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A kind of biological bone cement material and its preparation method

A technology of bone cement and biotype, which is used in the preparation of biotype bone cement materials and the field of biotype bone cement materials, can solve the problems of fast degradation of bone cement, and achieve improved anti-collapse performance, improved mechanical properties, good strength and The effect of degradation rate

Inactive Publication Date: 2017-12-15
毕文志
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a biological bone cement material, which solves the problem of fast degradation of bone cement in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] Step 1, preparation of calcium sulfate hemihydrate phase powder

[0019] Add ethanol to the solution of mixed succinic acid, calcium hydroxide and water in a closed steam pressure cooker under the pressure of 0.2-0.3MPa and 135-145°C, then add sulfuric acid to react, filter and dry the obtained powder is sulfuric acid hemihydrate Calcium phase powder;

[0020] Step 2, weighing, weighing the following components according to mass percentage: polyacrylic acid microspheres 12%-20%, calcium sulfate hemihydrate phase powder 50%-60%, carbon nanotubes 2%-10%, and the balance is to Ionized water, the total amount of the above components is 100%;

[0021] Step 3. Mix the weighed polyacrylic acid microspheres, calcium sulfate hemihydrate phase powder, carbon nanotubes 2, and deionized water for 0.5-1 minute to prepare the bio-bone cement material.

Embodiment 1

[0023] A method for preparing a biological bone cement material, specifically implemented according to the following steps: add ethanol to a solution of mixed succinic acid, calcium hydroxide and water in a steam pressure cooker with a pressure of 0.25 MPa and a temperature of 140°C, and then add sulfuric acid React, filter and dry the obtained powder to be calcium sulfate hemihydrate phase powder; weigh the following components according to mass percentage: polyacrylic acid microspheres 15%, calcium sulfate hemihydrate phase powder 55%, carbon nanotubes 8%, balance It is deionized water, and the total amount of the above components is 100%; the weighed polyacrylic acid microspheres, calcium sulfate hemihydrate phase powder, carbon nanotubes, and deionized water are mixed for 1 minute, and the biological bone cement material is prepared .

[0024] Rat bone marrow mesenchymal stem cells were cultured from the leaching solution of biological bone cement materials. On the third d...

Embodiment 2

[0026] A method for preparing a biological bone cement material, which is specifically implemented according to the following steps: add ethanol to a solution of mixed succinic acid, calcium hydroxide and water in a closed steam pressure cooker under the pressure of 0.2 MPa and 145°C, and then add sulfuric acid React, filter and dry the obtained powder to be calcium sulfate hemihydrate phase powder; weigh the following components according to mass percentage: polyacrylic acid microspheres 12%, calcium sulfate hemihydrate phase powder 60%, carbon nanotubes 2%, balance It is deionized water, and the total amount of the above components is 100%; the weighed polyacrylic acid microspheres, calcium sulfate hemihydrate phase powder, carbon nanotubes, and deionized water are mixed for 0.5 minutes, and the bio-type bone cement material is prepared .

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Abstract

The invention discloses a biological bone cement material, which is composed of the following components according to the mass percentage: polyacrylic acid microspheres 12%-20%, calcium sulfate hemihydrate phase powder 50%-60%, carbon nanotubes 2%-10% %, the balance is deionized water, and the total amount of the above components is 100%. The invention also discloses a preparation method of a biological bone cement material. The biological bone cement material is a new type of injectable artificial bone with good strength, degradation speed, osteoconduction and osteoinduction, and can be completely replaced by the host bone in the end. complete bone reconstruction.

Description

technical field [0001] The invention belongs to the technical field of medical biological materials, and in particular relates to a biological bone cement material, and also relates to a preparation method of the biological bone cement material. Background technique [0002] Osteoporotic vertebral compression fractures (Osteoporotic Vertebral Compression Fractures, OVCFs) are very common and will become more severe as the average age of the population increases. Vertebral compression fractures not only have a high incidence rate, but also have serious consequences. Traditional treatment includes bed rest and brace treatment. With the development of medical imaging technology and the development of minimally invasive spinal surgery, we found that the occurrence of osteonecrosis after osteoporotic vertebral fractures has gradually increased, which is ineffective for traditional treatment methods including: pain relief, immobilization, and bed rest. Osteonecrosis after osteopo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/50
Inventor 毕文志
Owner 毕文志