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2-phenyl-5-heterocyclyl-tetrahydro-2h-pyran-3-amine compounds for use in the treatment of diabetes and its associated disorders

A technology of compound and heterocycloalkyl, which is applied in the field of preparing the compound and the pharmaceutical composition containing them, can solve problems such as exacerbating the risk of cardiovascular disease and insulin resistance, and achieve prolongation of the pharmacokinetic distribution curve, long-term Half-life, effect of prolonging the dosing interval

Inactive Publication Date: 2015-06-24
CADILA HEALTHCARE LTD
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

With the exception of incretin therapy, most of the available antihyperglycemic agents including insulin promote weight gain, which further exacerbates obesity-related cardiovascular disease risk and insulin resistance (Diabetes Care, 27, 1535-1540, 2004 ; Ann. Intern. Med., -147, 386-399, 2007)

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  • 2-phenyl-5-heterocyclyl-tetrahydro-2h-pyran-3-amine compounds for use in the treatment of diabetes and its associated disorders
  • 2-phenyl-5-heterocyclyl-tetrahydro-2h-pyran-3-amine compounds for use in the treatment of diabetes and its associated disorders
  • 2-phenyl-5-heterocyclyl-tetrahydro-2h-pyran-3-amine compounds for use in the treatment of diabetes and its associated disorders

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Embodiment Construction

[0019] One embodiment of the present invention provides novel compounds of general formula (I), their tautomeric forms, their enantiomers, their diastereomers, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutical compositions comprising them or suitable mixtures thereof.

[0020] In a further embodiment of the present invention is provided a pharmaceutical composition containing compounds of general formula (I), their tautomeric forms, their enantiomers, their diastereoisomers, their stereoisomers isomers, their pharmaceutically acceptable salts, or their mixtures in combination with suitable carriers, solvents, diluents, etc., which are usually used for the preparation of such compositions.

[0021] In a further embodiment, the novel compounds of the present invention are provided as DPP-IV inhibitors, which are used in mammals by administering therapeutically effective and non-toxic amounts of compounds of general formula (I) or their pharmaceutica...

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Abstract

The present invention relates to novel compounds of the general formula (I) their tautomeric forms, their enantiomers, their diastereoisomers, their pharmaceutically accepted salts, or pro-drugs thereof, which are useful for the treatment or prevention of diabetes mellitus (DM), obesity and other metabolic disorders. The invention also relates to process for the manufacture of said compounds, and pharmaceutical compositions containing them and their use.

Description

technical field [0001] The present invention relates to novel compounds of general formula (I), their tautomeric forms, their enantiomers, their diastereoisomers, their pharmaceutically acceptable salts or their prodrugs, which can be used in Treatment or prevention of diabetes and related disorders, obesity and other metabolic disorders. The invention also relates to processes for the preparation of said compounds and pharmaceutical compositions comprising them and their use. Background technique [0002] Metabolic syndrome (or Syndrome X) is a collection of related disorders influenced by lifestyle, genetic predisposition and environment (Lancet, 365, 1415, 2005; Diabetes, 41, 715, 1992). Obesity and diabetes have emerged as global epidemics in the 21st century and have become major global health problems (Diabetic Medicine, 14, S7-S85, 1997; Nature Med., 12, 62-66, 2006; Diabetes Care, 27, 1047 -1053, 2004). Diabetes mellitus (DM) refers to a disease derived from multi...

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Application Information

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IPC IPC(8): C07D405/04C07D471/04C07D487/04C07D487/10C07D491/04C07D495/04A61K31/351A61K31/407A61P3/00
CPCC07D405/04C07D471/04C07D487/04C07D487/10C07D491/04C07D495/04A61K31/403A61K31/407A61K31/435A61K31/437C07D471/10C07D491/048A61P3/00A61P3/04A61P43/00A61P3/10A61K45/06
Inventor 兰吉特·C·德赛拉杰什·巴赫卡尔普拉迪普·亚达夫阿米特吉里·戈斯瓦密潘卡杰·帕特尔
Owner CADILA HEALTHCARE LTD
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