of cytokine, has many functions such as inhibiting cell division, regulating immunity, anti-virus and anti-tumor. As a broad-spectrum antiviral agent, interferon does not directly kill or inhibit viruses. It mainly uses cell surface receptors to make cells produce antiviral proteins, thereby inhibiting virus replication. It can also enhance natural killer cells (NK cells). ), the vitality of macrophages and T lymphocytes, which play a role in immune regulation and enhance antiviral ability. They have broad-spectrum antiviral activity on the same cells, affecting cell growth, differentiation, and regulating immune function. [0003] Polyinosine, also known as polyinosinic acid-cytidylic acid, is a synthetic double-stranded RNA polymer. It is a strong int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/80A61K47/36A61K33/04A61P31/12A61P31/04A61P35/00A61P33/02A61P39/00A61P37/02
Inventor 陈瑞爱张爱国刘玉鹏赖汉漳
Owner SOUTH CHINA AGRI UNIV
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